Search Results - "Gross, Richard W."

The foundations and development of lipidomics by Han, Xianlin, Gross, Richard W.

“…For over a century, the importance of lipid metabolism in biology was recognized but difficult to mechanistically understand due to the lack of sensitive and…”
Get full text

Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy by Viader, Andreu, Sasaki, Yo, Kim, Sungsu, Strickland, Amy, Workman, Cayce S., Yang, Kui, Gross, Richard W., Milbrandt, Jeffrey

“…Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has been devoted to examining the role played by neuronal/axonal…”
Get full text

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation by Li, Wenjun, Feng, Guoshuai, Gauthier, Jason M, Lokshina, Inessa, Higashikubo, Ryuji, Evans, Sarah, Liu, Xinping, Hassan, Adil, Tanaka, Satona, Cicka, Markus, Hsiao, Hsi-Min, Ruiz-Perez, Daniel, Bredemeyer, Andrea, Gross, Richard W, Mann, Douglas L, Tyurina, Yulia Y, Gelman, Andrew E, Kagan, Valerian E, Linkermann, Andreas, Lavine, Kory J, Kreisel, Daniel

“…Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate…”
Get full text

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation by Yao, Cong-Hui, Liu, Gao-Yuan, Wang, Rencheng, Moon, Sung Ho, Gross, Richard W, Patti, Gary J

“…It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by…”
Get full text

Automated Lipid Identification and Quantification by Multidimensional Mass Spectrometry-Based Shotgun Lipidomics by Yang, Kui, Cheng, Hua, Gross, Richard W, Han, Xianlin

“…This article presents the strategies underlying the automated identification and quantification of individual lipid molecular species through array analysis of…”
Get full text

Identification and Quantitation of Fatty Acid Double Bond Positional Isomers: A Shotgun Lipidomics Approach Using Charge-Switch Derivatization by Yang, Kui, Dilthey, Beverly Gibson, Gross, Richard W.

“…The specific locations of double bonds in mammalian lipids have profound effects on biological membrane structure, dynamics and lipid second messenger…”
Get full text

Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts by Yao, Cong-Hui, Fowle-Grider, Ronald, Mahieu, Nathanial G, Liu, Gao-Yuan, Chen, Ying-Jr, Wang, Rencheng, Singh, Manmilan, Potter, Gregory S, Gross, Richard W, Schaefer, Jacob, Johnson, Stephen L, Patti, Gary J

“…Cellular proliferation requires the formation of new membranes. It is often assumed that the lipids needed for these membranes are synthesized mostly de novo…”
Get more information

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance by Beirowski, Bogdan, Babetto, Elisabetta, Golden, Judith P, Chen, Ying-Jr, Yang, Kui, Gross, Richard W, Patti, Gary J, Milbrandt, Jeffrey

“…Axonal maintenance is known to rely, in part, on non-cell-autonomous support from myelinating glia, but the mechanisms are still unclear. In this study, the…”
Get full text

Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples by Han, Xianlin, Gross, Richard W.

“…Lipidomics, after genomics and proteomics, is a newly and rapidly expanding research field that studies cellular lipidomes and the organizational hierarchy of…”
Get full text

The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization by Malley, Konstantin R., Koroleva, Olga, Miller, Ian, Sanishvili, Ruslan, Jenkins, Christopher M., Gross, Richard W., Korolev, Sergey

“…Calcium-independent phospholipase A 2 β (iPLA 2 β) regulates important physiological processes including inflammation, calcium homeostasis and apoptosis. It is…”
Get full text

High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress by Moon, Sung Ho, Dilthey, Beverly Gibson, Liu, Xinping, Guan, Shaoping, Sims, Harold F., Gross, Richard W.

“…High-fat (HF) diet–induced obesity precipitates multiple metabolic disorders including insulin resistance, glucose intolerance, oxidative stress, and…”
Get full text

Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A2 and mitochondrial respiration by Moon, Sung Ho, Liu, Xinping, Jenkins, Christopher M., Dilthey, Beverly Gibson, Patti, Gary J., Gross, Richard W.

“…Mitochondrial fatty acid oxidation serves as an essential process for cellular survival, differentiation, proliferation, and energy metabolism. Numerous…”
Get full text

Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways by Liu, Xinping, Moon, Sung Ho, Jenkins, Christopher M, Sims, Harold F, Gross, Richard W

“…Eicosanoid lipids play important roles in cellular signaling as second messengers in inflammation, immune response, vascular tone, and the CNS. Biosynthesis of…”
Get more information

Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics by Han, Xianlin, Gross, Richard W

“…Lipidomics is a rapidly expanding research field in which multiple techniques are utilized to quantitate the hundreds of chemically distinct lipids in cells…”
Get full text

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes[S] by Harris, Charles A., Haas, Joel T., Streeper, Ryan S., Stone, Scot J., Kumari, Manju, Yang, Kui, Han, Xianlin, Brownell, Nicholas, Gross, Richard W., Zechner, Rudolf, Farese, Jr. Robert V.

“…The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been…”
Get full text

CD36 Is Important for Fatty Acid and Cholesterol Uptake by the Proximal but Not Distal Intestine by Nassir, Fatiha, Wilson, Brody, Han, Xianlin, Gross, Richard W., Abumrad, Nada A.

“…CD36, a membrane protein that facilitates fatty acid uptake, is highly expressed in the intestine on the luminal surface of enterocytes. Cd36 null (Cd36–/–)…”
Get full text

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome[S] by Basantani, Mahesh K., Sitnick, Mitch T., Cai, Lingzhi, Brenner, Daniel S., Gardner, Noah P., Li, John Zhong, Schoiswohl, Gabriele, Yang, Kui, Kumari, Manju, Gross, Richard W., Zechner, Rudolf, Kershaw, Erin E.

“…PNPLA3 (adiponutrin, calcium-independent phos­pholipase A2 epsilon [iPLA2∊]) is an adipose-enriched, nutritionally regulated protein that belongs to the…”
Get full text

Alterations in Myocardial Cardiolipin Content and Composition Occur at the Very Earliest Stages of Diabetes:  A Shotgun Lipidomics Study by Han, Xianlin, Yang, Jingyue, Yang, Kui, Zhao, Zhongdan, Abendschein, Dana R, Gross, Richard W

“…Recently, we have identified the dramatic depletion of cardiolipin (CL) in diabetic myocardium 6 weeks after streptozotocin (STZ) injection that was…”
Get full text

Identification and Quantitation of Unsaturated Fatty Acid Isomers by Electrospray Ionization Tandem Mass Spectrometry: A Shotgun Lipidomics Approach by Yang, Kui, Zhao, Zhongdan, Gross, Richard W, Han, Xianlin

“…Identification and quantification of unsaturated fatty acid (FA) isomers in a biological system are significant in the study of lipid metabolism and…”
Get full text

Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2–15-HETE lysophospholipids by Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Guan, Shaoping, Gross, Richard W.

“…Recently, oxidized phospholipid species have emerged as important signaling lipids in activated immune cells and platelets. The canonical pathway for the…”
Get full text