Search Results - "Grosveld, G."

Forces driving the three‐dimensional folding of eukaryotic genomes by Rada‐Iglesias, Alvaro, Grosveld, Frank G, Papantonis, Argyris

“…The last decade has radically renewed our understanding of higher order chromatin folding in the eukaryotic nucleus. As a result, most current models are in…”
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Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells by Zuin, Jessica, Dixon, Jesse R., van der Reijden, Michael I. J. A., Ye, Zhen, Kolovos, Petros, Brouwer, Rutger W. W., van de Corput, Mariëtte P. C., van de Werken, Harmen J. G., Knoch, Tobias A., van IJcken, Wilfred F. J., Grosveld, Frank G., Ren, Bing, Wendt, Kerstin S.

“…Recent studies of genome-wide chromatin interactions have revealed that the human genome is partitioned into many self-associating topological domains. The…”
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Directed Migration of Cortical Interneurons Depends on the Cell-Autonomous Action of Sip1 by van den Berghe, Veronique, Stappers, Elke, Vandesande, Bram, Dimidschstein, Jordane, Kroes, Roel, Francis, Annick, Conidi, Andrea, Lesage, Flore, Dries, Ruben, Cazzola, Silvia, Berx, Geert, Kessaris, Nicoletta, Vanderhaeghen, Pierre, van IJcken, Wilfred, Grosveld, Frank G., Goossens, Steven, Haigh, Jody J., Fishell, Gord, Goffinet, André, Aerts, Stein, Huylebroeck, Danny, Seuntjens, Eve

“…GABAergic interneurons mainly originate in the medial ganglionic eminence (MGE) of the embryonic ventral telencephalon (VT) and migrate tangentially to the…”
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r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data by Thongjuea, Supat, Stadhouders, Ralph, Grosveld, Frank G, Soler, Eric, Lenhard, Boris

“…The coupling of chromosome conformation capture (3C) with next-generation sequencing technologies enables the high-throughput detection of long-range genomic…”
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In vivo live imaging of RNA polymerase II transcription factories in primary cells by Ghamari, Alireza, van de Corput, Mariëtte P C, Thongjuea, Supat, van Cappellen, Wiggert A, van Ijcken, Wilfred, van Haren, Jeffrey, Soler, Eric, Eick, Dirk, Lenhard, Boris, Grosveld, Frank G

“…Transcription steps are marked by different modifications of the C-terminal domain of RNA polymerase II (RNAPII). Phosphorylation of Ser5 and Ser7 by…”
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Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord by Francius, Cédric, Harris, Audrey, Rucchin, Vincent, Hendricks, Timothy J, Stam, Floor J, Barber, Melissa, Kurek, Dorota, Grosveld, Frank G, Pierani, Alessandra, Goulding, Martyn, Clotman, Frédéric

“…The spinal cord contains neuronal circuits termed Central Pattern Generators (CPGs) that coordinate rhythmic motor activities. CPG circuits consist of motor…”
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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin by Papadopoulos, Petros, Gutiérrez, Laura, Scerri, Christian A, van IJcken, Wilfred, von Lindern, Marieke, Cassar, Wilhelmina, Felice, Alex E, Grech, Godfrey, Hou, Jun, Fanis, Pavlos, Phylactides, Marios, Georgitsi, Marianthi, Verkerk, Annemieke J M H, Özgür, Zeliha, Bugeja, Marisa, van der Spek, Peter J, Patrinos, George P, Borg, Joseph, Galdies, Ruth, Grosveld, Frank G, Gillemans, Nynke, Philipsen, Sjaak

“…Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults. Several contributory factors,…”
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The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions by Jhunjhunwala, Suchit, van Zelm, Menno C., Peak, Mandy M., Cutchin, Steve, Riblet, Roy, van Dongen, Jacques J.M., Grosveld, Frank G., Knoch, Tobias A., Murre, Cornelis

“…The immunoglobulin heavy-chain ( Igh) locus is organized into distinct regions that contain multiple variable (V H), diversity (D H), joining (J H) and…”
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Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation by Visvader, Jane E, Forrest, Natasha C, Hartley, Lynne, Grosveld, Frank G, Lindeman, Geoffrey J, Thomas, Richard, Sutherland, Kate D, Shackleton, Mark, Barker, Holly, Asselin-Labat, Marie-Liesse, van der Wees, Jacqueline, Robb, Lorraine

“…The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial…”
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The dynamic emergence of GATA1 complexes identified in in vitro embryonic stem cell differentiation and in vivo mouse fetal liver by Yu, Xiao, Martella, Andrea, Kolovos, Petros, Stevens, Mary, Stadhouders, Ralph, Grosveld, Frank G, Andrieu-Soler, Charlotte

“…GATA1 is an essential transcriptional regulator of myeloid hematopoietic differentiation towards red blood cells. During erythroid differentiation, GATA1 forms…”
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Exploiting native forces to capture chromosome conformation in mammalian cell nuclei by Brant, Lilija, Georgomanolis, Theodore, Nikolic, Milos, Brackley, Chris A, Kolovos, Petros, van Ijcken, Wilfred, Grosveld, Frank G, Marenduzzo, Davide, Papantonis, Argyris

“…Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function…”
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Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function by Outchkourov, Nikolay S., Muiño, Jose M., Kaufmann, Kerstin, van IJcken, Wilfred F.J., Koerkamp, Marian J. Groot, van Leenen, Dik, de Graaf, Petra, Holstege, Frank C.P., Grosveld, Frank G., Timmers, H.T. Marc

“…The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers…”
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Compartmentalization of androgen receptors at endogenous genes in living cells by Yavuz, Selçuk, Kabbech, Hélène, van Staalduinen, Jente, Linder, Simon, van Cappellen, Wiggert A, Nigg, Alex L, Abraham, Tsion E, Slotman, Johan A, Quevedo, Marti, Poot, Raymond A, Zwart, Wilbert, van Royen, Martin E, Grosveld, Frank G, Smal, Ihor, Houtsmuller, Adriaan B

“…Abstract A wide range of nuclear proteins are involved in the spatio-temporal organization of the genome through diverse biological processes such as gene…”
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The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons by Tsarovina, Konstantina, Reiff, Tobias, Stubbusch, Jutta, Kurek, Dorota, Grosveld, Frank G, Parlato, Rosanna, Schütz, Günther, Rohrer, Hermann

“…The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to…”
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RTTN Mutations Link Primary Cilia Function to Organization of the Human Cerebral Cortex by Kheradmand Kia, Sima, Verbeek, Elly, Engelen, Erik, Schot, Rachel, Poot, Raymond A., de Coo, Irenaeus F.M., Lequin, Maarten H., Poulton, Cathryn J., Pourfarzad, Farzin, Grosveld, Frank G., Brehm, António, de Wit, Marie Claire Y., Oegema, Renske, Dobyns, William B., Verheijen, Frans W., Mancini, Grazia M.S.

“…Polymicrogyria is a malformation of the developing cerebral cortex caused by abnormal organization and characterized by many small gyri and fusion of the outer…”
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Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63 by Ochieng, Joshua K, Schilders, Kim, Kool, Heleen, Boerema-De Munck, Anne, Buscop-Van Kempen, Marjon, Gontan, Cristina, Smits, Ron, Grosveld, Frank G, Wijnen, Rene M H, Tibboel, Dick, Rottier, Robbert J

“…Lung development is determined by the coordinated expression of several key genes. Previously, we and others have shown the importance of the sex determining…”
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Multiple interactions between regulatory regions are required to stabilize an active chromatin hub by Patrinos, George P, de Krom, Mariken, de Boer, Ernie, Langeveld, An, Imam, A M Ali, Strouboulis, John, de Laat, Wouter, Grosveld, Frank G

“…The human beta-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes…”
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Enhancers and silencers: an integrated and simple model for their function by Kolovos, Petros, Knoch, Tobias A, Grosveld, Frank G, Cook, Peter R, Papantonis, Argyris

“…Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development…”
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Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors by Gontan, Cristina, Güttler, Thomas, Engelen, Erik, Demmers, Jeroen, Fornerod, Maarten, Grosveld, Frank G, Tibboel, Dick, Görlich, Dirk, Poot, Raymond A, Rottier, Robbert J

“…SRY and other Sox-type transcription factors are important developmental regulators with various implications in human disease. In this study, we identified…”
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MN1 overexpression is an important step in the development of inv(16) AML by CARELLA, C, BONTEN, J, GROSVELD, G. C, SIRMA, S, KRANENBURG, T. A, TERRANOVA, S, KLEIN-GELTINK, R, SHURTLEFF, S, DOWNING, J. R, ZWARTHOFF, E. C, LIU, P. P

“…The gene encoding the transcriptional co-activator MN1 is the target of the reciprocal chromosome translocation (12;22)(p13;q12) in some patients with acute…”
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