Search Results - "Grossi, Mario"

BAMLET administration via drinking water inhibits intestinal tumor development and promotes long-term health by Tran, Hien Thi, Wan, Murphy Lam Yim, Ambite, Ines, Cavalera, Michele, Grossi, Mario, Háček, Jaromir, Esmaeili, Parisa, Carneiro, António N. B. M., Chaudhuri, Arunima, Ahmadi, Shahram, Svanborg, Catharina

“…Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor…”
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Inhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing by Gidlöf, Olof, Bader, Kerstin, Celik, Selvi, Grossi, Mario, Nakagawa, Shinichi, Hirose, Tetsuro, Metzler, Bernhard, Olde, Björn, Erlinge, David

“…While restoration of coronary blood flow to the ischemic heart is the most effective strategy for reducing infarct size, reperfusion injury represents a…”
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EH Domain-Containing 2 Deficiency Restricts Adipose Tissue Expansion and Impairs Lipolysis in Primary Inguinal Adipocytes by Fryklund, Claes, Morén, Björn, Shah, Shrenika, Grossi, Mario, Degerman, Eva, Matthaeus, Claudia, Stenkula, Karin G.

“…Lipid uptake can be facilitated via caveolae, specific plasma membrane invaginations abundantly expressed in adipocytes. The dynamin-related protein EH…”
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Polyamine concentration is increased in thoracic ascending aorta of patients with bicuspid aortic valve by Forte, Amalia, Grossi, Mario, Bancone, Ciro, Cipollaro, Marilena, De Feo, Marisa, Hellstrand, Per, Persson, Lo, Nilsson, Bengt-Olof, Della Corte, Alessandro

“…Polyamines are cationic molecules synthesized via a highly regulated pathway, obtained from the diet or produced by the gut microbiota. They are involved in…”
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Two neuron clusters in the stem of postembryonic zebrafish brain specifically express relaxin‐3 gene: First evidence of nucleus incertus in fish by Donizetti, Aldo, Grossi, Mario, Pariante, Paolo, D'Aniello, Enrico, Izzo, Gaia, Minucci, Sergio, Aniello, Francesco

“…We examined the spatial expression of the relaxin‐3 gene in the developing zebrafish brain, one of the vertebrate model systems in which this gene has been…”
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Stem Cell Therapy for Arterial Restenosis: Potential Parameters Contributing to the Success of Bone Marrow-Derived Mesenchymal Stromal Cells by Forte, Amalia, Rinaldi, Barbara, Sodano, Loredana, Berrino, Liberato, Rossi, Francesco, Finicelli, Mauro, Grossi, Mario, Cobellis, Gilda, Botti, Chiara, De Feo, Marisa, Santè, Pasquale, Galderisi, Umberto, Cipollaro, Marilena

“…Purpose Restenosis is a complex and heterogeneous pathophysiological phenomenon occurring in patients submitted to revascularization procedures. Previous…”
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The polyamine pathway as a potential target for vascular diseases: focus on restenosis by Forte, Amalia, Hellstrand, Per, Nilsson, Bengt-Olof, Grossi, Mario, Rossi, Francesco, Cipollaro, Marilena

“…Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation…”
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Abstract 13073: Antisense Transcripts Regulate Titin Alternative Splicing and Sarcomere Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Celik, Selvi, Hyrefelt, Ludvig, Czuba, Tomasz, Andre, Oscar, Lindquist, Lovisa, Grossi, Mario, Nordenfelt, Pontus, Smith, Gustav, Gidlof, Olof

“…The giant protein Titin is an essential structural component of the sarcomere and a key determinant of passive tension during diastole. Titin tension is…”
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Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction by Daoud, Fatima, Holmberg, Johan, Alajbegovic, Azra, Grossi, Mario, Rippe, Catarina, Swärd, Karl, Albinsson, Sebastian

“…YAP (Yap1) and TAZ (Wwtr1) are transcriptional co-activators and downstream effectors of the Hippo pathway, which play crucial roles in organ size control and…”
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Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization by Hien, Tran Thi, Turczyńska, Karolina M., Dahan, Diana, Ekman, Mari, Grossi, Mario, Sjögren, Johan, Nilsson, Johan, Braun, Thomas, Boettger, Thomas, Garcia-Vaz, Eliana, Stenkula, Karin, Swärd, Karl, Gomez, Maria F., Albinsson, Sebastian

“…Both type 1 and type 2 diabetes are associated with increased risk of cardiovascular disease. This is in part attributed to the effects of hyperglycemia on…”
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Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells by Grossi, Mario, Phanstiel, Otto, Rippe, Catarina, Swärd, Karl, Alajbegovic, Azra, Albinsson, Sebastian, Forte, Amalia, Persson, Lo, Hellstrand, Per, Nilsson, Bengt-Olof

“…Increased vascular smooth muscle cell (VSMC) proliferation is a factor in atherosclerosis and injury‐induced arterial (re) stenosis. Inhibition of polyamine…”
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Extracellular Vesicle-Associated TWEAKContributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection by Celik, Selvi, Sadrian, Julia, Grossi, Mario, Czuba, Tomasz, Lundgren, Jakob, Rådegran, Göran, Laurell, Thomas, Smith, J. Gustav, Gidlöf, Olof

“…Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The…”
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Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction by Krawczyk, Katarzyna K., Ekman, Mari, Rippe, Catarina, Grossi, Mario, Nilsson, Bengt-Olof, Albinsson, Sebastian, Uvelius, Bengt, Swärd, Karl

“…Phenotypic modulation of smooth muscle cells is a hallmark of disease. The associated expansion of endoplasmic reticulum (ER) volume remains unexplained…”
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Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle by Grossi, Mario, Bhattachariya, Anirban, Nordström, Ina, Turczyńska, Karolina M., Svensson, Daniel, Albinsson, Sebastian, Nilsson, Bengt‐Olof, Hellstrand, Per

“…Modulation from contractile to synthetic phenotype of vascular smooth muscle cells is a central process in disorders involving compromised integrity of the…”
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Early cell changes and TGFβ pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis by Forte, Amalia, Della Corte, Alessandro, Grossi, Mario, Bancone, Ciro, Provenzano, Raffaela, Finicelli, Mauro, De Feo, Marisa, De Santo, Luca S, Nappi, Gianantonio, Cotrufo, Maurizio, Galderisi, Umberto, Cipollaro, Marilena

“…Previous studies on BAV (bicuspid aortic valve)-related aortopathy, whose aetiology is still debated, have focused mainly on severe dilatations. In the present…”
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Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection by Celik, Selvi, Sadrian, Julia, Grossi, Mario, Czuba, Tomasz, Lundgren, Jakob, Rådegran, Göran, Laurell, Thomas, Smith, J. Gustav, Gidlöf, Olof

“…[Display omitted] •During ACR, vesicular, but not soluble TWEAK, was increased in the circulation in patients who received transplants.•The TWEAK receptor FN14…”
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Vasopressin-induced mouse urethral contraction is modulated by caveolin-1 by Zeng, Jianwen, Ekman, Mari, Grossi, Mario, Svensson, Daniel, Nilsson, Bengt-Olof, Jiang, Chonghe, Uvelius, Bengt, Swärd, Karl

“…Caveolae are 50–100nm large invaginations in the cell membrane that are considered to play roles in receptor signaling. Here we aimed to investigate the…”
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Differential expression of proteins related to smooth muscle cells and myofibroblasts in human thoracic aortic aneurysm by Forte, Amalia, Della Corte, Alessandro, Grossi, Mario, Bancone, Ciro, Maiello, Ciro, Galderisi, Umberto, Cipollaro, Marilena

“…Increasing knowledge is required for a better comprehension of the etiology of thoracic aortic aneurysm (TAA). The aim of this study was to highlight the…”
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Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake by Grossi, Mario, Rippe, Catarina, Sathanoori, Ramasri, Swärd, Karl, Forte, Amalia, Erlinge, David, Persson, Lo, Hellstrand, Per, Nilsson, Bengt-Olof

“…Much evidence highlights the importance of polyamines for VSMC (vascular smooth muscle cell) proliferation and migration. Cav-1 (caveolin-1) was recently…”
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Inhibition of Polyamine Formation Antagonizes Vascular Smooth Muscle Cell Proliferation and Preserves the Contractile Phenotype by Grossi, Mario, Persson, Lo, Swärd, Karl, Turczyńska, Karolina M., Forte, Amalia, Hellstrand, Per, Nilsson, Bengt‐Olof

“…The polyamines putrescine, spermidine and spermine play essential roles in cell proliferation and migration, two processes involved in the development of…”
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