Search Results - "Grosslight, Samantha"

Noncovalent Interactions Drive the Efficiency of Molybdenum Imido Alkylidene Catalysts for Olefin Metathesis by Ferreira, Marco A. B, De Jesus Silva, Jordan, Grosslight, Samantha, Fedorov, Alexey, Sigman, Matthew S, Copéret, Christophe

“…High-throughput experimentation and multivariate modeling allow identification of noncovalent interactions (NCIs) in monoaryloxy-pyrrolide Mo imido alkylidene…”
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Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands by Widlicka, Daniel W., Singer, Robert A., Hotham, Ian, Bernhardson, David J., Grosslight, Samantha

“…Hydroxylation of haloarenes is a fundamental transformation in synthetic organic chemistry. Hydroxypicolinamide ligands enable the efficient Cu-catalyzed…”
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Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands by Dotson, Jordan J., van Dijk, Lucy, Timmerman, Jacob C., Grosslight, Samantha, Walroth, Richard C., Gosselin, Francis, Püntener, Kurt, Mack, Kyle A., Sigman, Matthew S.

“…Optimization of the catalyst structure to simultaneously improve multiple reaction objectives (e.g., yield, enantioselectivity, and regioselectivity) remains a…”
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Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036 by Xu, Jie, Grosslight, Samantha, Mack, Kyle A., Nguyen, Sierra C., Clagg, Kyle, Lim, Ngiap-Kie, Timmerman, Jacob C., Shen, Jeff, White, Nicholas A., Sirois, Lauren E., Han, Chong, Zhang, Haiming, Sigman, Matthew S., Gosselin, Francis

“…An efficient asymmetric synthesis of a potent KRAS G12C covalent inhibitor, GDC-6036 (1), is reported. The synthesis features a highly atroposelective Negishi…”
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Site-Selective Acylation of Natural Products with BINOL-Derived Phosphoric Acids by Li, Junqi, Grosslight, Samantha, Miller, Scott J, Sigman, Matthew S, Toste, F. Dean

“…The site-selective acylation of a steroidal natural product 19-hydroxy­dehydro­epiandrosterone catalyzed by 1,1′-Bi­(2-napthol)-derived (BINOL) chiral…”
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Synthesis of guaipyridine alkaloids (±)-cananodine and (±)-rupestines D and G using an intramolecular Mizoroki-Heck reaction by Shelton, Patrick M.M., Grosslight, Samantha M., Mulligan, Briana J., Spargo, Hope V., Saad, Silvana S., Vyvyan, James R.

“…The guaipyridine alkaloids cananodine, rupestine D and rupestine G were synthesized in six steps or less from readily available…”
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Development and Molecular Understanding of a Pd‐Catalyzed Cyanation of Aryl Boronic Acids Enabled by High‐Throughput Experimentation and Data Analysis by De Jesus Silva, Jordan, Bartalucci, Niccolò, Jelier, Benson, Grosslight, Samantha, Gensch, Tobias, Schünemann, Claas, Müller, Bernd, Kamer, Paul C. J., Copéret, Christophe, Sigman, Matthew S., Togni, Antonio

“…A synthetic method for the palladium‐catalyzed cyanation of aryl boronic acids using bench stable and non‐toxic N‐cyanosuccinimide has been developed…”
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Interrogating Catalytic Processes with Data Science, Computational Chemistry, and Synthesis by Grosslight, Samantha Marie

“…This dissertation utilizes data-driven workflows to gain a deeper understanding of the features influencing selective catalytic processes. Selectivity within…”
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