Search Results - "Gross, Eric R."

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities by Chen, Che-Hong, Ferreira, Julio Cesar Batista, Gross, Eric R, Mochly-Rosen, Daria

“…A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a subject of recent interest, as its role in detoxifying aldehydes that…”
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Peptidomimetic therapeutics: scientific approaches and opportunities by Qvit, Nir, Rubin, Samuel J.S., Urban, Travis J., Mochly-Rosen, Daria, Gross, Eric R.

“…•Naturally occurring peptides are important resources in order to develop pharmaceutical lead compounds.•Natural peptides are often limited by poor stability…”
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Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia–reperfusion Injury in Rodents by Lu, Yao, Piplani, Honit, McAllister, Stacy L, Hurt, Carl M, Gross, Eric R

“…BACKGROUND:Recent evidence suggests that cross talk exists between cellular pathways important for pain signaling and ischemia–reperfusion injury. Here, the…”
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A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents by He, Shufang, Zambelli, Vanessa O, Sinharoy, Pritam, Brabenec, Laura, Bian, Yang, Rwere, Freeborn, Hell, Rafaela Cr, Stein Neto, Beatriz, Hung, Barbara, Yu, Xuan, Zhao, Meng, Luo, Zhaofei, Wu, Chao, Xu, Lijun, Svensson, Katrin J, McAllister, Stacy L, Stary, Creed M, Wagner, Nana-Maria, Zhang, Ye, Gross, Eric R

“…Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain…”
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E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme by Yu, Xuan, Zeng, Xiaocong, Xiao, Feng, Chen, Ri, Sinharoy, Pritam, Gross, Eric R.

“…E-cigarette aerosol containing aldehydes, including acetaldehyde, are metabolized by the enzyme aldehyde dehydrogenase 2 (ALDH2). However, little is known how…”
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Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge by Rwere, Freeborn, White, Joseph R, Hell, Rafaela C R, Yu, Xuan, Zeng, Xiaocong, McNeil, Leslie, Zhou, Kevin N, Angst, Martin S, Chen, Che-Hong, Mochly-Rosen, Daria, Gross, Eric R

“…Aldehyde dehydrogenase 2 (ALDH2) is critical for alcohol metabolism by converting acetaldehyde to acetic acid. In East Asian descendants, an inactive genetic…”
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TRP Channels as Sensors of Aldehyde and Oxidative Stress by Hellenthal, Katharina E M, Brabenec, Laura, Gross, Eric R, Wagner, Nana-Maria

“…The transient receptor potential (TRP) cation channel superfamily comprises more than 50 channels that play crucial roles in physiological processes. TRP…”
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Diabetes Abolishes Morphine-Induced Cardioprotection via Multiple Pathways Upstream of Glycogen Synthase Kinase-3β by GROSS, Eric R, HSU, Anna K, GROSS, Garrett J

“…Diabetes Abolishes Morphine-Induced Cardioprotection via Multiple Pathways Upstream of Glycogen Synthase Kinase-3β Eric R. Gross , Anna K. Hsu and Garrett J…”
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E-Cigarettes and Cardiopulmonary Health by Tarran, Robert, Barr, R Graham, Benowitz, Neal L, Bhatnagar, Aruni, Chu, Hong W, Dalton, Pamela, Doerschuk, Claire M, Drummond, M Bradley, Gold, Diane R, Goniewicz, Maciej L, Gross, Eric R, Hansel, Nadia N, Hopke, Philip K, Kloner, Robert A, Mikheev, Vladimir B, Neczypor, Evan W, Pinkerton, Kent E, Postow, Lisa, Rahman, Irfan, Samet, Jonathan M, Salathe, Matthias, Stoney, Catherine M, Tsao, Philip S, Widome, Rachel, Xia, Tian, Xiao, DaLiao, Wold, Loren E

“…E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids,…”
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Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury by Hurt, Carl M., Lu, Yao, M. Stary, Creed, Piplani, Honit, Small, Bryce A., Urban, Travis J., Qvit, Nir, Gross, Garrett J., Mochly‐Rosen, Daria, Gross, Eric R.

“…Background The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the…”
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Precision medicine considerations for the management of heart disease and stroke in East Asians by Goodnough, Candida, Gross, Eric

“…Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point…”
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Activation of kappa-opioid receptors at reperfusion affords cardioprotection in both rat and mouse hearts by Peart, Jason N., Gross, Eric R., Reichelt, Melissa E., Hsu, Anna, Headrick, John P., Gross, Garrett J.

“…The temporal properties of kappa-opioid receptor (κ-OR) mediated cardioprotection are less well characterised than delta-opioid receptor (δ-OR) responses. This…”
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Opioid-induced preconditioning: Recent advances and future perspectives by Peart, Jason N., Gross, Eric R., Gross, Garrett J.

“…Opioids, named by Acheson [Martin, W.R., 1967. Opioid antagonists.Pharmacol Rev. 19, 463–521] for compounds with morphine-like actions despite chemically…”
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Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion by Gross, Eric R, Hsu, Anna K, Gross, Garrett J

“…Previous studies in our laboratory suggest that an acute inhibition of glycogen synthase kinase 3 (GSK3) by SB-216763 (SB21) is cardioprotective when…”
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Fixing a Broken Heart Opens the Door to Developing KATP Channel Agonists as Pain Relievers by Zambelli, Vanessa O, Gross, Eric R

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Exosomes as perioperative therapeutics to limit organ injury by Owen, Andrew, Stary, Creed M, Gross, Eric R

“…Perioperative organ injury is a frequent and major complication for the ∼240 million people undergoing surgery worldwide annually. Ischaemic preconditioning is…”
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Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium by Rwere, Freeborn, Yu, Xuan, Chen, Che-Hong, Gross, Eric R

“…The discovery of aldehydes dates back to 1774 when Carl Wilhelm Scheele synthesized acetaldehyde [...]…”
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Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors by McAllister, Stacy L., Sinharoy, Pritam, Vasu, Megana, Gross, Eric R.

“…Endometriosis affects ∼176 million women worldwide, yet on average, women experience pain ∼10 years from symptom onset before being properly diagnosed…”
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Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder by Heymann, Helen M., Gardner, Adriana M., Gross, Eric R.

“…Alcohol use disorder (AUD) screening frequently involves questionnaires complemented by laboratory work to monitor alcohol use and/or evaluate AUD-associated…”
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Topical analgesic BENGAY® reduces myocardial infarct size in rodents by Goodnough, Candida L, Wu, Yun, Gross, Eric R

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