Search Results - "Grosse, Laura"

Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients by Baldeón R, Lucy, Weigelt, Karin, de Wit, Harm, Ozcan, Behiye, van Oudenaren, Adri, Sempértegui, Fernando, Sijbrands, Eric, Grosse, Laura, Freire, Wilma, Drexhage, Hemmo A, Leenen, Pieter J M

“…There is increasing evidence that chronic inflammation is an important determinant in insulin resistance and in the pathogenesis of type 2 diabetes (T2D)…”
Get full text

Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder by Grosse, Laura, Carvalho, Livia A, Wijkhuijs, Annemarie J.M, Bellingrath, Silja, Ruland, Tillmann, Ambrée, Oliver, Alferink, Judith, Ehring, Thomas, Drexhage, Hemmo A, Arolt, Volker

“…Abstract Increased inflammatory activation might only be present in a subgroup of depressed individuals in which immune processes are especially relevant to…”
Get full text

Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation by Baldeón R, Lucy, Weigelt, Karin, de Wit, Harm, Ozcan, Behiye, van Oudenaren, Adri, Sempértegui, Fernando, Sijbrands, Eric, Grosse, Laura, van Zonneveld, Anton-Jan, Drexhage, Hemmo A, Leenen, Pieter J M

“…To study the expression pattern of microRNAs and mRNAs related to inflammation in T2D monocytes. A microRNA finding study on monocytes of T2D patients and…”
Get full text

Anxiety disorders and post-traumatic stress disorder in patients with coronary heart disease by Beer, Katja, Kuhlmann, Stella Linnea, Tschorn, Mira, Arolt, Volker, Grosse, Laura, Haverkamp, Wilhelm, Waltenberger, Johannes, Strehle, Jens, Martus, Peter, Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Ströhle, Andreas

“…•Anxiety disorders were frequent in patients with coronary heart disease•12-month anxiety disorder prevalence was 11.2% for men and 24.8% for women•12-month…”
Get full text

Deficiencies of the T and natural killer cell system in major depressive disorder by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…Highlights • Lymphocyte subsets were analyzed in major depressive disorder (MDD) patients. • NK cells, Th-2 cells, and Th-17 cells were reduced in MDD…”
Get full text

Cytokine Levels in Major Depression Are Related to Childhood Trauma but Not to Recent Stressors by Grosse, Laura, Ambrée, Oliver, Jörgens, Silke, Jawahar, M.Catharine, Singhal, Gaurav, Stacey, David, Arolt, Volker, Baune, Bernhard T

“…Highlights • Stress over lifetime was studied for effects on cytokine levels in major depression. • Serum TNF-α and IL-6 levels were associated with childhood…”
Get full text

Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy by Grosse, Laura, Carvalho, Livia A., Birkenhager, Tom K., Hoogendijk, Witte J., Kushner, Steven A., Drexhage, Hemmo A., Bergink, Veerle

“…Rationale There is a substantial unmet need for biomarkers to predict treatment response in major depressive disorder (MDD). Evidence has converged on…”
Get full text

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder by Becking, Karlijn, Haarman, Bartholomeus C.M., Grosse, Laura, Nolen, Willem A., Claes, Stephan, Arolt, Volker, Schoevers, Robert A., Drexhage, Hemmo A.

“…Clinical differentiation between bipolar disorder (BD) and major depressive disorder (MDD) is difficult. Research has therefore focused on discriminatory…”
Get full text

Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J, Wijkhuijs, Annemarie M, Arolt, Volker, Drexhage, Hemmo A

“…In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a…”
Get full text

Activation and deactivation steps in the tryptophan breakdown pathway in major depressive disorder: A link to the monocyte inflammatory state of patients by Arteaga-Henriquez, Gara, Burger, Bianka, Weidinger, Elif, Grosse, Laura, Moll, Natalie, Schuetze, Gregor, Schwarz, Markus, Wijkhuijs, Annemarie, Op de Beeck, Gommaar, Berghmans, Raf, Versnel, Marjan A., Arolt, Volker, Müller, Norbert, Drexhage, Hemmo A.

“…It is unclear how the tryptophan (TRP) breakdown pathway relates to the activated inflammatory state of patients with major depressive disorder (MDD). We…”
Get full text

Molecular serum signature of treatment resistant depression by Ruland, Tillmann, Chan, Man K., Stocki, Pawel, Grosse, Laura, Rothermundt, Matthias, Cooper, Jason D., Arolt, Volker, Bahn, Sabine

“…Rationale A substantial number of patients suffering from major depressive disorder (MDD) do not respond to multiple trials of anti-depressants, develop a…”
Get full text

Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study by Brandt, Julia, Warnke, Katharina, Jörgens, Silke, Arolt, Volker, Beer, Katja, Domschke, Katharina, Haverkamp, Wilhelm, Kuhlmann, Stella L., Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Schwarte, Kathrin, Ströhle, Andreas, Tschorn, Mira, Waltenberger, Johannes, Grosse, Laura

“…Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a…”
Get full text

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression by Ambrée, Oliver, Bergink, Veerle, Grosse, Laura, Alferink, Judith, Drexhage, Hemmo A., Rothermundt, Matthias, Arolt, Volker, Birkenhäger, Tom K.

“…Background: There is an ongoing search for biomarkers in psychiatry, for example, as diagnostic tools or predictors of treatment response. The neurotrophic…”
Get full text

Association of 5-HTTLPR/rs25531 with depressive symptoms in patients with coronary heart disease: A prospective study by Warnke, Katharina, Brandt, Julia, Jörgens, Silke, Arolt, Volker, Beer, Katja, Domschke, Katharina, Haverkamp, Wilhelm, Kuhlmann, Stella L., Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Schwarte, Kathrin, Ströhle, Andreas, Tschorn, Mira, Waltenberger, Johannes, Grosse, Laura

“…5-HTTLPR/rs25531 is suspected to be involved in the pathogenesis of both coronary heart disease (CHD)1 and depression. We aimed to investigate the role of…”
Get full text

Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients: A prospective study by Kuhlmann, Stella L., Tschorn, Mira, Arolt, Volker, Beer, Katja, Brandt, Julia, Grosse, Laura, Haverkamp, Wilhelm, Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Waltenberger, Johannes, Warnke, Katharina, Hellweg, Rainer, Ströhle, Andreas

“…•Lower serum BDNF levels are associated with the persistence of depressive symptoms in CHD patients.•Incident depressive symptoms are not related to lower…”
Get full text

Altered B Cell Homeostasis in Patients with Major Depressive Disorder and Normalization of CD5 Surface Expression on Regulatory B Cells in Treatment Responders by Ahmetspahic, Diana, Schwarte, Kathrin, Ambrée, Oliver, Bürger, Christian, Falcone, Vladislava, Seiler, Katharina, Kooybaran, Mehrdad Rahbar, Grosse, Laura, Roos, Fernand, Scheffer, Julia, Jörgens, Silke, Koelkebeck, Katja, Dannlowski, Udo, Arolt, Volker, Scheu, Stefanie, Alferink, Judith

“…Pro-inflammatory activity and cell-mediated immune responses have been widely observed in patients with major depressive disorder (MDD). Besides their…”
Get full text

Serum brain-derived neurotrophic factor and depressive symptoms in coronary heart disease patients: Role of cognitive functions by Kuhlmann, Stella L, Tschorn, Mira, Arolt, Volker, Beer, Katja, Brandt, Julia, Grosse, Laura, Haverkamp, Wilhelm, Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Waltenberger, Johannes, Warnke, Katharina, Hellweg, Rainer, Ströhle, Andreas

Get full text

BDNF and stability of depressive symptoms in coronary heart disease (CHD) patients: A prospective study by Kuhlmann, Stella L, Tschorn, Mira, Arolt, Volker, Beer, Katja, Brandt, Julia, Grosse, Laura, Haverkamp, Wilhelm, Müller-Nordhorn, Jacqueline, Rieckmann, Nina, Waltenberger, Johannes, Warnke, Katharina, Hellweg, Rainer, Ströhle, Andreas

“…Highlights • Lower serum BDNF levels are associated with the persistence of depressive symptoms in CHD patients. • Incident depressive symptoms are not related…”
Get full text

Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D by Baldeón Rojas, Lucy, Weigelt, Karin, de Wit, Harm, Ozcan, Behiye, van Oudenaren, Adri, Sempértegui, Fernando, Sijbrands, Eric, Grosse, Laura, van Zonneveld, Anton-Jan, Drexhage, Hemmo A, Leenen, Pieter J M

“…Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with…”
Get full text

Inflammatory monocyte activation is associated with natural T regulatory cell deficiencies and co-occurs with cellular immune defects in major depressive disorder by Grosse, Laura, Hoogenboezem, Thomas, Ambrée, Oliver, Bellingrath, Silja, Jörgens, Silke, de Wit, Harm J., Wijkhuijs, Annemarie M., Arolt, Volker, Drexhage, Hemmo A.

Get full text