Search Results - "Groschner, Lukas N."

A biophysical account of multiplication by a single neuron by Groschner, Lukas N., Malis, Jonatan G., Zuidinga, Birte, Borst, Alexander

“…Nonlinear, multiplication-like operations carried out by individual nerve cells greatly enhance the computational power of a neural system 1 – 3 , but our…”
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An open platform for visual stimulation of insects by Prech, Stefan, Groschner, Lukas N, Borst, Alexander

“…To study how the nervous system processes visual information, experimenters must record neural activity while delivering visual stimuli in a controlled…”
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Response competition between neurons and antineurons in the mushroom body by Vrontou, Eleftheria, Groschner, Lukas N., Szydlowski, Susanne, Brain, Ruth, Krebbers, Alina, Miesenböck, Gero

“…The mushroom bodies of Drosophila contain circuitry compatible with race models of perceptual choice. When flies discriminate odor intensity differences,…”
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Dendritic Integration of Sensory Evidence in Perceptual Decision-Making by Groschner, Lukas N., Chan Wah Hak, Laura, Bogacz, Rafal, DasGupta, Shamik, Miesenböck, Gero

“…Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal…”
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Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes by Zhang, Quan, Ramracheya, Reshma, Lahmann, Carolina, Tarasov, Andrei, Bengtsson, Martin, Braha, Orit, Braun, Matthias, Brereton, Melissa, Collins, Stephan, Galvanovskis, Juris, Gonzalez, Alejandro, Groschner, Lukas N., Rorsman, Nils J.G., Salehi, Albert, Travers, Mary E., Walker, Jonathan N., Gloyn, Anna L., Gribble, Fiona, Johnson, Paul R.V., Reimann, Frank, Ashcroft, Frances M., Rorsman, Patrik

“…Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose,…”
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Endothelial mitochondria—less respiration, more integration by Groschner, Lukas N., Waldeck-Weiermair, Markus, Malli, Roland, Graier, Wolfgang F.

“…Lining the inner surface of the circulatory system, the vascular endothelium accomplishes a vast variety of specialized functions. Even slight alterations of…”
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ATP increases within the lumen of the endoplasmic reticulum upon intracellular Ca2+ release by Vishnu, Neelanjan, Jadoon Khan, Muhammad, Karsten, Felix, Groschner, Lukas N, Waldeck-Weiermair, Markus, Rost, Rene, Hallström, Seth, Imamura, Hiromi, Graier, Wolfgang F, Malli, Roland

“…Multiple functions of the endoplasmic reticulum (ER) essentially depend on ATP within this organelle. However, little is known about ER ATP dynamics and the…”
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How Flies See Motion by Borst, Alexander, Groschner, Lukas N

“…How neurons detect the direction of motion is a prime example of neural computation: Motion vision is found in the visual systems of virtually all sighted…”
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Mapping the function of neuronal ion channels in model and experiment by Podlaski, William F, Seeholzer, Alexander, Groschner, Lukas N, Miesenböck, Gero, Ranjan, Rajnish, Vogels, Tim P

“…Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of…”
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Mechanisms of Sensory Discrimination: Insights from Drosophila Olfaction by Groschner, Lukas N, Miesenböck, Gero

“…All an animal can do to infer the state of its environment is to observe the sensory-evoked activity of its own neurons. These inferences about the presence,…”
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Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells by Alam, Muhammad Rizwan, Groschner, Lukas N., Parichatikanond, Warisara, Kuo, Liang, Bondarenko, Alexander I., Rost, Rene, Waldeck-Weiermair, Markus, Malli, Roland, Graier, Wolfgang F.

“…In pancreatic β-cells, uptake of Ca2+ into mitochondria facilitates metabolism-secretion coupling by activation of various matrix enzymes, thus facilitating…”
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IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake by Deak, Andras T, Blass, Sandra, Khan, Muhammad J, Groschner, Lukas N, Waldeck-Weiermair, Markus, Hallström, Seth, Graier, Wolfgang F, Malli, Roland

“…Mitochondria contribute to cell signaling by controlling store-operated Ca(2+) entry (SOCE). SOCE is activated by Ca(2+) release from the endoplasmic reticulum…”
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Na+ current properties in islet α‐ and β‐cells reflect cell‐specific Scn3a and Scn9a expression by Zhang, Quan, Chibalina, Margarita V., Bengtsson, Martin, Groschner, Lukas N., Ramracheya, Reshma, Rorsman, Nils J. G., Leiss, Veronika, Nassar, Mohammed A., Welling, Andrea, Gribble, Fiona M., Reimann, Frank, Hofmann, Franz, Wood, John N., Ashcroft, Frances M., Rorsman, Patrik

“…Key points α‐ and β‐cells express both Nav1.3 and Nav1.7 Na+ channels but in different relative amounts. The differential expression explains the different…”
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NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes by Pessentheiner, Ariane R., Pelzmann, Helmut J., Walenta, Evelyn, Schweiger, Martina, Groschner, Lukas N., Graier, Wolfgang F., Kolb, Dagmar, Uno, Kyosuke, Miyazaki, Toh, Nitta, Atsumi, Rieder, Dietmar, Prokesch, Andreas, Bogner-Strauss, Juliane G.

“…NAT8L (N-acetyltransferase 8-like) catalyzes the formation of N-acetylaspartate (NAA) from acetyl-CoA and aspartate. In the brain, NAA delivers the acetate…”
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Molecularly Distinct Routes of Mitochondrial Ca2+ Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca2+ ATPase (SERCA) by Waldeck-Weiermair, Markus, Deak, András T., Groschner, Lukas N., Alam, Muhammad Rizwan, Jean-Quartier, Claire, Malli, Roland, Graier, Wolfgang F.

“…The transfer of Ca2+ across the inner mitochondrial membrane is an important physiological process linked to the regulation of metabolism, signal transduction,…”
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Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease by Forbes, Josephine M, Ke, Bi-Xia, Nguyen, Tuong-Vi, Henstridge, Darren C, Penfold, Sally A, Laskowski, Adrienne, Sourris, Karly C, Groschner, Lukas N, Cooper, Mark E, Thorburn, David R, Coughlan, Melinda T

“…Defects in the activity of enzyme complexes of the mitochondrial respiratory chain are thought to be responsible for several disorders, including renal…”
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The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1-Orai1 interaction by Deak, Andras T, Groschner, Lukas N, Alam, Muhammad Rizwan, Seles, Elisabeth, Bondarenko, Alexander I, Graier, Wolfgang F, Malli, Roland

“…The endocannabiniod anandamide (AEA) and its derivate N-arachidonoyl glycine (NAGly) have a broad spectrum of physiological effects, which are induced by both…”
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Metabolism–Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic β-Cells by Groschner, Lukas N., Alam, Muhammad Rizwan, Graier, Wolfgang F.

“…Pancreatic β-cells are the only cells capable of lowering blood glucose by secreting insulin. The β-cell continuously adjusts its secretory activity to…”
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Assessment of mitochondrial Ca²⁺ uptake by Deak, András T, Jean-Quartier, Claire, Bondarenko, Alexander I, Groschner, Lukas N, Malli, Roland, Graier, Wolfgang F, Waldeck-Weiermair, Markus

“…Mitochondrial Ca(2+) uptake regulates mitochondrial function and contributes to cell signaling. Accordingly, quantifying mitochondrial Ca(2+) signals and…”
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ATP increases within the lumen of the endoplasmic reticulum upon intracellular Ca 2+ release by Vishnu, Neelanjan, Jadoon Khan, Muhammad, Karsten, Felix, Groschner, Lukas N., Waldeck-Weiermair, Markus, Rost, Rene, Hallström, Seth, Imamura, Hiromi, Graier, Wolfgang F., Malli, Roland

“…Multiple functions of the endoplasmic reticulum (ER) essentially depend on ATP within this organelle. However, little is known about ER ATP dynamics and the…”
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