Search Results - "Grosse, Miriam"

Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application by Hofer, Walter, Deschner, Felix, Jézéquel, Gwenaëlle, Pessanha de Carvalho, Laìs, Abdel‐Wadood, Noran, Pätzold, Linda, Bernecker, Steffen, Morgenstern, Bernd, Kany, Andreas M., Große, Miriam, Stadler, Marc, Bischoff, Markus, Hirsch, Anna K. H., Held, Jana, Herrmann, Jennifer, Müller, Rolf

“…The natural product chlorotonil displays high potency against multidrug‐resistant Gram‐positive bacteria and Plasmodium falciparum. Yet, its scaffold is…”
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A Portable Biosensor for 2,4-Dinitrotoluene Vapors by Prante, Marc, Ude, Christian, Große, Miriam, Raddatz, Lukas, Krings, Ulrich, John, Gernot, Belkin, Shimshon, Scheper, Thomas

“…Buried explosive material, e.g., landmines, represent a severe issue for human safety all over the world. Most explosives consist of environmentally hazardous…”
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A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase by Balthazar, Jacqueline T, Golparian, Daniel, Unemo, Magnus, Read, Timothy D, Grosse, Miriam, Stadler, Marc, Pfarr, Kenneth, Schiefer, Andrea, Hoerauf, Achim, Edwards, Jennifer L, Vassylyev, Dmitry G, Shafer, William M

“…The continued emergence of strains that express resistance to multiple antibiotics, including the last drug for empiric monotherapy (ceftriaxone), necessitates…”
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Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations by Becker, Tim, Heitkötter, Jan, Krome, Anna K, Schiefer, Andrea, Pfarr, Kenneth, Ehrens, Alexandra, Grosse, Miriam, Sandargo, Birthe, Stammberger, Ingo, Stadler, Marc, Hübner, Marc P, Kehraus, Stefan, Hoerauf, Achim, Wagner, Karl G

“…Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration…”
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Erratum for Balthazar et al., “A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase” by Balthazar, Jacqueline T., Golparian, Daniel, Unemo, Magnus, Read, Timothy D., Grosse, Miriam, Stadler, Marc, Pfarr, Kenneth, Schiefer, Andrea, Hoerauf, Achim, Edwards, Jennifer L., Vassylyev, Dmitry G., Shafer, William M.

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Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus by Rox, Katharina, Becker, Tim, Schiefer, Andrea, Grosse, Miriam, Ehrens, Alexandra, Jansen, Rolf, Aden, Tilman, Kehraus, Stefan, König, Gabriele M, Krome, Anna K, Hübner, Marc P, Wagner, Karl G, Stadler, Marc, Pfarr, Kenneth, Hoerauf, Achim

“…Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths…”
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The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus by Balansky, Jan, Pfarr, Kenneth, Szekat, Christiane, Kehraus, Stefan, Aden, Tilman, Grosse, Miriam, Jansen, Rolf, Hesterkamp, Thomas, Schiefer, Andrea, König, Gabriele M, Stadler, Marc, Hoerauf, Achim, Bierbaum, Gabriele

“…Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation…”
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In Vitro-In Vivo Relationship in Mini-Scale-Enabling Formulations of Corallopyronin A by Becker, Tim, Krome, Anna K, Vahdati, Sahel, Schiefer, Andrea, Pfarr, Kenneth, Ehrens, Alexandra, Aden, Tilman, Grosse, Miriam, Jansen, Rolf, Alt, Silke, Hesterkamp, Thomas, Stadler, Marc, Hübner, Marc P, Kehraus, Stefan, König, Gabriele M, Hoerauf, Achim, Wagner, Karl G

“…In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are…”
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Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A by Edwards, Jennifer L, Balthazar, Jacqueline T, Esposito, Danillo L A, Ayala, Julio C, Schiefer, Andrea, Pfarr, Kenneth, Hoerauf, Achim, Alt, Silke, Hesterkamp, Thomas, Grosse, Miriam, Stadler, Marc, Golparian, Daniel, Unemo, Magnus, Read, Timothy D, Shafer, William M

“…Gonorrhea remains a major global public health problem because of the high incidence of infection (estimated 82 million cases in 2020) and the emergence and…”
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Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres by Hovest, Miriam Grosse, Brüggenolte, Nicole, Hosseini, Kijawasch Shah, Krieg, Thomas, Herrmann, Gernot

“…Cellular senescence is a phenotype that is likely linked with aging. Recent concepts view different forms of senescence as permanently maintained DNA damage…”
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Formation of Decatrienones with a Pineapple-like Aroma from 1-13C‑Acetate by Cell Cultures of the Birch Polypore, Fomitopsis betulina by Grosse, Miriam, Wu, Shimin, Krings, Ulrich, Berger, Ralf G

“…During submerged cultivation, the edible basidiomycete Fomitopsis betulina (previously Piptoporus betulinus) developed a fruity odor, strongly reminding of…”
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The contribution of fungi to the global economy by Niego, Allen Grace T., Lambert, Christopher, Mortimer, Peter, Thongklang, Naritsada, Rapior, Sylvie, Grosse, Miriam, Schrey, Hedda, Charria-Girón, Esteban, Walker, Arttapon, Hyde, Kevin D., Stadler, Marc

“…Fungi provide ecological and environmental services to humans, as well as health and nutritional benefits, and are vital to numerous industries. Fermented food…”
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No resistance development against corallopyronin A in Wolbachia in C6/36 cell culture by Behrmann, Lara Vanessa, Lämmer, Christine, Schiefer, Andrea, Neufeld, Helene, Grosse, Miriam, Stadler, Marc, Bierbaum, Gabriele, Hoerauf, Achim, Pfarr, Kenneth

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(5E/Z,7E,9)-Decatrien-2-ones, Pineapple-like Flavors from Fomitopsis betulinaStructure Elucidation and Sensorial Properties by Grosse, Miriam, Pendzialeck, Tim, Fohrer, Jörg, Berger, Ralf G, Krings, Ulrich

“…During the cultivation of the edible mushroom Fomitopsis betulina on agro-industrial side streams, a pleasant flavor strongly reminiscent of pineapple was…”
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Response of the sesquiterpene synthesis in submerged cultures of the Basidiomycete Tyromyces floriformis to the medium composition by Grosse, Miriam, Strauss, Elisa, Krings, Ulrich, Berger, Ralf G.

“…Tyromyces floriformis, a potent fungal sesquiterpene producer, was grown Cerrena unicolor, as a model organism in submerged culture to search for chemicals…”
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Formation of Decatrienones with a Pineapple-like Aroma from 1- 13 C-Acetate by Cell Cultures of the Birch Polypore, Fomitopsis betulina by Grosse, Miriam, Wu, Shimin, Krings, Ulrich, Berger, Ralf G

“…During submerged cultivation, the edible basidiomycete (previously ) developed a fruity odor, strongly reminding of pineapple. Olfactometric analysis showed…”
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Biogenesis of spiroketals by submerged cultured basidiomycete Trametes hirsuta by Grosse, Miriam, Heuser, Verena, Ersoy, Franziska, Berger, Ralf G., Krings, Ulrich

“…Volatile spiroketals are well-documented semiochemicals secreted by beetles and wasps for the intra- and interspecies communication. Its use in insect traps…”
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Funktionalisierung von Chlorotonilen: Dehalogenil als vielversprechende Leitverbindung für die in vivo‐Anwendung by Hofer, Walter, Deschner, Felix, Jézéquel, Gwenaëlle, Pessanha de Carvalho, Laìs, Abdel‐Wadood, Noran, Pätzold, Linda, Bernecker, Steffen, Morgenstern, Bernd, Kany, Andreas M., Große, Miriam, Stadler, Marc, Bischoff, Markus, Hirsch, Anna K. H., Held, Jana, Herrmann, Jennifer, Müller, Rolf

“…Die Naturstoffklasse der Chlorotonile besitzt eine exzellente Wirksamkeit gegenüber multiresistenten Gram‐positiven Bakterien und Plasmodium falciparum. Die…”
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Erratum for Balthazar et al., "A laboratory-based predictive pathway for the development of Neisseria gonorrhoea e high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase" by Balthazar, Jacqueline T, Golparian, Daniel, Unemo, Magnus, Read, Timothy D, Grosse, Miriam, Stadler, Marc, Pfarr, Kenneth, Schiefer, Andrea, Hoerauf, Achim, Edwards, Jennifer L, Vassylyev, Dmitry G, Shafer, William M

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Pharmacology and early ADMET data of corallopyronin A, a natural product with macrofilaricidal anti-wolbachial activity in filarial nematodes by Ehrens, Alexandra, Schiefer, Andrea, Krome, Anna K., Becker, Tim, Rox, Katharina, Neufeld, Helene, Aden, Tilman, Wagner, Karl G., Müller, Rolf, Grosse, Miriam, Stadler, Marc, König, Gabriele M., Kehraus, Stefan, Alt, Silke, Hesterkamp, Thomas, Hübner, Marc Peter, Pfarr, Kenneth, Hoerauf, Achim

“…Corallopyronin A (CorA), a natural product antibiotic of Corallococcus coralloides , inhibits the bacterial DNA-dependent RNA polymerase. It is active against…”
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