Search Results - "Grosschedl, R"

Establishment and maintenance of B cell identity by Grosschedl, Rudolf

“…B lymphocyte differentiation is dependent on an intricate interplay of transcription factors and signaling pathways to establish a lineage-specific program of…”
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Ebf1 controls early cell differentiation in the embryonic striatum by Garel, S, Marín, F, Grosschedl, R, Charnay, P

“…Ebf1/Olf-1 belongs to a small multigene family encoding closely related helix-loop-helix transcription factors, which have been proposed to play a role in…”
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Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1 by Galceran, J, Miyashita-Lin, E M, Devaney, E, Rubenstein, J L, Grosschedl, R

“…Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the expression pattern and…”
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Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions by Giese, K, Kingsley, C, Kirshner, J R, Grosschedl, R

“…In this study we examine the molecular basis for the synergistic regulation of the minimal TCR alpha enhancer by multiple proteins. We find that reconstitution…”
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Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development by Kratochwil, K, Dull, M, Farinas, I, Galceran, J, Grosschedl, R

“…Targeted inactivation of the murine gene encoding the transcription factor LEF-1 abrogates the formation of organs that depend on epithelial-mesenchymal tissue…”
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Rescue of a Wnt Mutation by an Activated Form of LEF-1: Regulation of Maintenance but not Initiation of Brachyury Expression by Galceran, J, Hsu, S C, Grosschedl, R

“…Members of the LEF-1/TCF family of transcription factors have been implicated in mediating a nuclear response to Wnt signals by association with β-catenin…”
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Wnt signaling in lymphopoiesis by Timm, A, Grosschedl, R

“…Wnt signaling elicits changes in gene expression and cell physiology through beta-catenin and LEF1/TCF proteins. The signal transduction pathway regulates many…”
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Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice by Galceran, J., Farinas, I., Depew, M. J., Clevers, H., Grosschedl, R.

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Matrix Attachment Region-Dependent Function of the Immunoglobulin μ Enhancer Involves Histone Acetylation at a Distance without Changes in Enhancer Occupancy by Fernández, Luis A., Winkler, Michael, Grosschedl, Rudolf

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LEF‐1 contains an activation domain that stimulates transcription only in a specific context of factor‐binding sites by Giese, K., Grosschedl, R.

“…Lymphoid enhancer factor 1 (LEF‐1) is a member of the high mobility group (HMG) family of proteins and participates in the regulation of the T cell receptor…”
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Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions by Forrester, W C, Fernández, L A, Grosschedl, R

“…The immunoglobulin intragenic mu enhancer region acts as a locus control region that mediates transcriptional activation over large distances in germ line…”
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DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1 by GIESE, K, AMSTERDAM, A, GROSSCHEDL, R

“…Lymphoid enhancer-binding factor 1 (LEF-1) is a pre-B and T lymphocyte-specific nuclear protein that participates in the regulation of the T-cell antigen…”
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Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression by HAGMAN, J, BELANGER, C, TRAVIS, A, TURCK, C. W, GROSSCHEDL, R

“…Early B-cell factor (EBF) was identified previously as a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the…”
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An Inhibitory Carboxyl-Terminal Domain in Ets-1 and Ets-2 Mediates Differential Binding of ETS Family Factors to Promoter Sequences of the mb-1 Gene by Hagman, James, Grosschedl, Rudolf

“…The mb-1 gene is expressed only during the early stages of B-lymphocyte differentiation. Here we show that the mb-1 proximal promoter region contains a…”
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EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains by Hagman, J., Gutch, M.J., Lin, H., Grosschedl, R.

“…Early B cell factor (EBF) was identified and cloned as a transcription factor expressed specifically in B lymphocytes and adipocytes. This protein was also…”
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Distinct DNA-Binding Properties of the High Mobility Group Domain of Murine and Human SRY Sex-Determining Factors by GIESE, K, PAGEL, J, GROSSCHEDL, R

“…The mammalian sex-determining gene SRY (sex-determining region on Y chromosome) encodes a member of the high mobility group (HMG) family of regulatory…”
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A novel lineage‐specific nuclear factor regulates mb‐1 gene transcription at the early stages of B cell differentiation by Hagman, J., Travis, A., Grosschedl, R.

“…The mb‐1 gene, which encodes a protein associated with membrane‐bound antibody, is expressed only at the early stages of B cell differentiation. To gain…”
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Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1) by Duan, D, Yue, Y, Zhou, W, Labed, B, Ritchie, T C, Grosschedl, R, Engelhardt, J F

“…Previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 (Lef1) gene is upregulated in submucosal gland progenitor cells…”
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Purification of early-B-cell factor and characterization of its DNA-binding specificity by TRAVIS, A, HAGMAN, J, HWANG, L, GROSSCHEDL, R

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Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences by TRAVIS, A, HAGMAN, J, GROSSCHEDL, R

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