Search Results - "Grotendorst, Gary R"

Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation by Grotendorst, Gary R, Duncan, Matthew R

“…All members of the Ctgf, Cyr61, and Nov (CCN) family share a high degree of sequence homology and conservation of structural motifs and domains. Here, we…”
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Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation by Grotendorst, Gary R., Rahmanie, Hamed, Duncan, Matthew R.

“…Fibroblast proliferation, differentiation into myofibroblasts, and increased collagen synthesis are key events during both normal wound repair and fibrotic…”
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Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells by Guney, Michelle A, Petersen, Christine P, Boustani, Andre, Duncan, Matthew R, Gunasekaran, Uma, Menon, Renuka, Warfield, Courtney, Grotendorst, Gary R, Means, Anna L, Economides, Aris N, Gannon, Maureen

“…Type 1 and type 2 diabetes result from an absolute or relative reduction in functional β-cell mass. One approach to replacing lost β-cell mass is…”
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A connective tissue growth factor signaling receptor in corneal fibroblasts by Blalock, Timothy D, Gibson, Daniel J, Duncan, Matthew R, Tuli, Sonal S, Grotendorst, Gary R, Schultz, Gregory S

“…To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). Radiolabeled recombinant human CTGF…”
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Effect of connective tissue growth factor on protein kinase expression and activity in human corneal fibroblasts by Radhakrishnan, Siva S, Blalock, Timothy D, Robinson, Paulette M, Secker, Genevieve, Daniels, Julie, Grotendorst, Gary R, Schultz, Gregory S

“…To investigate signal transduction pathways for connective tissue growth factor (CTGF) in human corneal fibroblasts (HCF). Expression of 75 kinases in cultures…”
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Involvement of CTGF in TGF-β1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress by GARRETT, Qian, KHAW, Peng T, BLALOCK, Timothy D, SCHULTZ, Gregory S, GROTENDORST, Gary R, DANIELS, Julie T

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Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury by Benson, Janet M., Seagrave, JeanClare, Weber, Waylon M., Santistevan, Colleen D., Grotendorst, Gary R., Schultz, Gregory S., March, Thomas H.

“…ABSTRACT The objective of these studies was to provide detailed analyses of the time course of sulfur mustard (SM) vapor‐induced clinical, histological, and…”
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Expression of Connective Tissue Growth Factor after Glaucoma Filtration Surgery in a Rabbit Model by Esson, Douglas W, Neelakantan, Arvind, Iyer, Sandhya A, Blalock, Timothy D, Balasubramanian, Lakshmi, Grotendorst, Gary R, Schultz, Gregory S, Sherwood, Mark B

“…Connective tissue growth factor (CTGF) appears to play a significant role in mediating fibrosis in several tissues. To gain further understanding of the role…”
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Connective Tissue Growth Factor Expression and Action in Human Corneal Fibroblast Cultures and Rat Corneas after Photorefractive Keratectomy by Blalock, Timothy D, Duncan, Matthew R, Varela, Juan C, Goldstein, Michael H, Tuli, Sonal S, Grotendorst, Gary R, Schultz, Gregory S

“…Connective tissue growth factor (CTGF) has been linked to fibrosis in several tissues. In this study, the interactions between CTGF and transforming growth…”
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Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: Possible role of Th17 cells in chronic lung pathology by Mishra, Neerad C., Rir-sima-ah, Jules, Grotendorst, Gary R., Langley, Raymond J., Singh, Shashi P., Gundavarapu, Sravanthi, Weber, Waylon M., Pena-Philippides, Juan C., Duncan, Matthew R., Sopori, Mohan L.

“…Sulfur mustard (SM) is a highly toxic chemical warfare agent that remains a threat to human health. The immediate symptoms of pulmonary distress may develop…”
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Sulfur mustard vapor effects on differentiated human lung cells by Seagrave, JeanClare, Weber, Waylon M., Grotendorst, Gary R.

“…Context: sulfur mustard (SM) causes skin blistering and long-term pulmonary dysfunction. Its adverse effects have been studied in battlefield-exposed humans,…”
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Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor by Frazier, Ken, Williams, Shawn, Kothapalli, Devashish, Klapper, Helene, Grotendorst, Gary R.

“…Connective tissue growth factor (CTGF) is a 36- to 38-kDa peptide that is selectively induced by transforming growth factor-β (TGF-β) in fibroblastic cell…”
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Mediation of transforming growth Factor-β1-Stimulated matrix contraction by fibroblasts: A role for connective tissue growth factor in contractile scarring by DANIELS, Julie T, SCHULTZ, Gregory S, BLALOCK, Timothy D, GARRETT, Qian, GROTENDORST, Gary R, DEAN, Nicholas M, KHAW, Peng T

“…Excessive cell-mediated tissue contraction after injury can lead to morbid contractile scarring in the body. In the eye this can cause blindness because of…”
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Expression of connective tissue growth factor in intra-abdominal adhesions by Thaler, Klaus, Mack, Judith A, Zhao, Rong Hua, Berho, Mariana, Grotendorst, Gary R, Duncan, Matthew R, Williams, Shawn, Miranda, Julianne R, Wexner, Steven D, Abramson, Susan R

“…Connective tissue growth factor stimulates fibroblast proliferation and extracellular matrix deposition in many fibrotic disorders. The aim of our study was to…”
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Uptake, Tissue Distribution, and Excretion of 14C-Sulfur Mustard Vapor Following Inhalation in F344 Rats and Cutaneous Exposure in Hairless Guinea Pigs by Benson, Janet M., Tibbetts, Brad M., Weber, Waylon M., Grotendorst, Gary R.

“…Sulfur mustard (SM), a vessicating agent, has been used in chemical warfare since 1918. The purpose of this study was to quantitate SM vapor deposition, tissue…”
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Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders by Igarashi, Atsuyuki, Nashiro, Kiyoko, Kikuchi, Kanako, Sato, Shinichi, Ihn, Hironobu, Fujimoto, Manabu, Grotendorst, Gary R., Takehara, Kazuhiko

“…Connective tissue growth factor (CTGF) is a novel peptide that exhibits platelet-derived growth factor-like activities and is produced by skin fibroblasts…”
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Cellular transformation by coordinated action of three peptide growth factors from human platelets by Assoian, Richard K, Grotendorst, Gary R, Miller, Dorothea M, Sporn, Michael B

“…Platelet-derived growth factor (PDGF) is known to be involved in regulating the mitosis of connective tissue cells, and recent studies have also shown that it…”
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Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease? by Dammeier, Johanna, Brauchle, Maria, Falk, Werner, Grotendorst, Gary R, Werner, Sabine

“…Inflammatory bowel disease (IBD) is a multifactorial disorder which is characterized by massive damage of the epithelium and the underlying mesenchyme of the…”
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Activated human monocytes express the c- sis proto-oncogene and release a mediator showing PDGF-like activity by Martin, George R, Bitterman, Peter B, Mornex, Jean-Francois, Crystal, Ronald G, Martinet, Yves, Grotendorst, Gary R

“…Current ideas about the mechanism of wound healing and the pathogenesis of atherosclerosis, pulmonary fibrosis and hepatic fibrosis suggest a central role for…”
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CCN Proteins Are Distinct from and Should Not Be Considered Members of the Insulin-Like Growth Factor-Binding Protein Superfamily by Grotendorst, Gary R, Lau, Lester F, Perbal, Bernard

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