Search Results - "Grossbard, Elliott"

An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis by Weinblatt, Michael E, Kavanaugh, Arthur, Genovese, Mark C, Musser, Theresa K, Grossbard, Elliott B, Magilavy, Daniel B

“…Spleen tyrosine kinase (Syk) is an important modulator of immune signaling. In this randomized trial involving patients with active rheumatoid arthritis, there…”
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An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three‐month randomized, placebo‐controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents by Genovese, Mark C., Kavanaugh, Arthur, Weinblatt, Michael E., Peterfy, Charles, DiCarlo, Julie, White, Michael L., O'Brien, Maryann, Grossbard, Elliott B., Magilavy, Daniel B.

“…Objective To assess the efficacy and safety of R788 (fostamatinib disodium), an inhibitor of spleen tyrosine kinase (Syk), in patients with active rheumatoid…”
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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation by Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S

“…Recent compelling evidence has lead to renewed interest in the role of antibodies and immune complexes in the pathogenesis of several autoimmune disorders,…”
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Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies by Baluom, Muhammad, Grossbard, Elliott B., Mant, Tim, Lau, David T. W.

“…Aim Fostamatinib (R788) is an orally dosed prodrug designed to deliver the active metabolite R940406 (R406), a spleen tyrosine kinase (SYK) inhibitor, for the…”
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Effects of Fostamatinib (R788), an Oral Spleen Tyrosine Kinase Inhibitor, on Health-related Quality of Life in Patients with Active Rheumatoid Arthritis: Analyses of Patient-reported Outcomes from a Randomized, Double-blind, Placebo-controlled Trial by WEINBLATT, Michael E, KAVANAUGH, Arthur, GENOVESE, Mark C, JONES, David A, MUSSER, Theresa K, GROSSBARD, Elliott B, MAGILAVY, Daniel B

“…To assess the influence of fostamatinib on patient-reported outcomes (PRO) in patients with active rheumatoid arthritis and an inadequate response to…”
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Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor by Pine, Polly R, Chang, Betty, Schoettler, Nathan, Banquerigo, Mona L, Wang, Su, Lau, Angela, Zhao, Feifei, Grossbard, Elliott B, Payan, Donald G, Brahn, Ernest

“…Abstract Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal…”
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Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation by SWEENY, David J, WEIQUN LI, CLOUGH, Jeffrey, BHAMIDIPATI, Somasekhar, SINGH, Rajinder, PARK, Gary, BALUOM, Muhammad, GROSSBARD, Elliott, LAU, David T.-W

“…The metabolism of the spleen tyrosine kinase inhibitor…”
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JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice by Chang, Betty Y, Zhao, Feifei, He, Xiaodong, Ren, Hong, Braselmann, Sylvia, Taylor, Vanessa, Wicks, Joan, Payan, Donald G, Grossbard, Elliott B, Pine, Polly R, Bullard, Daniel C

“…JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic cells and binds specifically to the common gamma chain of a subfamily of…”
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Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies by Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli

“…Background Fostamatinib (R788) is a spleen tyrosine kinase (SYK) inhibitor. The active metabolite of fostamatinib, R406, is primarily metabolized by CYP3A4…”
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Fostamatinib, a Syk-Kinase Inhibitor, Does Not Affect Methotrexate Pharmacokinetics in Patients With Rheumatoid Arthritis by Baluom, Muhammad, Samara, Emil, Grossbard, Elliott B., Lau, David T.-W.

“…Fostamatinib (R788) is being investigated as an add‐on therapy for the treatment of rheumatoid arthritis (RA) in patients with inadequate response to…”
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Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406 by Zhu, Yanhong, Herlaar, Ellen, Masuda, Esteban S., Burleson, Gary R., Nelson, Andrew J., Grossbard, Elliott B., Clemens, George R.

“…Spleen tyrosine kinase (Syk) is a novel pharmaceutical target for treatment of allergic, autoimmune, and neoplastic disorders. Previous studies have indicated…”
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An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment by Meltzer, Eli O., Berkowitz, Robert B., Grossbard, Elliott B.

“…R112 inhibits Syk kinase, a transducer of signaling through the Fcε receptor of mast cells, blocking mast cell responses to allergic stimuli. Examine the…”
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Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing by Clemens, George R., Schroeder, Raymond E., Magness, Steven H., Weaver, Elizabeth V., Lech, Joseph W., Taylor, Vanessa C., Masuda, Esteban S., Baluom, Muhammad, Grossbard, Elliott B.

“…BACKGROUND: Urogenital abnormalities are among the most common of all human birth defects. In developmental toxicity studies with the Syk kinase inhibitor…”
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Targeting Syk as a treatment for allergic and autoimmune disorders by Wong, Brian R, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S

“…Recent advances in our understanding of allergic and autoimmune disorders have begun to translate into novel, effective and safe medicines for these common…”
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An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis by WEINBLATT, Michael E, KAVANAUGH, Arthur, GENOVESE, Mark C, MUSSER, Theresa K, GROSSBARD, Elliott B, MAGILAVY, Daniel B

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An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus by Bahjat, Frances Rena, Pine, Polly R., Reitsma, Andrea, Cassafer, Gail, Baluom, Muhammad, Grillo, Sunny, Chang, Betty, Zhao, Fei Fei, Payan, Donald G., Grossbard, Elliott B., Daikh, David I.

“…Objective To assess whether R788, an orally bioavailable small molecule inhibitor of spleen tyrosine kinase (Syk)–dependent signaling, could modulate disease…”
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Human Brain Natriuretic Peptide Reduces Blood Pressure in Normotensive and Acute Norepinephrine-Induced Hypertensive Rabbits by Clemens, L.Edward, Almirez, Ramona G, Baudouin, Karine A, Grossbard, Elliott B, Protter, Andrew A

“…Human brain natriuretic peptide (hBNP) is a cardiac-derived peptide hormone with potent hemodynamic and renal effects in dogs, monkeys, and humans, but not in…”
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A perfluorochemical emulsion for prehospital resuscitation of experimental hemorrhagic shock: a prospective, randomized, controlled study by Goodin, T H, Grossbard, E B, Kaufman, R J, Richard, T J, Kolata, R J, Allen, J S, Layton, T E

“…To evaluate the efficacy of a novel, oxygen-transporting perfluorochemical emulsion as a prehospital therapy, using a canine hemorrhagic shock model based on…”
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Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen by McLaughlin, John, Markovtsov, Vadim, Li, Hui, Wong, Steve, Gelman, Marina, Zhu, Yanhong, Franci, Christian, Lang, D. Wayne, Pali, Erlina, Lasaga, Joe, Low, Caroline, Zhao, Feifei, Chang, Betty, Gururaja, Tarikere L, Xu, Weiduan, Baluom, Muhammad, Sweeny, David, Carroll, David, Sran, Arvinder, Thota, Sambaiah, Parmer, Manjeet, Romane, Angela, Clemens, George, Grossbard, Elliott, Qu, Kunbin, Jenkins, Yonchu, Kinoshita, Taisei, Taylor, Vanessa, Holland, Sacha J, Argade, Ankush, Singh, Rajinder, Pine, Polly, Payan, Donald G, Hitoshi, Yasumichi

“…Purpose Aurora kinases play a key role in mitotic progression. Over-expression of Aurora kinases is found in several human cancers and correlated with…”
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Pharmacokinetics and biological actions of subcutaneously administered human brain natriuretic peptide by Clemens, L E, Almirez, R G, Baudouin, K A, Mischak, R P, Grossbard, E B, Protter, A A

“…Human brain natriuretic peptide (hBNP) has demonstrated favorable hemodynamic effects in patients with congestive heart failure; however, the peptidic nature…”
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