Search Results - "Groothuis, M."

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models by van Midwoud, Paul M, Janse, Arnout, Merema, Marjolijn T, Groothuis, Geny M. M, Verpoorte, Elisabeth

“…Microfluidic technology is providing new routes toward advanced cell and tissue culture models to better understand human biology and disease. Many advanced…”
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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction by Martignoni, Marcella, Groothuis, Geny M M, de Kanter, Ruben

“…Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds in humans. It is, however,…”
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A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices by van Midwoud, Paul M, Merema, Marjolijn T, Verpoorte, Elisabeth, Groothuis, Geny M M

“…Over the past two decades, it has become increasingly clear that the intestine, in addition to the liver, plays an important role in the metabolism of…”
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Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies by de Graaf, Inge A M, Olinga, Peter, de Jager, Marina H, Merema, Marjolijn T, de Kanter, Ruben, van de Kerkhof, Esther G, Groothuis, Geny M M

“…Precision-cut tissue slices (PCTS) are viable ex vivo explants of tissue with a reproducible, well defined thickness. They represent a mini-model of the organ…”
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Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach by Vatakuti, Suresh, Olinga, Peter, Pennings, Jeroen L. A., Groothuis, Geny M. M.

“…Hepatotoxicity is one of the major reasons for withdrawal of drugs from the market. Therefore, there is a need to screen new drugs for hepatotoxicity in humans…”
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Influence of inflammation on voriconazole metabolism by Encalada Ventura, M A, Span, L F R, van den Heuvel, E R, Groothuis, G M M, Alffenaar, J-W C

“…Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes…”
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Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices by Oenema, Tjitske A, Maarsingh, Harm, Smit, Marieke, Groothuis, Geny M M, Meurs, Herman, Gosens, Reinoud

“…Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to…”
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The effect of antifibrotic drugs in rat precision-cut fibrotic liver slices by Westra, Inge M, Oosterhuis, Dorenda, Groothuis, Geny M M, Olinga, Peter

“…Two important signaling pathways in liver fibrosis are the PDGF- and TGFβ pathway and compounds inhibiting these pathways are currently developed as…”
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Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies by Hewitt, Nicola J., Gómez Lechón, María José, Houston, J. Brian, Hallifax, David, Brown, Hayley S., Maurel, Patrick, Kenna, J. Gerald, Gustavsson, Lena, Lohmann, Christina, Skonberg, Christian, Guillouzo, Andre, Tuschl, Gregor, Li, Albert P., LeCluyse, Edward, Groothuis, Geny M. M., Hengstler, Jan G.

“…This review brings you up-to-date with the hepatocyte research on: 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction,…”
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Time-varying covariates and coefficients in Cox regression models by Zhang, Zhongheng, Reinikainen, Jaakko, Adeleke, Kazeem Adedayo, Pieterse, Marcel E, Groothuis-Oudshoorn, Catharina G M

“…Time-varying covariance occurs when a covariate changes over time during the follow-up period. Such variable can be analyzed with the Cox regression model to…”
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Human Precision-Cut Liver Slices as an ex Vivo Model to Study Idiosyncratic Drug-Induced Liver Injury by Hadi, Mackenzie, Westra, Inge M, Starokozhko, Viktoriia, Dragovic, Sanja, Merema, Marjolijn T, Groothuis, Geny M. M

“…Idiosyncratic drug-induced liver injury (IDILI) is a major problem during drug development and has caused drug withdrawal and black-box warnings. Because of…”
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Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days by Starokozhko, Viktoriia, Vatakuti, Suresh, Schievink, Bauke, Merema, Marjolijn T., Asplund, Annika, Synnergren, Jane, Aspegren, Anders, Groothuis, Geny M. M.

“…Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme…”
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Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices by Vatakuti, Suresh, Pennings, Jeroen L. A, Gore, Emilia, Olinga, Peter, Groothuis, Geny M. M

“…Human toxicity screening is an important stage in the development of safe drug candidates. Hepatotoxicity is one of the major reasons for the withdrawal of…”
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Exploring the importance of controlling heteroskedasticity and heterogeneity in health valuation: a case study on Dutch EQ-5D-5L by Karim, Suzana, Craig, Benjamin M, Groothuis-Oudshoorn, Catharina G M

“…Respondents in a health valuation study may have different sources of error (i.e., heteroskedasticity), tastes (differences in the relative effects of each…”
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs by Westra, Inge M., Oosterhuis, Dorenda, Groothuis, Geny M.M., Olinga, Peter

“…Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to…”
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Advances in the clinical management of high‐risk Wilms tumors by Ortiz, Michael V., Koenig, Christa, Armstrong, Amy E., Brok, Jesper, Camargo, Beatriz, Mavinkurve‐Groothuis, Annelies M. C., Herrera, Thelma B. Velasquez, Venkatramani, Rajkumar, Woods, Andrew D., Dome, Jeffrey S., Spreafico, Filippo

“…Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50%…”
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Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin by Han, Jiaying, Räder, Andreas F. B, Reichart, Florian, Aikman, Brech, Wenzel, Margot N, Woods, Ben, Weinmüller, Michael, Ludwig, Beatrice S, Stürup, Stefan, Groothuis, Geny M. M, Permentier, Hjalmar P, Bischoff, Rainer, Kessler, Horst, Horvatovich, Peter, Casini, Angela

“…Cisplatin occupies a crucial role in the treatment of various malignant tumors. However, its efficacy and applicability are heavily restricted by severe…”
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Effectiveness of a Wilms tumour treatment guideline adapted to local circumstances in sub‐Saharan Africa: A report from Wilms Africa Phase II—CANCaRe Africa by Fufa, Diriba, Mdoka, Cecilia, Ayalew, Mulugeta, Khofi, Harriet, Amankwah, Emmanuel, Chokwenda, Nester, Mezgebu, Esubalew, Mavinkurve‐Groothuis, Annelies M. C., Kamiza, Steve, Chikaphonya‐Phiri, Beatrice, Wassie, Mulugeta, Atwiine, Barnabas, Branchard, Mushabe, Gorostegui, Maite, Parkes, Jeannette, Kudowa, Evaristar, Eklu, Bernice, Jator, Brian, Renner, Lorna Awo, Borgstein, Eric, Molyneux, Elizabeth, Kouya, Francine, Pritchard‐Jones, Kathy, Paintsil, Vivian, Chitsike, Inam, Chagaluka, George, Israels, Trijn

“…Background Wilms tumour (WT) is one of the cancer types targeted by the Global Initiative for Childhood Cancer (GICC). The objective of this study was to…”
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Comment on: Cardiotoxicity in children with cancer treated with anthracyclines: A position statement on dexrazoxane by Mavinkurve‐Groothuis, Annelies M. C., Baat, Esmee C., Feijen, Elizabeth A. M., Kremer, Leontien C. M., Armenian, Saro H., Mulder, Renee L., Dalen, Elvira C.

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Advances in the clinical management of high‐risk Wilms tumors by Ortiz, Michael V., Koenig, Christa, Armstrong, Amy E., Brok, Jesper, Camargo, Beatriz, Mavinkurve‐Groothuis, Annelies M. C., Herrera, Thelma B. Velasquez, Venkatramani, Rajkumar, Woods, Andrew D., Dome, Jeffrey S., Spreafico, Filippo

“…Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50%…”
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