Search Results - "Grosset, Jacques H."

Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis by Tyagi, Sandeep, Ammerman, Nicole C., Li, Si-Yang, Adamson, John, Converse, Paul J., Swanson, Rosemary V., Almeida, Deepak V., Grosset, Jacques H.

“…A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment…”
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Dose-Ranging Comparison of Rifampin and Rifapentine in Two Pathologically Distinct Murine Models of Tuberculosis by ROSENTHAL, Ian M, TASNEEN, Rokeya, PELOQUIN, Charles A, MING ZHANG, ALMEIDA, Deepak, MDLULI, Khisimuzi E, KARAKOUSIS, Petros C, GROSSET, Jacques H, NUERMBERGER, Eric L

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Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis by NUERMBERGER, Eric, TYAGI, Sandeep, TASNEEN, Rokeya, WILLIAMS, Kathy N, ALMEIDA, Deepak, ROSENTHAL, Ian, GROSSET, Jacques H

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Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations by Andréjak, Claire, Almeida, Deepak V, Tyagi, Sandeep, Converse, Paul J, Ammerman, Nicole C, Grosset, Jacques H

“…The Mycobacterium avium complex is the most common cause of nontuberculous mycobacterial lung disease worldwide; yet, an optimal treatment regimen for M. avium…”
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Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model by Rosenthal, Ian M, Zhang, Ming, Williams, Kathy N, Peloquin, Charles A, Tyagi, Sandeep, Vernon, Andrew A, Bishai, William R, Chaisson, Richard E, Grosset, Jacques H, Nuermberger, Eric L

“…Availability of an ultra-short-course drug regimen capable of curing patients with tuberculosis in 2 to 3 mo would significantly improve global control…”
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PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis by AHMAD, Zahoor, PELOQUIN, Charles A, SINGH, Rajendra P, DERENDORF, Hartmut, TYAGI, Sandeep, GINSBERG, Ann, GROSSET, Jacques H, NUERMBERGER, Eric L

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Biphasic Kill Curve of Isoniazid Reveals the Presence of Drug-Tolerant, Not Drug-Resistant, Mycobacterium tuberculosis in the Guinea Pig by Ahmad, Zahoor, Klinkenberg, Lee G., Pinn, Michael L., Fraig, Mostafa M., Peloquin, Charles A., Bishai, William R., Nuermberger, Eric L., Grosset, Jacques H., Karakousis, Petros C.

“…The marked reduction in the potent early bactericidal activity of isoniazid during the initial phase of antituberculosis (anti-TB) therapy has been attributed…”
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Role of the dosR-dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models by Converse, Paul J, Karakousis, Petros C, Klinkenberg, Lee G, Kesavan, Anup K, Ly, Lan H, Allen, Shannon Sedberry, Grosset, Jacques H, Jain, Sanjay K, Lamichhane, Gyanu, Manabe, Yukari C, McMurray, David N, Nuermberger, Eric L, Bishai, William R

“…The Mycobacterium tuberculosis dosR gene (Rv3133c) is part of an operon, Rv3134c-Rv3132c, and encodes a response regulator that has been shown to be…”
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Dose-Dependent Activity of Pyrazinamide in Animal Models of Intracellular and Extracellular Tuberculosis Infections by AHMAD, Zahoor, FRAIG, Mostafa M, BISSON, Gregory P, NUERMBERGER, Eric L, GROSSET, Jacques H, KARAKOUSIS, Petros C

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Shorter-course treatment for Mycobacterium ulcerans disease with high-dose rifamycins and clofazimine in a mouse model of Buruli ulcer by Converse, Paul J, Almeida, Deepak V, Tasneen, Rokeya, Saini, Vikram, Tyagi, Sandeep, Ammerman, Nicole C, Li, Si-Yang, Anders, Nicole M, Rudek, Michelle A, Grosset, Jacques H, Nuermberger, Eric L

“…ClinicalTrials.gov NCT03474198, NCT01659437…”
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Moxifloxacin-containing Regimen Greatly Reduces Time to Culture Conversion in Murine Tuberculosis by Nuermberger, Eric L, Yoshimatsu, Tetsuyuki, Tyagi, Sandeep, O'Brien, Richard J, Vernon, Andrew N, Chaisson, Richard E, Bishai, William R, Grosset, Jacques H

“…Tuberculosis continues to be a major cause of morbidity and mortality in the world. The expansion of tuberculosis control programs has been limited by the…”
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Combination Chemotherapy with the Nitroimidazopyran PA-824 and First-Line Drugs in a Murine Model of Tuberculosis by NUERMBERGER, Eric, ROSENTHAL, Ian, TYAGI, Sandeep, WILLIAMS, Kathy N, ALMEIDA, Deepak, PELOQUIN, Charles A, BISHAI, William R, GROSSET, Jacques H

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Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease by Converse, Paul J, Tyagi, Sandeep, Xing, Yalan, Li, Si-Yang, Kishi, Yoshito, Adamson, John, Nuermberger, Eric L, Grosset, Jacques H

“…Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks…”
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Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease by Converse, Paul J, Xing, Yalan, Kim, Ki Hyun, Tyagi, Sandeep, Li, Si-Yang, Almeida, Deepak V, Nuermberger, Eric L, Grosset, Jacques H, Kishi, Yoshito

“…Diagnosis of the neglected tropical disease, Buruli ulcer, can be made by acid-fast smear microscopy, specimen culture on mycobacterial growth media,…”
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Rifapentine Is Not More Active than Rifampin against Chronic Tuberculosis in Guinea Pigs by DUTTA, Noton K, ILLEI, Peter B, PELOQUIN, Charles A, PINN, Michael L, MDLULI, Khisimuzi E, NUERMBERGER, Eric L, GROSSET, Jacques H, KARAKOUSIS, Petros C

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Rapid Assessment of Antibacterial Activity against Mycobacterium ulcerans by Using Recombinant Luminescent Strains by TIANYU ZHANG, BISHAI, William R, GROSSET, Jacques H, NUERMBERGER, Eric L

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Rapid, serial, non-invasive assessment of drug efficacy in mice with autoluminescent Mycobacterium ulcerans infection by Zhang, Tianyu, Li, Si-Yang, Converse, Paul J, Grosset, Jacques H, Nuermberger, Eric L

“…Buruli ulcer (BU) caused by Mycobacterium ulcerans is the world's third most common mycobacterial infection. There is no vaccine against BU and surgery is…”
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Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease by Sarfo, Fred Stephen, Converse, Paul J, Almeida, Deepak V, Zhang, Jihui, Robinson, Clive, Wansbrough-Jones, Mark, Grosset, Jacques H

“…Mycobacterium ulcerans infection causes a neglected tropical disease known as Buruli ulcer that is now found in poor rural areas of West Africa in numbers that…”
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Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis by AHMAD, Zahoor, MINKOWSKI, Austin, PELOQUIN, Charles A, WILLIAMS, Kathy N, MDLULI, Khisimuzi E, GROSSET, Jacques H, NUERMBERGER, Eric L

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Potent Twice-Weekly Rifapentine-containing Regimens in Murine Tuberculosis by Rosenthal, Ian M, Williams, Kathy, Tyagi, Sandeep, Peloquin, Charles A, Vernon, Andrew A, Bishai, William R, Grosset, Jacques H, Nuermberger, Eric L

“…Recent studies have demonstrated that intermittent administration of rifamycin-based regimens results in higher rates of tuberculosis relapse and treatment…”
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