Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus

Highlights • CA1 pyramidal neurons’ membrane properties are altered during oxygen-glucose deprivation leading to increased excitability. • Excitatory synaptic transmission is increased during both oxygen-glucose deprivation and reoxygenation. • Excitatory postsynaptic current amplitude is unchanged...

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Bibliographic Details
Published in:	Neuroscience Vol. 310; pp. 279 - 289
Main Authors:	Zanelli, S.A, Rajasekaran, K, Grosenbaugh, D.K, Kapur, J
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 03-12-2015
Subjects:	Action Potentials Animals Animals, Newborn CA1 Region, Hippocampal - physiopathology electrophysiology excitability excitatory postsynaptic current Excitatory Postsynaptic Potentials Hypoxia-Ischemia, Brain - physiopathology Mice Mice, Inbred C57BL Miniature Postsynaptic Potentials neonatal brain Neurology Pyramidal Cells - physiology seizure neonatal brain seizure resting membrane potential hyperpolarization activated current spontaneous excitatory postsynaptic currents oxygen-glucose deprivation I h Vm TTX miniature excitatory post-synaptic currents excitatory postsynaptic current hyperpolarization-activated cyclic-nucleotide-gated EPSCs sEPSCs action potential OGD AP K–S HCN excitability Kolmogorov–Smirnov RMP electrophysiology Rin membrane potential mEPSCs excitatory post-synaptic currents tetrodotoxin input resistance Ih
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Summary:	Highlights • CA1 pyramidal neurons’ membrane properties are altered during oxygen-glucose deprivation leading to increased excitability. • Excitatory synaptic transmission is increased during both oxygen-glucose deprivation and reoxygenation. • Excitatory postsynaptic current amplitude is unchanged indicating increased release and presynaptic mechanisms. • These mechanisms may represent key steps in the progression from ischemic insult to acute seizure in the neonatal brain.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 jk8t@virginia.edu karthik.rajasekaran@utsouthwestern.edu dg5kd@virginia.edu
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.09.046