Search Results - "Gross, Elizabeth A"

Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein by Schroeter, Jeffry D., Kimbell, Julia S., Gross, Elizabeth A., Willson, Gabrielle A., Dorman, David C., Tan, Yu-Mei, Clewell, Harvey J.

“…Acrolein is a highly soluble and reactive aldehyde and is a potent upper-respiratory-tract irritant. Acrolein-induced nasal lesions in rodents include…”
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Direct Olfactory Transport of Inhaled Manganese (54MnCl2) to the Rat Brain: Toxicokinetic Investigations in a Unilateral Nasal Occlusion Model by Brenneman, Karrie A., Wong, Brian A., Buccellato, Matthew A., Costa, Elisabeth R., Gross, Elizabeth A., Dorman, David C.

“…Inhalation exposure of humans to high concentrations of manganese (Mn) is associated with elevated Mn levels in the basal ganglia and an extrapyramidal…”
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Information Literacy in Context: Skill Development in Pre- and In-Service School Librarians by Adair, Heather F., Crane, Ashley B., Gross, Elizabeth A.

“…Information literacy is a crucial topic in the library science profession. The information needs and perceptions of the information literacy of preservice and…”
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Sub-chronic inhalation of high concentrations of manganese sulfate induces lower airway pathology in rhesus monkeys by Dorman, David C, Struve, Melanie F, Gross, Elizabeth A, Wong, Brian A, Howroyd, Paul C

“…Neurotoxicity and pulmonary dysfunction are well-recognized problems associated with prolonged human exposure to high concentrations of airborne manganese…”
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Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague-Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure by DORMAN, David C, STRUVE, Melanie F, GROSS, Elizabeth A, BRENNEMAN, Karrie A

“…The goal of this study was to characterize the toxicity of hydrogen sulfide (H2S), including nasal and pulmonary effects, in adult male and female Fischer-344…”
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Olfactory Neuron Loss in Adult Male CD Rats Following Subchronic Inhalation Exposure to Hydrogen Sulfide by Brenneman, Karrie A., Arden James, R., Gross, Elizabeth A., Dorman, David C.

“…Dysosmia and anosmia are reported to occur following human exposure to hydrogen sulfide (H2S) gas. The clinical association between H2S exposure and olfactory…”
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Olfactory Mucosal Necrosis in Male CD Rats Following Acute Inhalation Exposure to Hydrogen Sulfide: Reversibility and the Possible Role of Regional Metabolism by Brenneman, Karrie A., Meleason, David F., Sar, Madhabananda, Marshall, Marianne W., James, R. Arden, Gross, Elizabeth A., Martin, Joseph T., Dorman, David C.

“…Hydrogen sulfide (H 2S) is a potent inhibitor of cytochrome oxidase (CO) and is associated with dysosmia and anosmia in humans and nasal lesions in exposed…”
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Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice by Mery, S, Gross, E A, Joyner, D R, Godo, M, Morgan, K T

“…Knowledge of patterns of lesion distribution can provide insight into the relative roles played by regional tissue dose and local tissue susceptibility in…”
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Nasal epithelial lesions in F344 rats following a 90-day inhalation exposure to naphthalene by Dodd, Darol E., Wong, Brian A., Gross, Elizabeth A., Miller, Rodney A.

“…Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial…”
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Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans by Price, Paul S., Conolly, Rory B., Chaisson, Christine F., Gross, Elizabeth A., Young, John S., Mathis, Eric T., Tedder, Douglas R.

“…Modeling interindividual variation in internal doses in humans using PBPK models requires data on the variation in physiological parameters across the…”
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The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis by Miller, Frederick J., Kimbell, Julia S., Preston, R. Julian, Overton, John H., Gross, Elizabeth A., Conolly, Rory B.

“…Clonal growth modeling of carcinogenesis requires data on the number of cells at risk of becoming cancerous. We synthesized literature data to estimate the…”
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Respiratory Tract Responses in Male Rats Following Subchronic Acrolein Inhalation by Dorman, David C., Struve, Melanie F., Wong, Brian A., Marshall, Marianne W., Gross, Elizabeth A., Willson, Gabrielle A.

“…The goal of this study was to characterize the respiratory tract toxicity of acrolein, including nasal and pulmonary effects, in adult male F344 rats. Animals…”
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p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene by Meng, Fanxue, Wang, Yiying, Myers, Meagan B., Wong, Brian A., Gross, Elizabeth A., Clewell, Harvey J., Dodd, Darol E., Parsons, Barbara L.

“…A 2-year rat tumor bioassay testing whole body exposure to naphthalene (NA) vapor found a significant increase in nasal respiratory epithelial adenomas in male…”
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Nasal Olfactory Epithelial Lesions in F344 and SD Rats Following 1- and 5-Day Inhalation Exposure to Naphthalene Vapor by Dodd, Darol E., Gross, Elizabeth A., Miller, Rodney A., Wong, Brian A.

“…The exposure–response relationship and threshold for nasal epithelial effects of naphthalene (NP) vapor in F344 and SD rats were investigated in 1-day (6…”
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Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation by Dorman, David C., Struve, Melanie F., Wong, Brian A., Gross, Elizabeth A., Parkinson, Carl, Willson, Gabrielle A., Tan, Yu-Mei, Campbell, Jerry L., Teeguarden, Justin G., Clewell, Harvey J., Andersen, Melvin E.

“…Acetaldehyde inhalation induces neoplastic and nonneoplastic responses in the rodent nasal cavity. This experiment further characterizes the dose-response…”
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Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells by MONTICELLO, T. M, SWENBERG, J. A, GROSS, E. A, LEININGER, J. R, KIMBELL, J. S, SEILKOP, S, STARR, T. B, GIBSON, J. E, MORGAN, K. T

“…Formaldehyde induces nonlinear, concentration-related increases in nasal epithelial cell proliferation and squamous cell carcinomas (SCC) in rats. A…”
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p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats by RECIO, L, SISK, S, PLUTA, L, BERMUDEZ, E, GROSS, E. A, ZHUCHU CHEN, MORGAN, K, WALKER, C

“…Formaldehyde induces squamous cell carcinomas in the nasal passages of rats following chronic inhalation exposure at concentrations of > or = 10 ppm. We have…”
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Psychological Factors in the Determination of Suicide in Self-Inflicted Gunshot Head Wounds by Weinberger, LE, Sreenivasan, S, Gross, EA, Markowitz, E, Gross, BH

“…Self-inflicted contact gunshot wounds to the head have usually been considered presumptive of suicide. This study evaluates whether sufficient psychological…”
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Pathology and cell proliferation induced by intra-nasal instillation of aldehydes in the rat: comparison of glutaraldehyde and formaldehyde by St Clair, M B, Gross, E A, Morgan, K T

“…The relative toxicities of formaldehyde and glutaraldehyde to the rat nasal epithelium were determined following intra-nasal instillation of aqueous solutions…”
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Evaluation of the genotoxic potential of glutaraldehyde by St Clair, M B, Bermudez, E, Gross, E A, Butterworth, B E, Recio, L

“…The cytotoxic and genotoxic effects of glutaraldehyde were studied in vitro in the human TK6 lymphoblast cell line and in primary cultures of rat hepatocytes…”
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