Search Results - "Grossniklaus, H"

Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV by Singh, S R, Grossniklaus, H E, Kang, S J, Edelhauser, H F, Ambati, B K, Kompella, U B

“…Choroidal neovascularization (CNV) leads to loss of vision in age-related macular degeneration (AMD), the leading cause of blindness in adult population over…”
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Sustained reduction of intraocular pressure by supraciliary delivery of brimonidine-loaded poly(lactic acid) microspheres for the treatment of glaucoma by Chiang, B., Kim, Y.C., Doty, A.C., Grossniklaus, H.E., Schwendeman, S.P., Prausnitz, M.R.

“…Although effective drugs that lower intraocular pressure (IOP) in the management of glaucoma exist, their efficacy is limited by poor patient adherence to the…”
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Transpupillary collagen photocrosslinking for targeted modulation of ocular biomechanics by Gerberich, B.G., Hannon, B.G., Hejri, A., Winger, E.J., Schrader Echeverri, E., Nichols, L.M., Gersch, H.G., MacLeod, N.A., Gupta, S., Read, A.T., Ritch, M.D., Sridhar, S., Toothman, M.G., Gershon, G.S., Schwaner, S.A., Sánchez-Rodríguez, G., Goyal, V., Toporek, A.M., Feola, A.J., Grossniklaus, H.E., Pardue, M.T., Ethier, C.R., Prausnitz, M.R.

“…The central vision-threatening event in glaucoma is dysfunction and loss of retinal ganglion cells (RGCs), thought to be promoted by local tissue deformations…”
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Analysis of Damage and Wound Healing in the Retinal Pigmented Epithelium by Donaldson, K J, Wu, W F, Skelton, H, Markand, S, Ferdous, S, Sellers, J, Chrenek, M A, Gefke, I, Kim, S M, Rha, J, Liao, K L, Grossniklaus, H E, Jiang, Y, Kong, J, Boatright, J H, Nickerson, John M

“…Previous studies of retinal pigment epithelium (RPE) morphology found cell-level and spatial patterning differences in many quantitative metrics in comparing…”
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Lymphoma of Ocular and Periocular Tissues - Clinicopathological Correlations by Schmack, I, Grossniklaus, H E, Hartmann, S

“…Lymphomas of the ocular adnexa and intraocular tissue include a wide range of lymphoproliferative neoplastic disorders. They are predominantly extranodal…”
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Histologic and Morphometric Analysis of the Choroid, Bruch's Membrane, and Retinal Pigment Epithelium in Postmortem Eyes With Age-Related Macular Degeneration and Histologic Examination of Surgically Excised Choroidal Neovascular Membranes by Spraul, Christoph W, Lang, Gabriele E, Grossniklaus, Hans E, Lang, Gerhard K

“…Objective : Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized countries. Different risk factors have been…”
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Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes by Grossniklaus, HansE, Gass, J.DonaldM

“…Purpose: To correlate the histologic and clinical classification of type 1 (subretinal pigment epithelium) and type 2 (subsensory retina) choroidal…”
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Ultrastructural Changes in Bruch's Membrane of Apolipoprotein E-Deficient Mice by Dithmar, Stefan, Curcio, Christine A, Le, Ngoc-Anh, Brown, Stephanie, Grossniklaus, Hans E

“…To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched…”
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The Zimmerman-McLean-Foster hypothesis: 25 years later by Singh, A D, Rennie, I G, Kivela, T, Seregard, S, Grossniklaus, H

“…It is now 25 years since the publication of the landmark article by Zimmerman, McLean, and Foster, in which they cast doubts on the benefit of enucleation,…”
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Vitreous hemorrhage by Spraul, Christoph W., Grossniklaus, Hans E.

“…The incidence of spontaneous vitreous hemorrhage is approximately 7 cases per 100,000 population. Proliferative diabetic retinopathy (32%), retinal tear (30%),…”
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Formation and growth of lipofuscin in the retinal pigment epithelium cells by Mazzitello, K I, Arizmendi, C M, Family, F, Grossniklaus, H E

“…The kinetics of lipofuscin growth in diseased retinal pigment epithelium cells is investigated using Monte Carlo simulations and scaling theory on a cluster…”
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Ultrastructural Features of Tissue Removed During Idiopathic Macular Hole Surgery by YOON, HEE-SEONG, BROOKS, H. LOGAN, CAPONE, ANTONIO, L'HERNAULT, NANCY L., GROSSNIKLAUS, HANS E.

“…To compare the ultrastructural features of excised tissue removed during surgery for idiopathic macular holes with the preoperative stage of the macular hole…”
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Morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration by Spraul, CW, Lang, GE, Grossniklaus, HE

“…To quantify morphologic changes in the choroid, including choriocapillaris and larger choroidal vessels, Bruch's membrane, and retinal pigment epithelium in…”
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Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses by YONG KE, KEQIANG YE, GROSSNIKLAUS, H. E, ARCHER, D. R, JOSHI, H. C, KAPP, J. A

“…Noscapine, a phthalideisoquinoline alkaloid derived from opium, has been used as an oral anti-tussive agent and has shown very few toxic effects in animals or…”
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Histopathological findings in postmortem eyes after photodynamic therapy for choroidal neovascularisation in age-related macular degeneration: report of two cases by Kang, S J, Schmack, I, Benson, H E, Grossniklaus, H E

“…Background:To report the histopathological findings after photodynamic therapy (PDT) in eyes obtained postmortem with choroidal neovascularisation (CNV)…”
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Lacrimal gland choristoma in a preterm infant, presenting with spontaneous hyphema and increased intraocular pressure by Ranganathan, D, Lenhart, P, Hubbard, G B, Grossniklaus, H

“…We report a case of intraocular lacrimal gland choristoma presenting very early in a preterm infant with hyphema, a mass lesion and raised intraocular…”
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Helicobacter pylori (H. pylori) molecular signature in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma by Chan, C-C, Smith, J A, Shen, D F, Ursea, R, LeHoang, P, Grossniklaus, H E

“…Conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal marginal zone B-cell lymphoma that is characterized by an exaggerated clonal…”
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Finding malignant change in a necrotic choroidal melanocytoma: a clinical challenge by Kurli, M, Finger, P T, Manor, T, McCormick, S A, Grossniklaus, H E

“…Exam ination showed no light perception, a relative afferent pupillary defect, a shallow anterior chamber, and an intraocular pressure of 58 mm Hg. Computed…”
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Clinico-pathological correlations: posterior compartment of the eye and orbit by Herwig, M C, Löffler, K U, Wells, J R, Grossniklaus, H E

“…Diseases of the posterior compartment and the orbit are characterised by histological findings, most of which can be reproduced clinically. Examples are the…”
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Ocular Pathology in Mitochondrial Superoxide Dismutase (Sod2)-Deficient Mice by Sandbach, Jennifer M, Coscun, Pinar E, Grossniklaus, Hans E, Kokoszka, Jason E, Newman, Nancy J, Wallace, Douglas C

“…To characterize the pathologic features in retina, optic nerve, and extraocular muscle of mitochondrial superoxide dismutase (Sod2)-deficient mice, a model of…”
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