Search Results - "Grottke, Astrid"

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells by Holler, Marina, Grottke, Astrid, Mueck, Katharina, Manes, Julia, Jücker, Manfred, Rodemann, H Peter, Toulany, Mahmoud

“…Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Akt activity mediates the repair of ionizing…”
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Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4 by Grottke, Astrid, Ewald, Florian, Lange, Tobias, Nörz, Dominik, Herzberger, Christiane, Bach, Johanna, Grabinski, Nicole, Gräser, Lareen, Höppner, Frank, Nashan, Björn, Schumacher, Udo, Jücker, Manfred

“…Treatment of breast cancer patients with distant metastases represents one of the biggest challenges in today's gynecological oncology. Therefore, a better…”
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Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma by Ewald, Florian, Grabinski, Nicole, Grottke, Astrid, Windhorst, Sabine, Nörz, Dominik, Carstensen, Lisa, Staufer, Katharina, Hofmann, Bianca T., Diehl, Frank, David, Kerstin, Schumacher, Udo, Nashan, Björn, Jücker, Manfred

“…Cholangiocarcinoma (CCA) is a rare, but devastating disease arising from the epithelium of intrahepatic and extrahepatic bile ducts. There are neither…”
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Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors by Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Hofmann, Bianca T., Nashan, Björn, Jücker, Manfred

“…Summary Until today, there is no systemic treatment available for advanced cholangiocarcinoma (CCA). Recent studies have shown a frequent upregulation of the…”
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Cerebral metastasis in recurrent squamous cell carcinoma of the vulva: case report and review of the literature by Jaeger, Anna, Biermann, Maxine, Prieske, Katharina, Grimm, Donata, Grottke, Astrid, Salamon, Johannes, Petersen, Cordula, Mueller, Volkmar, Schmalfeldt, Barbara, Woelber, Linn

“…Background Distant metastases from squamous cell cancer of the vulva (VSCC) are encountered rarely and are associated with a poor prognosis. Cerebral…”
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Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis by Kempska, Joanna, Oliveira-Ferrer, Leticia, Grottke, Astrid, Qi, Minyue, Alawi, Malik, Meyer, Felix, Borgmann, Kerstin, Hamester, Fabienne, Eylmann, Kathrin, Rossberg, Maila, Smit, Daniel J, Jücker, Manfred, Laakmann, Elena, Witzel, Isabell, Schmalfeldt, Barbara, Müller, Volkmar, Legler, Karen

“…The PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation,…”
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PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression by Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Horn, Stefan, Lamszus, Katrin, Bartkowiak, Kai, Witzel, Isabell, Westphal, Manfred, Matschke, Jakob, Glatzel, Markus, Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus, Wikman, Harriet

“…Despite improvement of therapeutic treatments for breast cancer, the development of brain metastases has become a major limitation to life expectancy for many…”
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Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma by Ewald, Florian, Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T, Nashan, Björn, Jücker, Manfred

“…Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor…”
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Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL) by Ehm, Patrick, Grottke, Astrid, Bettin, Bettina, Jücker, Manfred

“…Acute lymphoblastic leukemia is the most common cause of cancer-related death in children and, especially for patients in a high-risk group, still represents a…”
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ErbB2 signaling activates the Hedgehog pathway via PI3K–Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts by Kebenko, Maxim, Drenckhan, Astrid, Gros, Stephanie J., Jücker, Manfred, Grabinski, Nicole, Ewald, Florian, Grottke, Astrid, Schultze, Alexander, Izbicki, Jakob R., Bokemeyer, Carsten, Wellbrock, Jasmin, Fiedler, Walter

“…The Hedgehog pathway plays an important role in the pathogenesis of several tumor types, including esophageal cancer. In our study, we show an expression of…”
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Inhibition of AKT3 to increase migration and metastasis by upregulation of S100A4 protein expression by Ewald, Florian, Grottke, Astrid, Lange, Tobias, Schumacher, Udo, Nashan, Bjoern, Juecker, Manfred

“…Abstract only…”
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Abstract 1571: PTEN is an important mediator of tumor and glia cell crosstalk in breast cancer brain metastasis by Wikman, Harriet, Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Matschke, Jakob, Glatzel, Markus, Horn, Stefan, Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus

“…Abstract With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to…”
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Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells by Toulany, Mahmoud, Maier, Julia, Iida, Mari, Rebholz, Simone, Holler, Marina, Grottke, Astrid, Jüker, Manfred, Wheeler, Deric L, Rothbauer, Ulrich, Rodemann, H Peter

“…Akt1 through the C-terminal domain interacts with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and stimulates the repair of DNA double-strand…”
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Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion by Nörz, Dominik, Grottke, Astrid, Bach, Johanna, Herzberger, Christiane, Hofmann, Bianca T., Nashan, Bjorn, Jücker, Manfred, Ewald, Florian

“…Development of small molecular inhibitors against BRAF and MEK has been a breakthrough in the treatment of malignant melanoma. However, the long-term effect is…”
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