Search Results - "Gropp, Roswitha"

Humanized NSG Mouse Models as a Preclinical Tool for Translational Research in Inflammatory Bowel Diseases by Weß, Veronika, Schuster-Winkelmann, Paula, Karatekin, Yasemin Hazal, Malik, Simge, Beigel, Florian, Kühn, Florian, Gropp, Roswitha

“…The development of animal models reflecting the pathologies of ulcerative colitis (UC) and Crohn's disease (CD) remains a major challenge. The NOD/SCID/IL2rγ…”
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Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis by Jodeleit, Henrika, Milchram, Lisa, Soldo, Regina, Beikircher, Gabriel, Schönthaler, Silvia, Al-Amodi, Omar, Wolf, Eckhard, Beigel, Florian, Weinhäusel, Andreas, Siebeck, Matthias, Gropp, Roswitha

“…To date, no comprehensive analysis of autoantibodies in sera of patients with ulcerative colitis has been conducted. To analyze the spectrum of autoantibodies…”
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Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model by Jodeleit, Henrika, Palamides, Pia, Beigel, Florian, Mueller, Thomas, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha

“…Ulcerative colitis (UC) is a highly progressive inflammatory disease that requires the interaction of epithelial, immune, endothelial and muscle cells and…”
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Targeting ulcerative colitis by suppressing glucose uptake with ritonavir by Jodeleit, Henrika, Al-Amodi, Omar, Caesar, Janina, Villarroel Aguilera, Christina, Holdt, Lesca, Gropp, Roswitha, Beigel, Florian, Siebeck, Matthias

“…Glucose is the preferred source of energy in activated inflammatory cells. Glucose uptake into the cell is ensured by a family of glucose uptake transporters…”
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NOD/Scid IL2Rγnull Mice Reconstituted with PBMCs from Patients with Atopic Dermatitis or Psoriasis Vulgaris Reflect the Respective Phenotype by Schindler, Marietta, Schuster-Winkelmann, Paula, Weß, Veronika, Czell, Sophia, Rueff, Franziska, Wollenberg, Andreas, Siebeck, Matthias, Gropp, Roswitha

“…NSG (NOD/Scid IL2Rγnull) mice reconstituted with PBMCs donated by patients with ulcerative colitis or Crohn’s disease highly reflect the respective…”
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The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease by Winkelmann, Paula, Unterweger, Anna‐Lena, Khullar, Diya, Beigel, Florian, Koletzko, Leandra, Siebeck, Matthias, Gropp, Roswitha

“…With glucose being the preferred source of energy in activated T cells, targeting glycolysis has become an attractive therapeutic intervention point for…”
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Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells by Jodeleit, Henrika, Winkelmann, Paula, Caesar, Janina, Sterz, Sebastian, Holdt, Lesca M, Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, Bartnik, Eckart, Leeuw, Thomas, Siebeck, Matthias, Gropp, Roswitha

“…This study's aim was to demonstrate that the combination of patient immune profiling and testing in a humanized mouse model of ulcerative colitis (UC) might…”
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NOD/scid IL‐2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype by Unterweger, Anna‐Lena, Rüscher, Alena, Seuß, Marietta, Winkelmann, Paula, Beigel, Florian, Koletzko, Leandra, Breiteneicher, Simone, Siebeck, Matthias, Gropp, Roswitha, Aszodi, Attila

“…Introduction Crohn's disease (CD) is characterized by pronounced intestinal fibrosis and severe mucosal damage and conventional animal models are limited to…”
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A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals by Palamides, Pia, Jodeleit, Henrika, Föhlinger, Michael, Beigel, Florian, Herbach, Nadja, Mueller, Thomas, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha

“…Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset of disease and…”
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NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways by Zadeh-Khorasani, Maryam, Nolte, Thomas, Mueller, Thomas D, Pechlivanis, Markos, Rueff, Franziska, Wollenberg, Andreas, Fricker, Gert, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha

“…Animal models of human inflammatory diseases have limited predictive quality for human clinical trials for various reasons including species specific…”
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Induction of oxazolone mediated features of atopic dermatitis in NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells by Nolte, Thomas, Zadeh-Khorasani, Maryam, Safarov, Orkhan, Rueff, Franziska, Varga, Rita, Herbach, Nadja, Wanke, Rüdiger, Wollenberg, Andreas, Mueller, Thomas, Gropp, Roswitha, Wolf, Eckhard, Siebeck, Matthias

“…Summary Animal models mimicking human diseases have been used extensively to study the pathogenesis of autoimmune diseases and the efficacy of potential…”
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CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis by Al-amodi, Omar, Jodeleit, Henrika, Beigel, Florian, Wolf, Eckhard, Siebeck, Matthias, Gropp, Roswitha

“…Abstract Background CD1a-expressing CD14+ monocytes have been identified as inducers of autoreactive T cells. In this study, the link between inflammatory and…”
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Su1733 ORAL IL-23R ANTAGONIST MINIPROTEIN MB1 IS AS EFFECTIVE AS GUSELKUMAB IN A PRECLINICAL MODEL OF COLITIS by Berger, Stephanie, Seeger, Franziska, Yu, Ta-Yi, Aydin, Merve, Glassman, Caleb, Arguinchona, Lauren, Sniezek, Catherine, Blackstone, Alyssa, Carter, Lauren, Ravichandran, Rashmi, Ahlrichs, Maggie, Murphy, Michael P., Pultz, Ingrid S., Kang, Alex, Bera, Asim, Stewart, Lance, Garcia, K. Christopher, Beigel, Florian, Siebeck, Matthias, Gropp, Roswitha, Baker, David

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Preclinical proof of principle for orally delivered Th17 antagonist miniproteins by Berger, Stephanie, Seeger, Franziska, Yu, Ta-Yi, Aydin, Merve, Yang, Huilin, Rosenblum, Daniel, Guenin-Macé, Laure, Glassman, Caleb, Arguinchona, Lauren, Sniezek, Catherine, Blackstone, Alyssa, Carter, Lauren, Ravichandran, Rashmi, Ahlrichs, Maggie, Murphy, Michael, Pultz, Ingrid Swanson, Kang, Alex, Bera, Asim K, Stewart, Lance, Garcia, K Christopher, Naik, Shruti, Spangler, Jamie B, Beigel, Florian, Siebeck, Matthias, Gropp, Roswitha, Baker, David

“…Interleukin (IL)-23 and IL-17 are well-validated therapeutic targets in autoinflammatory diseases. Antibodies targeting IL-23 and IL-17 have shown clinical…”
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The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid [IL2Ry[gamma].sup.null] Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab by Jodeleit, Henrika, Caesar, Janina, Aguilera, Christina Villarroel, Sterz, Sebastian, Holdt, Lesca, Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, EckartBartnik, Siebeck, Matthias, Gropp, Roswitha

“…Background: To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. This is partially due to…”
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The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ null Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab by Jodeleit, Henrika, Caesar, Janina, Villarroel Aguilera, Christina, Sterz, Sebastian, Holdt, Lesca, Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, Bartnik, Eckart, Siebeck, Matthias, Gropp, Roswitha

“…Abstract Background To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. This is partially…”
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Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis by Unterweger, Anna-Lena, Jensen, Morten Ø, Giordanetto, Fabrizio, Jogini, Vishwanath, Rüschher, Alena, Seuß, Marietta, Winkelmann, Paula, Koletzko, Leandra, Shaw, David E, Siebeck, Matthias, Gropp, Roswitha, Beigel, Florian, Aszodi, Attila

“…Abstract Background and Aims The potassium channel Kv1.3 is a potentially attractive therapeutic target in T cell-mediated inflammatory diseases, as the…”
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Perception of journal club seminars by medical doctoral students: results from five years of evaluation by Taverna, Mara, Bucher, Julian Nicolaus, Weniger, Maximilian, Gropp, Roswitha, Lee, Serene M L, Mayer, Barbara, Werner, Jens, Bazhin, Alexandr V

“…A journal club is one of the well-established and popular methods of post-graduate education. In this work, we were interested to understand how the…”
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Design of Glycoengineered IL‑4 Antagonists Employing Chemical and Biosynthetic Glycosylation by Thomas, Sarah, Fiebig, Juliane E., Kuhn, Eva-Maria, Mayer, Dominik S., Filbeck, Sebastian, Schmitz, Werner, Krischke, Markus, Gropp, Roswitha, Mueller, Thomas D.

“…Interleukin-4 (IL-4) plays a key role in atopic diseases. It coordinates T-helper cell differentiation to subtype 2, thereby directing defense toward humoral…”
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Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cells by Nolte, Thomas, Zadeh-Khorasani, Maryam, Safarov, Orkhan, Rueff, Franziska, Varga, Rita, Herbach, Nadja, Wanke, Rüdiger, Wollenberg, Andreas, Mueller, Thomas, Gropp, Roswitha, Wolf, Eckhard, Siebeck, Matthias

“…Animal models mimicking human diseases have been used extensively to study the pathogenesis of autoimmune diseases and the efficacy of potential therapeutics…”
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