Search Results - "Grothe, Michel J."

Spatial patterns of atrophy, hypometabolism, and amyloid deposition in Alzheimer's disease correspond to dissociable functional brain networks by Grothe, Michel J., Teipel, Stefan J.

“…Recent neuroimaging studies of Alzheimer's disease (AD) have emphasized topographical similarities between AD‐related brain changes and a prominent cortical…”
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MRI-based basal forebrain atrophy and volumetric signatures associated with limbic TDP-43 compared to Alzheimer's disease pathology by Teipel, Stefan, Grothe, Michel J.

“…It is not clear to which degree limbic TDP-43 pathology associates with a cholinergic deficit in the absence of Alzheimer's disease (AD) pathology. Replicate…”
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Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum by Moscoso, Alexis, Grothe, Michel J, Ashton, Nicholas J, Karikari, Thomas K, Rodriguez, Juan Lantero, Snellman, Anniina, Suárez-Calvet, Marc, Zetterberg, Henrik, Blennow, Kaj, Schöll, Michael

“…Tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently been proposed as an accessible, scalable, and highly specific biomarker…”
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In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease by Ray, Nicola J, Bradburn, Steven, Murgatroyd, Christopher, Toseeb, Umar, Mir, Pablo, Kountouriotis, George K, Teipel, Stefan J, Grothe, Michel J

“…See Gratwicke and Foltynie (doi:10.1093/brain/awx333) for a scientific commentary on this article. Cognitive impairments in Parkinson's disease show variable…”
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A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems by Vogel, Jacob W., La Joie, Renaud, Grothe, Michel J., Diaz-Papkovich, Alexandr, Doyle, Andrew, Vachon-Presseau, Etienne, Lepage, Claude, Vos de Wael, Reinder, Thomas, Rhalena A., Iturria-Medina, Yasser, Bernhardt, Boris, Rabinovici, Gil D., Evans, Alan C.

“…The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse…”
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Neurogenetic contributions to amyloid beta and tau spreading in the human cortex by Sepulcre, Jorge, Grothe, Michel J., d’Oleire Uquillas, Federico, Ortiz-Terán, Laura, Diez, Ibai, Yang, Hyun-Sik, Jacobs, Heidi I. L., Hanseeuw, Bernard J., Li, Quanzheng, El-Fakhri, Georges, Sperling, Reisa A., Johnson, Keith A.

“…Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease. Unraveling the genetic background for the regional vulnerability…”
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Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment by Grothe, Michel J, Heinsen, Helmut, Amaro, Jr, Edson, Grinberg, Lea T, Teipel, Stefan J

“…Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline, and this effect is believed to be mediated by neuronal…”
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Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection by Teipel, Stefan, Dr, Drzezga, Alexander, MD, Grothe, Michel J, PhD, Barthel, Henryk, MD, Chételat, Gaël, PhD, Schuff, Norbert, PhD, Skudlarski, Pawel, PhD, Cavedo, Enrica, MS, Frisoni, Giovanni B, MD, Hoffmann, Wolfgang, MD, Thyrian, Jochen René, PhD, Fox, Chris, MD, Minoshima, Satoshi, MD, Sabri, Osama, MD, Fellgiebel, Andreas, MD

“…Summary Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a…”
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Basal forebrain volume and metabolism in carriers of the Colombian mutation for autosomal dominant Alzheimer’s disease by Teipel, Stefan, Grazia, Alice, Dyrba, Martin, Grothe, Michel J., Pomara, Nunzio

“…We aimed to study atrophy and glucose metabolism of the cholinergic basal forebrain in non-demented mutation carriers for autosomal dominant Alzheimer's…”
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Does posterior cingulate hypometabolism result from disconnection or local pathology across preclinical and clinical stages of Alzheimer’s disease? by Teipel, Stefan, Grothe, Michel J.

“…Purpose Posterior cingulate cortex (PCC) hypometabolism as measured by FDG PET is an indicator of Alzheimer’s disease (AD) in prodromal stages, such as in mild…”
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Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications by Teipel, Stefan, Grothe, Michel J, Zhou, Juan, Sepulcre, Jorge, Dyrba, Martin, Sorg, Christian, Babiloni, Claudio

“…The objective was to review the literature on diffusion tensor imaging as well as resting-state functional magnetic resonance imaging and…”
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Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease by Pereira, Joana B., Hall, Sara, Jalakas, Mattis, Grothe, Michel J., Strandberg, Olof, Stomrud, Erik, Westman, Eric, van Westen, Danielle, Hansson, Oskar

“…Cholinergic dysfunction plays a prominent role in cognitive impairment in Parkinson's disease (PD). The aim of this study was to assess the relationship of…”
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Cholinergic white matter pathways make a stronger contribution to attention and memory in normal aging than cerebrovascular health and nucleus basalis of Meynert by Nemy, Milan, Cedres, Nira, Grothe, Michel J., Muehlboeck, J-Sebastian, Lindberg, Olof, Nedelska, Zuzana, Stepankova, Olga, Vyslouzilova, Lenka, Eriksdotter, Maria, Barroso, José, Teipel, Stefan, Westman, Eric, Ferreira, Daniel

“…The integrity of the cholinergic system plays a central role in cognitive decline both in normal aging and neurological disorders including Alzheimer’s disease…”
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The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles by Fritz, Hans‐Christian J., Ray, Nicola, Dyrba, Martin, Sorg, Christian, Teipel, Stefan, Grothe, Michel J.

“…The cholinergic basal forebrain (CBF), comprising different groups of cortically projecting cholinergic neurons, plays a crucial role in higher cognitive…”
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Reduced [18F]flortaucipir retention in white matter hyperintensities compared to normal-appearing white matter by Moscoso, Alexis, Grothe, Michel J., Schöll, Michael

“…Purpose Recent research has suggested the use of white matter (WM) reference regions for longitudinal tau-PET imaging. However, tau tracers display affinity…”
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Differential diagnosis of amnestic dementia patients based on an FDG‐PET signature of autopsy‐confirmed LATE‐NC by Grothe, Michel J., Moscoso, Alexis, Silva‐Rodríguez, Jesús, Lange, Catharina, Nho, Kwangsik, Saykin, Andrew J., Nelson, Peter T., Schöll, Michael, Buchert, Ralph, Teipel, Stefan

“…Introduction Limbic age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) is common in advanced age and can underlie a clinical presentation…”
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Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex by Sepulcre, Jorge, Grothe, Michel J, Sabuncu, Mert, Chhatwal, Jasmeer, Schultz, Aaron P, Hanseeuw, Bernard, El Fakhri, Georges, Sperling, Reisa, Johnson, Keith A

“…Abnormal accumulation of tau and amyloid-β (Aβ) proteins in the human brain are 2 pathologic hallmarks of Alzheimer disease (AD). Because pathologic processes…”
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The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment by Peter, Jessica, Mayer, Isabella, Kammer, Thomas, Minkova, Lora, Lahr, Jacob, Klöppel, Stefan, Grothe, Michel J., Orth, Michael

“…We assessed the structure–function relationship of the human cholinergic system and hypothesized that structural measures are associated with short-latency…”
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Partial volume correction in longitudinal tau PET studies: is it really needed? by Costoya-Sánchez, Alejandro, Moscoso, Alexis, Sobrino, Tomás, Ruibal, Álvaro, Grothe, Michel J., Schöll, Michael, Silva-Rodríguez, Jesús, Aguiar, Pablo

“…•The white matter and CSF are the main contributors to PVE in longitudinal tau PET quantification for all cortical regions. All other off-target regions showed…”
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Increased basal forebrain volumes could prevent cognitive decline in LRRK2 Parkinson's disease by Batzu, Lucia, Urso, Daniele, Grothe, Michel J., Veréb, Dániel, Chaudhuri, K. Ray, Pereira, Joana B.

“…It has been recently suggested that LRRK2 mutations are associated with a more benign clinical phenotype and a potentially more preserved cholinergic function…”
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