Search Results - "Grosse, Evelyn Ellis"

The Efficacy and Safety of Tigecycline for the Treatment of Complicated Intra-Abdominal Infections: Analysis of Pooled Clinical Trial Data by Babinchak, Timothy, Grosse, Evelyn Ellis, Dartois, Nathalie, Rose, Gilbert M., Loh, Evan

“…This pooled analysis includes 2 phase 3, double-blind trials designed to evaluate the safety and efficacy of tigecycline, versus that of imipenem-cilastatin,…”
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Fosfomycin for Injection (ZTI-01) Versus Piperacillin-tazobactam for the Treatment of Complicated Urinary Tract Infection Including Acute Pyelonephritis: ZEUS, A Phase 2/3 Randomized Trial by Kaye, Keith S, Rice, Louis B, Dane, Aaron L, Stus, Viktor, Sagan, Olexiy, Fedosiuk, Elena, Das, Anita F, Skarinsky, David, Eckburg, Paul B, Ellis-Grosse, Evelyn J

“…Abstract Background ZTI-01 (fosfomycin for injection) is an epoxide antibiotic with a differentiated mechanism of action (MOA) inhibiting an early step in…”
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Pharmacokinetic-Pharmacodynamic Considerations in the Design of Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia Studies: Look before You Leap by Ambrose, Paul G., Bhavnani, Sujata M., Grosse, Evelyn J. Ellis, Drusano, George L.

“…Our thesis is a simple one: although a drug can fail in an individual patient for many reasons, appropriately sized and conducted drug-development programs…”
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The Pharmacokinetic and Pharmacodynamic Profile of Tigecycline by Meagher, Alison K., Ambrose, Paul G., Grasela, Thaddeus H., Grosse, J. Ellis

“…Tigecycline, a first-in-class expanded-spectrum antimicrobial agent, has demonstrated efficacy in the treatment of complicated intra-abdominal and skin and…”
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Safety and Efficacy of Tigecycline in Treatment of Skin and Skin Structure Infections: Results of a Double-Blind Phase 3 Comparison Study with Vancomycin-Aztreonam by BREEDT, Johannes, TERAS, Jüri, GARDOVSKIS, Janis, MARITZ, Frans Jacobus, VAASNA, Tiit, ROSS, Douglas Patrick, GIOUD-PAQUET, Martine, DARTOIS, Nathalie, ELLIS-GROSSE, Evelyn J, LOH, Evan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Frequentist and Bayesian Pharmacometric-Based Approaches To Facilitate Critically Needed New Antibiotic Development: Overcoming Lies, Damn Lies, and Statistics by Ambrose, Paul G, Hammel, Jeffrey P, Bhavnani, Sujata M, Rubino, Christopher M, Ellis-Grosse, Evelyn J, Drusano, George L

“…Antimicrobial drug development has greatly diminished due to regulatory uncertainty about the magnitude of the antibiotic treatment effect. Herein we evaluate…”
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Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites by Guyader, Dominique, Patat, Alain, Ellis-Grosse, Evelyn J., Orczyk, Gayle P.

“…Water retention and dilutional hyponatremia, mainly attributable to an impairment of free water excretion and increased vasopressin activity, are…”
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Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae by Diep, John K, Sharma, Rajnikant, Ellis-Grosse, Evelyn J, Abboud, Cely S, Rao, Gauri G

“…ZTI-01 (fosfomycin for injection) is a broad-spectrum antibiotic with a novel mechanism of action and is currently under development in the United States for…”
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Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa by Papp-Wallace, Krisztina M, Zeiser, Elise T, Becka, Scott A, Park, Steven, Wilson, Brigid M, Winkler, Marisa L, D'Souza, Roshan, Singh, Indresh, Sutton, Granger, Fouts, Derrick E, Chen, Liang, Kreiswirth, Barry N, Ellis-Grosse, Evelyn J, Drusano, George L, Perlin, David S, Bonomo, Robert A

“…Previously, by targeting penicillin-binding protein 3, Pseudomonas-derived cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin,…”
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Exploration of the Pharmacokinetic-Pharmacodynamic Relationships for Fosfomycin Efficacy Using an In Vitro Infection Model by VanScoy, Brian D, McCauley, Jennifer, Ellis-Grosse, Evelyn J, Okusanya, Olanrewaju O, Bhavnani, Sujata M, Forrest, Alan, Ambrose, Paul G

“…Fosfomycin, a phosphonic class antibiotic with a broad spectrum of antibacterial activity, has been used outside the United States since the early 1970s for…”
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Pharmacodynamic and immunomodulatory effects of polymyxin B in combination with fosfomycin against KPC-2-producing Klebsiella pneumoniae by Sharma, Rajnikant, Garcia, Estefany, Diep, John K., Lee, Vince H., Minhaj, Faisal, Jermain, Brian, Ellis-Grosse, Evelyn J., Abboud, Cely S., Rao, Gauri G.

“…•Host immunity plays an important role in clearance of bacterial infection.•Immunomodulatory and pharmacodynamic effects of polymyxin B and fosfomycin as mono-…”
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Relationship between Fosfomycin Exposure and Amplification of Escherichia coli Subpopulations with Reduced Susceptibility in a Hollow-Fiber Infection Model by VanScoy, Brian, McCauley, Jennifer, Bhavnani, Sujata M, Ellis-Grosse, Evelyn J, Ambrose, Paul G

“…Understanding the relationship between antibiotic exposure and amplification of bacterial subpopulations with reduced drug susceptibility over time is…”
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Activity of fosfomycin when tested against US contemporary bacterial isolates by Flamm, Robert K., Rhomberg, Paul R., Watters, Amy A., Sweeney, Kim, Ellis-Grosse, Evelyn J., Shortridge, Dee

“…Fosfomycin and comparators were susceptibility tested against over 2200 contemporary clinical isolates from US medical centers. Fosfomycin was active against…”
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Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose by Rodvold, Keith A., Gotfried, Mark H., Cwik, Michael, Korth-Bradley, Joan M., Dukart, Gary, Ellis-Grosse, Evelyn J.

“…Objectives: The purpose of this study was to determine the tissue and corresponding serum concentration of tigecycline at selected time points in gall bladder,…”
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Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia by Drusano, George L, Corrado, Michael L, Girardi, Gino, Ellis-Grosse, Evelyn J, Wunderink, Richard G, Donnelly, Helen, Leeper, Kenneth V, Brown, Mona, Malek, Tasnova, Hite, Robert Duncan, Ferrari, Michelle, Djureinovic, Danijela, Kollef, Marin H, Mayfield, Lisa, Doyle, Ann, Chastre, Jean, Combes, Alain, Walsh, Thomas J, Dorizas, Krisztina, Alnuaimat, Hassan, Morgan, Brooks Edward, Rello, Jordi, Torre, Cristopher Alan Mazo, Jones, Ronald N, Flamm, Robert K, Woosley, Leah, Ambrose, Paul G, Bhavnani, Sujata, Rubino, Christopher M, Bulik, Catharine C, Louie, Arnold, Vicchiarelli, Michael, Berman, Colleen

“…Ventilator-associated bacterial pneumonia (VABP) is a difficult therapeutic problem. Considerable controversy exists regarding the optimal chemotherapy for…”
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Erratum for Drusano et al., "Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia" by Drusano, George L, Corrado, Michael L, Girardi, Gino, Ellis-Grosse, Evelyn J, Wunderink, Richard G, Donnelly, Helen, Leeper, Kenneth V, Brown, Mona, Malek, Tasnova, Hite, Robert Duncan, Ferrari, Michelle, Djureinovic, Danijela, Kollef, Marin H, Mayfield, Lisa, Doyle, Ann, Chastre, Jean, Combes, Alain, Walsh, Thomas J, Dorizas, Krisztina, Alnuaimat, Hassan, Morgan, Brooks Edward, Rello, Jordi, Mazo, Cristopher A, Jones, Ronald N, Flamm, Robert K, Woosley, Leah, Ambrose, Paul G, Bhavnani, Sujata, Rubino, Christopher M, Bulik, Catharine C, Louie, Arnold, Vicchiarelli, Michael, Berman, Colleen

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Pharmacokinetic/pharmacodynamic profile for tigecycline—a new glycylcycline antimicrobial agent by Meagher, Alison K., Ambrose, Paul G., Grasela, Thaddeus H., Ellis-Grosse, Evelyn J.

“…Tigecycline is a new first-in-class glycylcycline antimicrobial agent with expanded broad-spectrum activity against both Gram-negative and Gram-positive…”
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Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation by RUBINO, Christopher M, LEI MA, BHAVNANI, Sujata M, KORTH-BRADLEY, Joan, SPETH, John, ELLIS-GROSSE, Evelyn, RODVOLD, Keith R, AMBROSE, Paul G, DRUSANO, George L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Exposure–response analyses of tigecycline tolerability in healthy subjects by Passarell, Julie, Ludwig, Elizabeth, Liolios, Kathryn, Meagher, Alison K, Grasela, Thaddeus H, Babinchak, Timothy, Ellis-Grosse, Evelyn J

“…Abstract Tigecycline exposure (area under the concentration–time curve [AUC(0-∞) ] and maximum serum concentration [ Cmax ]) and first occurrence of nausea and…”
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Moving goalposts-regulatory oversight of antibacterial drugs by Brenner, Randall, Ellis-Grosse, Evelyn J, Echols, Roger

“…Is uncertainty concerning the regulation of antimicrobial drug trials stifling investment in infectious disease treatments? Here, experts from a large pharma…”
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