Search Results - "Grote, Deanna M."

Soluble and membrane-bound TGF-β-mediated regulation of intratumoral T cell differentiation and function in B-cell non-Hodgkin lymphoma by Yang, Zhi-Zhang, Grote, Deanna M, Ziesmer, Steven C, Xiu, Bing, Yates, Nicole R, Secreto, Frank J, Hodge, Lucy S, Witzig, Thomas E, Novak, Anne J, Ansell, Stephen M

“…While the effect of TGF-β on malignant B cells in non-Hodgkin lymphoma (NHL) has been previously evaluated, studies to specifically define the role of TGF-β in…”
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Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity by Elsawa, Sherine F., Novak, Anne J., Ziesmer, Steven C., Almada, Luciana L., Hodge, Lucy S., Grote, Deanna M., Witzig, Thomas E., Fernandez-Zapico, Martin E., Ansell, Stephen M.

“…Although proinflammatory and chemotactic cytokines can profoundly affect the tumor microenvironment, and many of them have been shown to have therapeutic…”
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Establishment and characterization of a novel Waldenström macroglobulinemia cell line, MWCL-1 by Hodge, Lucy S., Novak, Anne J., Grote, Deanna M., Braggio, Esteban, Ketterling, Rhett P., Manske, Michelle K., Price Troska, Tammy L., Ziesmer, Steven C., Fonseca, Rafael, Witzig, Thomas E., Morice, William G., Gertz, Morie A., Ansell, Stephen M.

“…Waldenström macroglobulinemia (WM) is a rare, lymphoplasmacytic lymphoma characterized by hypersecretion of immunoglobulin M (IgM) protein and tumor…”
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IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma by Yang, Zhi-Zhang, Grote, Deanna M, Ziesmer, Steven C, Niki, Toshiro, Hirashima, Mitsuomi, Novak, Anne J, Witzig, Thomas E, Ansell, Stephen M

“…The cytokine IL-12 induces IFN-γ production by T and NK cells. In preclinical models, it contributes to antitumor immunity. However, in clinical testing, it…”
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Elevated Serum B-Lymphocyte Stimulator Levels in Patients With Familial Lymphoproliferative Disorders by NOVAK, Anne J, GROTE, Deanna M, JELINEK, Diane F, CERHAN, James R, GROSS, Jane A, HARDER, Brandon, DILLON, Stacey R, ANSELL, Stephen M, ZIESMER, Steven C, KLINE, Michael P, MANSKE, Michelle K, SLAGER, Susan, WITZIG, Thomas E, SHANAFELT, Tail, CALL, Timothy G, KAY, Neil E

“…Serum B-lymphocyte stimulator (BLyS) levels have been found to be elevated in a number of immune disease models. Therefore, we sought to establish whether BLyS…”
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Pattern of CD14+ Follicular Dendritic Cells and PD1+ T Cells Independently Predicts Time to Transformation in Follicular Lymphoma by SMELTZER, Jacob P, JONES, Jason M, NOVAK, Anne J, ANSELL, Stephen M, ZIESMER, Steven C, GROTE, Deanna M, BING XIU, RISTOW, Kay M, ZHI ZHANG YANG, NOWAKOWSKI, Grzegorz S, FELDMAN, Andrew L, CERHAN, James R

“…Transformation of follicular lymphoma is a critical event associated with a poor prognosis. The role of the tumor microenvironment in previous transformation…”
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Soluble IL-2Rα facilitates IL-2–mediated immune responses and predicts reduced survival in follicular B-cell non-Hodgkin lymphoma by Yang, Zhi-Zhang, Grote, Deanna M., Ziesmer, Steven C., Manske, Michelle K., Witzig, Thomas E., Novak, Anne J., Ansell, Stephen M.

“…Elevated serum levels of the soluble form of IL-2 receptor α (sIL-2Rα) have been correlated with a poor prognosis in a variety of different types of cancers…”
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The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma by Boddicker, Rebecca L., Kip, N. Sertac, Xing, Xiaoming, Zeng, Yu, Yang, Zhi-Zhang, Lee, Jeong-Heon, Almada, Luciana L., Elsawa, Sherine F., Knudson, Ryan A., Law, Mark E., Ketterling, Rhett P., Cunningham, Julie M., Wu, Yanhong, Maurer, Matthew J., O'Byrne, Megan M., Cerhan, James R., Slager, Susan L., Link, Brian K., Porcher, Julie C., Grote, Deanna M., Jelinek, Diane F., Dogan, Ahmet, Ansell, Stephen M., Fernandez-Zapico, Martin E., Feldman, Andrew L.

“…Peripheral T-cell lymphomas (PTCLs) are generally aggressive non-Hodgkin lymphomas with poor overall survival rates following standard therapy. One-third of…”
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Development of a Human Monoclonal Antibody for Potential Therapy of CD27-Expressing Lymphoma and Leukemia by VITALE, Laura A, HE, Li-Zhen, ANSELL, Stephen M, MARSH, Henry, KELER, Tibor, THOMAS, Lawrence J, WIDGET, Jennifer, WEIDLICK, Jeffrey, CROCKER, Andrea, O'NEILL, Thomas, STOREY, James, GLENNIE, Martin J, GROTE, Deanna M

“…The TNF receptor superfamily member CD27 is best known for its important role in T-cell immunity but is also recognized as a cell-surface marker on a number of…”
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Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome by Novak, Anne J., Grote, Deanna M., Stenson, Mary, Ziesmer, Steven C., Witzig, Thomas E., Habermann, Thomas M., Harder, Brandon, Ristow, Kay M., Bram, Richard J., Jelinek, Diane F., Gross, Jane A., Ansell, Stephen M.

“…BLyS, recently shown to be critical for survival of normal B cells, has been found to be elevated in a number of immune disease models. A role for BLyS in the…”
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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia by Elsawa, Sherine F., Novak, Anne J., Grote, Deanna M., Ziesmer, Steven C., Witzig, Thomas E., Kyle, Robert A., Dillon, Stacey R., Harder, Brandon, Gross, Jane A., Ansell, Stephen M.

“…Waldenström macroglobulinemia (WM) is a serious and frequently fatal B-cell malignancy associated with an elevated monoclonal IgM protein in the serum. Many of…”
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An oncolytic measles virus engineered to enter cells through the CD20 antigen by Bucheit, Amanda D, Kumar, Shaji, Grote, Deanna M, Lin, Yukang, von Messling, Veronika, Cattaneo, Roberto B, Fielding, Adele K

“…We have earlier shown that attenuated measles virus (MV) has therapeutic potential as a replicating oncolytic virus in models of non-Hodgkin's lymphoma (NHL)…”
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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia by Elsawa, Sherine F., Novak, Anne J., Grote, Deanna M., Ziesmer, Steven C., Witzig, Thomas E., Kyle, Robert A., Dillon, Stacey R., Harder, Brandon, Gross, Jane A., Ansell, Stephen M.

“…Waldenström macroglobulinemia (WM) is a serious and frequently fatal B-cell malignancy associated with an elevated monoclonal IgM protein in the serum. Many…”
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TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma by Yang, Z-Z, Grote, D M, Xiu, B, Ziesmer, S C, Price-Troska, T L, Hodge, L S, Yates, D M, Novak, A J, Ansell, S M

“…Transforming growth factor beta (TGF-β) has an important role in mediating T-cell suppression in B-cell non-Hodgkin lymphoma (NHL). However, the underlying…”
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PD-1 Expression Defines Two Distinct T-Cell Subpopulations That Differentially Impact Patient Outcomes In Follicular Lymphoma by Yang, Zhi-Zhang, Grote, Deanna M., Ziesmer, Steven C., Ansell, Stephen M

“…The role of intratumoral PD-1+ T cells and their contribution to patient outcome in follicular lymphoma (FL) has been controversial. While some studies have…”
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Abstract 2323: Interferon regulatory factor-4 is transcriptionally regulated by NF-κB in peripheral T-cell lymphomas by Boddicker, Rebecca L., Kip, N. Sertac, Almada, Luciana L., Porcher, Julie C., Grote, Deanna M., Ansell, Stephen M., Fernandez-Zapico, Martin E., Feldman, Andrew L.

“…Interferon regulatory factor-4 (IRF4) is a tightly-regulated transcription factor involved in growth and differentiation of normal lymphocytes. IRF4 is…”
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Interactions Between PD-1 and PD-L1 and PD-L2 Promote Malignant B-Cell Growth in Waldenstrom Macroglobulinemia by Grote, Deanna M., Ziesmer, Steven C., Hodge, Lucy S., Price-Troska, Tammy L., Novak, Anne J., Yang, Zhi-Zhang, Ansell, Stephen M

“…Programmed death 1 (PD-1) is a T cell co-inhibitory receptor with two ligands, PD-L1 and PD-L2. In B-cell malignancies, this pathway plays a major role in…”
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Soluble and Membrane-Bound TGF-[beta]-Mediated Regulation of Intratumoral T Cell Differentiation and Function in B-Cell Non-Hodgkin Lymphoma by Yang, Zhi-Zhang, Grote, Deanna M, Ziesmer, Steven C, Xiu, Bing, Yates, Nicole R, Secreto, Frank J, Hodge, Lucy S, Witzig, Thomas E, Novak, Anne J, Ansell, Stephen M

“…While the effect of TGF-[beta] on malignant B cells in non-Hodgkin lymphoma (NHL) has been previously evaluated, studies to specifically define the role of…”
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Denileukin diftitox in combination with rituximab for previously untreated follicular B-cell non-Hodgkin's lymphoma by Ansell, S M, Tang, H, Kurtin, P J, Koenig, P A, Nowakowski, G S, Nikcevich, D A, Nelson, G D, Yang, Z, Grote, D M, Ziesmer, S C, Silberstein, P T, Erlichman, C, Witzig, T E

“…Follicular lymphoma exhibits intratumoral infiltration by non-malignant T lymphocytes, including CD4+CD25+ regulatory T (T reg ) cells. We combined denileukin…”
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Monocytes Promote Survival of Malignant T Cells in Cutaneous T-Cell Lymphoma and Are Recruited to the Tumor Microenvironment by CCL5 (RANTES) by Wilcox, Ryan A, David, Wada A, Feldman, Andrew L., Elsawa, Sherine F, Grote, Deanna M, Ziesmer, Steven C, Novak, Anne J, Pittelkow, Mark R., Witzig, Thomas E., Ansell, Stephen M

“…The tumor microenvironment in B-cell non-Hodgkin's lymphoma (NHL) plays an important role in supporting the growth and survival of malignant lymphocytes. In…”
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