Search Results - "Groth, Casper"

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects by Groth, Casper, Fortini, Mark E.

“…► Dysregulated Notch signaling is associated with a wide variety of different human cancers. ► γ-Secretase inhibitors block proteolytic activation of Notch and…”
Get full text

Genome-Wide Screen for Context-Dependent Tumor Suppressors Identified Using in Vivo Models for Neoplasia in Drosophila by Groth, Casper, Vaid, Pooja, Khatpe, Aditi, Prashali, Nelchi, Ahiya, Avantika, Andrejeva, Diana, Chakladar, Madhumita, Nagarkar, Sanket, Paul, Rachel, Kelkar, Devaki, Eichenlaub, Teresa, Herranz, Hector, Sridhar, T S, Cohen, Stephen M, Shashidhara, L S

“…Genetic approaches in have successfully identified many genes involved in regulation of growth control as well as genetic interactions relevant to the…”
Get full text

New hybrids between Saccharomyces sensu stricto yeast species found among wine and cider production strains by Masneuf, I. (University of Denmark, Lyngby, Denmark.), Hansen, J, Groth, C, Piskur, J, Dubourdieu, D

“…Two yeast isolates, a wine-making yeast first identified as a Mel+ strain (ex. S. uvarum) and a cider-making yeast, were characterized for their nuclear and…”
Get full text

A natural chimeric yeast containing genetic material from three species by Groth, C, Hansen, J, Piskur, J

“…The Saccharomyces sp. CID1 isolate (CBS 8614) and several other Saccharomyces sensu stricto yeasts were analysed for their mitochondrial and nuclear genes. The…”
Get full text

Diversity in organization and the origin of gene orders in the mitochondrial DNA molecules of the genus Saccharomyces by Groth, C, Petersen, R F, Piskur, J

“…Sequencing of the Saccharomyces cerevisiae nuclear and mitochondrial genomes provided a new background for studies on the evolution of the genomes. In this…”
Get full text

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup by Groth, Casper, Sasamura, Takeshi, Khanna, Mansi R, Whitley, Michael, Fortini, Mark E

“…Developmental patterning requires the precise interplay of numerous intercellular signaling pathways to ensure that cells are properly specified during tissue…”
Get full text

Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation by Li, Song, Wang, Hongyan, Groth, Casper

“…Drosophila larval brain stem cells (neuroblasts) have emerged as an important model for the study of stem cell asymmetric division and the mechanisms…”
Get full text

Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP by Groth, Casper, Alvord, W Gregory, Quiñones, Octavio A, Fortini, Mark E

“…The gamma-secretase aspartyl protease is responsible for the cleavage of numerous type I integral membrane proteins, including amyloid precursor protein (APP)…”
Get more information

The structure and function of vertebrate fibroblast growth factor receptor 1 by Groth, Casper, Lardelli, Michael

“…The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed…”
Get full text

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos by Nornes, Svanhild, Groth, Casper, Camp, Esther, Ey, Peter, Lardelli, Michael

“…Dominant mutations in presenilin1 (PS1) and presenilin2 (PS2) are a major cause of early-onset Alzheimer’s disease. In this report we analyze the expression of…”
Get full text

Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary by Scholpp, Steffen, Groth, Casper, Lohs, Claudia, Lardelli, Michael, Brand, Michael

“…FGFR1 is an important signalling molecule during embryogenesis and in adulthood. FGFR1 mutations in human may lead to developmental defects and pathological…”
Get full text

Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2 by Groth, Casper, Nornes, Svanhild, McCarty, Rosa, Tamme, Richard, Lardelli, Michael

“…Presenilins play prominent roles in the molecular pathogenesis of Alzheimer's disease and during embryo development. We have isolated a zebrafish presenilin…”
Get full text

High-rate evolution of Saccharomyces sensu lato chromosomes by Špı́rek, Mário, Yang, Jun, Groth, Casper, Petersen, Randi F, Langkjær, Rikke B, Naumova, Elena S, Sulo, Pavol, Naumov, Gennadi I, Piškur, Jure

“…Forty isolates belonging to the Saccharomyces sensu lato complex were analyzed for one nuclear and two mitochondrial sequences, and for their karyotypes. These…”
Get full text

Structure and genetic stability of mitochondrial genomes vary among yeasts of the genus Saccharomyces by Piskur, J, Smole, S, Groth, C, Petersen, R F, Pedersen, M B

“…Several yeast species/isolates belonging to the genus Saccharomyces were examined for the organization of their mtDNAs and ability to generate petite mutants…”
Get more information