Search Results - "Grosveld, G. C"

MN1 overexpression is an important step in the development of inv(16) AML by CARELLA, C, BONTEN, J, GROSVELD, G. C, SIRMA, S, KRANENBURG, T. A, TERRANOVA, S, KLEIN-GELTINK, R, SHURTLEFF, S, DOWNING, J. R, ZWARTHOFF, E. C, LIU, P. P

“…The gene encoding the transcriptional co-activator MN1 is the target of the reciprocal chromosome translocation (12;22)(p13;q12) in some patients with acute…”
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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells by Thierfelder, William E, van Deursen, Jan M, Yamamoto, Koh, Tripp, Ralph A, Sarawar, Sally R, Carson, Richard T, Sangster, Mark Y, Vignali, Dario A. A, Doherty, Peter C, Grosveld, Gerard C, Ihle, James N

“…Signal transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their…”
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The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription by VAN WELY, K. H. M, MEESTER-SMOOR, M. A, JANSSEN, M. J. F. W, AARNOUDSE, A.-J, GROSVELD, G. C, ZWARTHOFF, E. C

“…The translocation t(12;22)(p13;q11) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. MN1 is a transcription coactivator of the retinoic acid…”
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MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice by CARELLA, C, BONTEN, J, REHG, J, GROSVELD, G. C

“…MN1-TEL is the product of the recurrent t(12;22)(p12;q11) associated with human myeloid malignancies. MN1-TEL functions as an activated transcription factor,…”
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SET-induced calcium signaling and MAPK ERK pathway activation mediate dendritic cell-like differentiation of U937 cells by KANDILCI, A, GROSVELD, G. C

“…Human SET, a target of chromosomal translocation in human leukemia encodes a highly conserved, ubiquitously expressed, nuclear phosphoprotein. SET mediates…”
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Defective Lymphoid Development in Mice Lacking Jak3 by Nosaka, Tetsuya, Jan M. A. van Deursen, Tripp, Ralph A., Thierfelder, William E., Witthuhn, Bruce A., McMickle, Anthony P., Doherty, Peter C., Grosveld, Gerard C., Ihle, James N.

“…The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is…”
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The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity by Buijs, Arjan, van Rompaey, Luc, Molijn, Anco C., Davis, J. Nathan, Vertegaal, Alfred C. O., Potter, Mark D., Adams, Constantin, van Baal, Sjozèf, Zwarthoff, Ellen C., Roussel, Martine F., Grosveld, Gerard C.

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype by Sorrentino, Brian P, Zhou, Sheng, Schuetz, John D, Bunting, Kevin D, Colapietro, Anne-Marie, Sampath, Janardhan, Morris, John J, Lagutina, Irina, Grosveld, Gerard C, Osawa, Mitsujiro, Nakauchi, Hiromitsu

“…Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed…”
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12p abnormalities and the TEL gene (ETV6) in childhood acute lymphoblastic leukemia by RAIMONDI, S. C, SHURTLEFF, S. A, DOWNING, J. R, RUBNITZ, J, MATHEW, S, HANCOCK, M, PUI, C.-H, RIVERA, G. K, GROSVELD, G. C, BEHM, F. G

“…Although abnormalities involving the short arm of chromosome 12 (12p) are one of the most frequently observed rearrangements in childhood acute lymphoblastic…”
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FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts by Bois, Philippe R.J., Grosveld, Gerard C.

“…Activation of the transcription factor FKHR (Forkhead in human rhabdomyosarcoma, FOXO1a) in various established cell lines induces cell cycle arrest followed…”
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Detection of the Philadelphia chromosome in interphase nuclei by Arnoldus, E P, Wiegant, J, Noordermeer, I A, Wessels, J W, Beverstock, G C, Grosveld, G C, van der Ploeg, M, Raap, A K

“…Double fluorescence in situ hybridization was used to detect Philadelphia (Ph) chromosomes in interphase nuclei and metaphases of patients with chronic myeloid…”
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Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells by Moriggl, Richard, Topham, David J, Teglund, Stephan, Sexl, Veronika, McKay, Catriona, Wang, Demin, Hoffmeyer, Angelika, van Deursen, Jan, Sangster, Mark Y, Bunting, Kevin D, Grosveld, Gerard C, Ihle, James N

“…Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice deficient in both genes lack all growth hormone and prolactin functions but retain…”
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Pax3-FKHR Knock-In Mice Show Developmental Aberrations but Do Not Develop Tumors by Lagutina, Irina, Conway, Simon J., Sublett, Jack, Grosveld, Gerard C.

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DNA sequences necessary for transcription of the rabbit β -globin gene in vivo by Grosveld, G. C, de Boer, E, Shewmaker, C. K, Flavell, R. A

“…The DNA sequences required for the expression of the rabbit-beta-globin gene in vivo have been examined. A variety of mutant rabbit beta-globin gene templates…”
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The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription by VAN WELY, Karel H. M, MOLIJN, Anco C, BUIJS, Arjan, MEESTER-SMOOR, Magda A, AARNOUDSE, Albert Jan, HELLEMONS, Anita, DEN BESTEN, Pim, GROSVELD, Gerard C, ZWARTHOFF, Ellen C

“…The t(12;22) creates an MN1-TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the ETS family of transcription…”
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Genetic heterogeneity in tuberous sclerosis by Janssen, L A, Sandkuyl, L A, Merkens, E C, Maat-Kievit, J A, Sampson, J R, Fleury, P, Hennekam, R C, Grosveld, G C, Lindhout, D, Halley, D J

“…Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by widespread hamartosis. Preliminary evidence of linkage between the TSC locus and…”
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Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells by Zhou, X Y, Morreau, H, Rottier, R, Davis, D, Bonten, E, Gillemans, N, Wenger, D, Grosveld, F G, Doherty, P, Suzuki, K, Grosveld, G C, d'Azzo, A

“…The lysosomal storage disorder galactosialidosis results from a primary deficiency of the protective protein/cathepsin A (PPCA), which in turn affects the…”
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A transcription map for the rabbit beta-globin gene by Grosveld, G C, Koster, A, Flavell, R A

“…We have characterized the transcripts of the beta-globin gene in RNA isolated from rabbit bone marrow using the S1 mapping procedure of Berk and Sharp (1977)…”
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The Nucleoporin CAN/Nup214 Binds to both the Cytoplasmic and the Nucleoplasmic Sides of the Nuclear Pore Complex in Overexpressing Cells by Boer, Judith M., van Deursen, Jan M.A., Croes, Huib J., Fransen, Jack A.M., Grosveld, Gerard C.

“…CAN/Nup214, an essential component of the vertebrate nuclear pore complex (NPC), is required for proper cell cycle progression and nucleocytoplasmic transport…”
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Isolation and characterization of the oligo(dA-dT) clusters and their flanking DNA segments in the rabbit genome by Flavell, R A, Van den Berg, F M, Grosveld, G C

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