Search Results - "Gross Margolis, Kara"
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Novel aspects of enteric serotonergic signaling in health and brain-gut disease
Published in American journal of physiology: Gastrointestinal and liver physiology (01-01-2020)“…Gastrointestinal (GI) comorbidities are common in individuals with mood and behavioral dysfunction. Similarly, patients with GI problems more commonly suffer…”
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Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder
Published in Frontiers in psychiatry (25-07-2019)“…Many individuals with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but their etiology is currently unknown. Dietary…”
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Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance
Published in Handbook of experimental pharmacology (01-01-2017)“…Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body's…”
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The gut, its microbiome, and the brain: connections and communications
Published in The Journal of clinical investigation (15-09-2021)“…Modern research on gastrointestinal behavior has revealed it to be a highly complex bidirectional process in which the gut sends signals to the brain, via…”
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Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Published in Cell (17-07-2014)“…Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions;…”
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Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children’s Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up
Published in Pediatric critical care medicine (01-03-2021)“…The disease caused by severe acute respiratory syndrome coronavirus 2, known as coronavirus disease 2019, has resulted in a global pandemic. Reports are…”
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Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects
Published in Gut (01-04-2022)“…The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and…”
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Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention
Published in Current pharmaceutical design (01-01-2019)“…Genetics is a major etiological contributor to autism spectrum disorder (ASD). Environmental factors, however, also appear to contribute. ASD pathophysiology…”
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Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Published in Cell (28-08-2014)Get full text
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Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis
Published in American journal of physiology: Gastrointestinal and liver physiology (01-11-2017)“…Necrotizing enterocolitis (NEC), a gastrointestinal inflammatory disease of unknown etiology that may also affect the liver, causes a great deal of morbidity…”
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Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies
Published in Frontiers in neuroscience (07-03-2024)“…Critical phases of neurodevelopment and gut microbiota diversification occur in early life and both processes are impacted by genetic and environmental…”
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Associations between cytokines, endocrine stress response, and gastrointestinal symptoms in autism spectrum disorder
Published in Brain, behavior, and immunity (01-11-2016)“…Highlights • Lower gastrointestinal tract symptoms relate to cortisol response to stress in ASD. • Lower gastrointestinal tract symptoms not related to…”
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Enteric Neuronal Density Contributes to the Severity of Intestinal Inflammation
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2011)“…Background & Aims Enteric neurons have been reported to be increased in inflamed regions of the bowel in patients with inflammatory bowel disease or intestinal…”
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Serotonin Has a Critical Role in the Pathogenesis of Experimental Colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-11-2009)Get full text
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Phenotypic Heterogeneity of Neutropenia and Gastrointestinal Illness Associated with G6PC3 Founder Mutation
Published in Journal of pediatric hematology/oncology (01-10-2016)“…Severe congenital neutropenia type IV (SCN IV) is a syndrome of severe neutropenia, cardiac and urogenital defects, prominent superficial veins, facial…”
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Role of Substance P in the Regulation of Glucose Metabolism via Insulin Signaling-Associated Pathways
Published in Endocrinology (Philadelphia) (01-12-2011)“…Substance P (SP), encoded by the tachykinin 1 (Tac1) gene, is the most potent tachykinin ligand for the high-affinity neurokinin-1 receptor (NK-1R). We…”
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Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Published in Pharmacological research (01-06-2018)“…Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of…”
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The Microbiome in Early Biomarker Discovery for Neurodevelopmental Disorders: A Novel Research Roadmap?
Published in Gastroenterology (New York, N.Y. 1943) (01-09-2024)Get full text
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Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Published in Pharmacological research (01-02-2019)“…Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of…”
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Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
Published in Pharmacological research (01-02-2019)“…Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of…”
Get full text
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