Search Results - "Grosveld, F."

NARWHAL, a primary analysis pipeline for NGS data by Brouwer, R. W. W., van den Hout, M. C. G. N., Grosveld, F. G., van IJcken, W. F. J.

“…The NARWHAL software pipeline has been developed to automate the primary analysis of Illumina sequencing data. This pipeline combines a new and flexible…”
Get full text

Activation by locus control regions? by Grosveld, Frank

“…On the basis of homologous recombination experiments to delete the murine β-globin locus control region (LCR) in embryonic stem cells, it was recently…”
Get full text

Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding by Jagalur, Noorjahan B, Ghazvini, Mehrnaz, Mandemakers, Wim, Driegen, Siska, Maas, Alex, Jones, Erin A, Jaegle, Martine, Grosveld, Frank, Svaren, John, Meijer, Dies

“…The POU domain transcription factor Pou3f1 (Oct6/Scip/Tst1) initiates the transition from ensheathing, promyelinating Schwann cells to myelinating cells…”
Get full text

GATA-1 forms distinct activating and repressive complexes in erythroid cells by Rodriguez, Patrick, Bonte, Edgar, Krijgsveld, Jeroen, Kolodziej, Katarzyna E, Guyot, Boris, Heck, Albert JR, Vyas, Paresh, de Boer, Ernie, Grosveld, Frank, Strouboulis, John

“…GATA‐1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell lineages. It acts as an activator and repressor of…”
Get full text

The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development by Jaegle, Martine, Ghazvini, Mehrnaz, Mandemakers, Wim, Piirsoo, Marko, Driegen, Siska, Levavasseur, Francoise, Raghoenath, Smiriti, Grosveld, Frank, Meijer, Dies

“…The genetic hierarchy that controls myelination of peripheral nerves by Schwann cells includes the POU domain Oct-6/Scip/Tst-1and the zinc-finger Krox-20/Egr2…”
Get full text

The transcription factor GATA6 is essential for early extraembryonic development by Koutsourakis, M, Langeveld, A, Patient, R, Beddington, R, Grosveld, F

“…The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a beta-galactosidase marker gene. The analysis of heterozygote…”
Get full text

A new function of ROD1 in nonsense-mediated mRNA decay by Brazão, T.F., Demmers, J., van IJcken, W., Strouboulis, J., Fornerod, M., Romão, L., Grosveld, F.G.

“…► ROD1 is involved in nonsense-mediated mRNA decay (NMD). ► ROD1 is shown to interact with core NMD factors, such as UPF1 and UPF2, and to share common…”
Get full text

Targeted disruption of the housekeeping gene encoding glucose 6‐phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress by Pandolfi, P. P., Sonati, F., Rivi, R., Mason, P., Grosveld, F., Luzzatto, L.

“…Glucose 6‐phosphate dehydrogenase (G6PD) is a housekeeping enzyme encoded in mammals by an X‐linked gene. It has important functions in intermediary metabolism…”
Get full text

Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients by van Leeuwen, Fred W., Dominique P. V. de Kleijn, van den Hurk, Helma H., Neubauer, Andrea, Marc A. F. Sonnemans, Sluijs, Jacqueline A., Köycü, Soner, Ravindra D. J. Ramdjielal, Salehi, Ahmad, Gerard J. M. Martens, Grosveld, Frank G., J. Peter H. Burbach, Hol, Elly M.

“…The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic…”
Get full text

The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development by Keijzer, R, van Tuyl, M, Meijers, C, Post, M, Tibboel, D, Grosveld, F, Koutsourakis, M

“…Recent loss-of-function studies in mice show that the transcription factor GATA6 is important for visceral endoderm differentiation. It is also expressed in…”
Get full text

Baculovirus Infection of Nondividing Mammalian Cells: Mechanisms of Entry and Nuclear Transport of Capsids by van Loo, N D, Fortunati, E, Ehlert, E, Rabelink, M, Grosveld, F, Scholte, B J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A dominant chromatin‐opening activity in 5′ hypersensitive site 3 of the human beta‐globin locus control region by Ellis, J., Tan‐Un, K. C., Harper, A., Michalovich, D., Yannoutsos, N., Philipsen, S., Grosveld, F.

“…Single‐copy human beta‐globin transgenes are very susceptible to suppression by position effects of surrounding closed chromatin. However, these position…”
Get full text

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice by Nawijn, Martijn C, Ferreira, Rita, Dingjan, Gemma M, Kahre, Olev, Drabek, Dubravka, Karis, Alar, Grosveld, Frank, Hendriks, Rudolf W

“…The zinc finger transcription factor GATA-3 is of critical importance for early T cell development and commitment of Th2 cells. To study the role of GATA-3 in…”
Get full text

Multiple interactions between regulatory regions are required to stabilize an active chromatin hub by Patrinos, George P, de Krom, Mariken, de Boer, Ernie, Langeveld, An, Imam, A M Ali, Strouboulis, John, de Laat, Wouter, Grosveld, Frank G

“…The human beta-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes…”
Get full text

GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei by Hikke van Doorninck, J, van der Wees, Jacqueline, Karis, Alar, Goedknegt, Erika, Coesmans, Michiel, Rutteman, Mandy, Grosveld, Frank, De Zeeuw, Chris I

“…The GATA-3 transcription factor shows a specific and restricted expression pattern in the developing and adult mouse brain. In the present study we…”
Get full text

The role of EKLF in human beta-globin gene competition by Wijgerde, M, Gribnau, J, Trimborn, T, Nuez, B, Philipsen, S, Grosveld, F, Fraser, P

“…We have investigated the role of erythroid Kruppel-like factor (EKLF) in expression of the human beta-globin genes in compound EKLF knockout/human beta-locus…”
Get full text

The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein by Wall, L, deBoer, E, Grosveld, F

“…We have shown that the minimal enhancer fragment present in the 3'-flanking region of the human beta-globin gene contains four regions that bind nuclear…”
Get full text

Definition of the minimal requirements within the human beta‐globin gene and the dominant control region for high level expression by Collis, P., Antoniou, M., Grosveld, F.

“…The human beta‐globin dominant control region (DCR) was previously identified as a region from the 5′ end of the human beta‐globin locus which directs high…”
Get full text

Detailed analysis of the site 3 region of the human beta‐globin dominant control region by Talbot, D., Philipsen, S., Fraser, P., Grosveld, F.

“…Four DNase I hypersensitive sites characterize the human beta‐globin Dominant Control Region (DCR) providing position independent, high levels of erythroid…”
Get full text

Enforced Expression of GATA-3 in Transgenic Mice Inhibits Th1 Differentiation and Induces the Formation of a T1/ST2-Expressing Th2-Committed T Cell Compartment In Vivo by Nawijn, Martijn C, Dingjan, Gemma M, Ferreira, Rita, Lambrecht, Bart N, Karis, Alar, Grosveld, Frank, Savelkoul, Huub, Hendriks, Rudolf W

“…The transcription factor GATA-3 is essential for early T cell development and differentiation of naive CD4(+) T cells into Th2 effector cells. To study the…”
Get full text