Search Results - "Grossman, S R"

The SWI SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells by Naidu, S R, Love, I M, Imbalzano, A N, Grossman, S R, Androphy, E J

“…The tumor suppressor p53 preserves genome integrity by inducing transcription of genes controlling growth arrest or apoptosis. Transcriptional activation…”
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An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis by Kovi, R C, Paliwal, S, Pande, S, Grossman, S R

“…The alternative reading frame (ARF) tumor suppressor exerts both p53-dependent and p53-independent functions. The corepressor C-terminal binding protein (CtBP)…”
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hHR23B is required for genotoxic-specific activation of p53 and apoptosis by KAUR, M, POP, M, SHI, D, BRIGNONE, C, GROSSMAN, S. R

“…Rad23 proteins function in both DNA repair and protein stability regulation. As ubiquitinated forms of p53 are stabilized after DNA damage in concert with p53…”
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Binding and modulation of p53 by p300/CBP coactivators by Livingston, David M, Lill, Nancy L, Grossman, Steven R, Ginsberg, Doron, DeCaprio, James

“…The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated…”
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The Epstein-Barr Virus Nuclear Antigen 2 Transactivator is Directed to Response Elements by the Jκ Recombination Signal Binding Protein by Grossman, S R, Johannsen, E, Tong, X, Yalamanchili, R, Kieff, E

“…Epstein-Barr virus nuclear antigen 2 (EBNA-2) plays an essential role in primary B-lymphocyte growth transformation. EBNA-2 is an acidic transcriptional…”
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Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia by Sumner, E T, Chawla, A T, Cororaton, A D, Koblinski, J E, Kovi, R C, Love, I M, Szomju, B B, Korwar, S, Ellis, K C, Grossman, S R

“…Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with…”
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Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle by Miyake, Satoshi, Sellers, William R., Safran, Michal, Li, Xiaotong, Zhao, Wenqing, Grossman, Steven R., Gan, Jianmin, DeCaprio, James A., Adams, Peter D., Kaelin, William G.

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Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1 by Johannsen, E, Koh, E, Mosialos, G, Tong, X, Kieff, E, Grossman, S R

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Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells by BEDELL, M. A, JONES, K. H, GROSSMAN, S. R, LAIMINS, L. A

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Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl by Vaughan, Catherine A, Singh, Shilpa, Windle, Brad, Yeudall, W Andrew, Frum, Rebecca, Grossman, Steven R, Deb, Swati P, Deb, Sumitra

“…p53 mutations are present in up to 70% of lung cancer. Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 or no…”
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Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding by MCINTYRE, M. C, FRATTINI, M. G, GROSSMAN, S. R, LAIMINS, L. A

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Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex by Vazquez, Francisca, Grossman, Steven R., Takahashi, Yuki, Rokas, Mihail V., Nakamura, Noriaki, Sellers, William R.

“…PTEN is a tumor suppressor protein that functions, in large part, by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate and…”
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Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector by GROSSMAN, S. R, MORA, R, LAIMINS, L. A

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Epstein-Barr Virus Nuclear Protein 2 Interacts with p300, CBP, and PCAF Histone Acetyltransferases in Activation of the LMP1 Promoter by Wang, Lian, Grossman, Steven R., Kieff, Elliott

“…The Epstein-Barr virus (EBV) nuclear protein 2 (EBNA2) and herpes simplex virion protein 16 (VP16) acidic domains that mediate transcriptional activation now…”
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Cooperative binding of the E2 protein of bovine papillomavirus to adjacent E2-responsive sequences by Monini, P. (Howard Hughes Medical Institute, Chicago, IL), Grossman, S.R, Pepinsky, B, Androphy, E.J, Laimins, L.A

“…The DNA-binding properties of purified full-length E2 protein from bovine papillomavirus type 1 have been investigated by utilizing a quantitative gel shift…”
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p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation by Grossman, Steven R, Perez, Marco, Kung, Andrew L, Joseph, Michael, Mansur, Claire, Xiao, Zhi-Xiong, Kumar, Sushant, Howley, Peter M, Livingston, David M

“…Control of p53 turnover is critical to p53 function. E1A binding to p300/CBP translates into enhanced p53 stability, implying that these coactivator proteins…”
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Changing patterns of prophylaxis for deep venous thrombosis following elective hip replacement by Grossman, R S

“…The author audited the charts of elective hip replacements at a community hospital over an 18 month period. Initially, aspirin was the most commonly ordered…”
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p19ARF Targets Certain E2F Species for Degradation by Martelli, Fabio, Hamilton, Timothy, Silver, Daniel P., Sharpless, Norman E., Bardeesy, Nabeel, Rokas, Mihail, DePinho, Ronald A., Livingston, David M., Grossman, Steven R.

“…p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism. p19ARF was found to complex with transcription factors E2F1, -2, and -3. Levels…”
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Validity of the in-training examination for predicting American board of internal medicine certifying examination scores by GROSSMAN, R. S, FINCHER, R.-M. E, LAYNE, R. D, SEELIG, C. B, BERKOWITZ, L. R, LEVINE, M. A

“…To determine whether the results of the Internal Medicine In-Training Examination (ITE) can predict subsequent performance on the American Board of Internal…”
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EBNA1 and E2: a new paradigm for origin-binding proteins? by Grossman, Steven R., Laimins, Laimonis A.

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