Search Results - "Groot Koerkamp, Marian J."

Uterine Selection of Human Embryos at Implantation by Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., Šućurović, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S.

“…Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first…”
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EBV MicroRNA BART16 Suppresses Type I IFN Signaling by Hooykaas, Marjolein J G, van Gent, Michiel, Soppe, Jasper A, Kruse, Elisabeth, Boer, Ingrid G J, van Leenen, Dik, Groot Koerkamp, Marian J A, Holstege, Frank C P, Ressing, Maaike E, Wiertz, Emmanuel J H J, Lebbink, Robert Jan

“…Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response…”
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The genomic landscape of compensatory evolution by Szamecz, Béla, Boross, Gábor, Kalapis, Dorottya, Kovács, Károly, Fekete, Gergely, Farkas, Zoltán, Lázár, Viktória, Hrtyan, Mónika, Kemmeren, Patrick, Groot Koerkamp, Marian J A, Rutkai, Edit, Holstege, Frank C P, Papp, Balázs, Pál, Csaba

“…Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural…”
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Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma by DeMartino, Jeff, Meister, Michael T., Visser, Lindy L., Brok, Mariël, Groot Koerkamp, Marian J. A., Wezenaar, Amber K. L., Hiemcke-Jiwa, Laura S., de Souza, Terezinha, Merks, Johannes H. M., Rios, Anne C., Holstege, Frank C. P., Margaritis, Thanasis, Drost, Jarno

“…Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic…”
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An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF by Koot, Yvonne E. M., van Hooff, Sander R., Boomsma, Carolien M., van Leenen, Dik, Groot Koerkamp, Marian J. A., Goddijn, Mariëtte, Eijkemans, Marinus J. C., Fauser, Bart C. J. M., Holstege, Frank C. P., Macklon, Nick S.

“…The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples…”
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Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency by Brinkhof, Bas, van Tol, Helena T A, Groot Koerkamp, Marian J A, Wubbolts, Richard W, Haagsman, Henk P, Roelen, Bernard A J

“…In mammalian preimplantation development, pluripotent cells are set aside from cells that contribute to extra-embryonic tissues. Although the pluripotent cell…”
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Balancing of Histone H3K4 Methylation States by the Kdm5c/SMCX Histone Demethylase Modulates Promoter and Enhancer Function by Outchkourov, Nikolay S., Muiño, Jose M., Kaufmann, Kerstin, van IJcken, Wilfred F.J., Koerkamp, Marian J. Groot, van Leenen, Dik, de Graaf, Petra, Holstege, Frank C.P., Grosveld, Frank G., Timmers, H.T. Marc

“…The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers…”
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Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy by van der Vos, Kristan E., Eliasson, Pernilla, Proikas-Cezanne, Tassula, Vervoort, Stephin J., van Boxtel, Ruben, Putker, Marrit, van Zutphen, Iris J., Mauthe, Mario, Zellmer, Sebastian, Pals, Cornelieke, Verhagen, Liesbeth P., Groot Koerkamp, Marian J. A., Braat, A. Koen, Dansen, Tobias B., Holstege, Frank C., Gebhardt, Rolf, Burgering, Boudewijn M., Coffer, Paul J.

“…The PI(3)K–PKB–FOXO signalling network provides a major intracellular hub for the regulation of cell proliferation, survival and stress resistance. Here we…”
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Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo by de Bruin, Alain, A Cornelissen, Peter W, Kirchmaier, Bettina C, Mokry, Michal, Iich, Elhadi, Nirmala, Ella, Liang, Kuo-Hsuan, D Végh, Anna M, Scholman, Koen T, Groot Koerkamp, Marian J, Holstege, Frank C, Cuppen, Edwin, Schulte-Merker, Stefan, Bakker, Walbert J

“…In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is…”
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Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies by Raaben, Matthijs, Groot Koerkamp, Marian J. A., Rottier, Peter J. M., De Haan, Cornelis A. M.

“…Summary Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we…”
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Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2 by Hoekstra, Elisa J, von Oerthel, Lars, van der Heide, Lars P, Kouwenhoven, Willemieke M, Veenvliet, Jesse V, Wever, Iris, Jin, Yong-Ri, Yoon, Jeong K, van der Linden, Annemarie J A, Holstege, Frank C P, Groot Koerkamp, Marian J, Smidt, Marten P

“…Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors…”
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Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog by Boerkamp, Kim M, van der Kooij, Marieke, van Steenbeek, Frank G, van Wolferen, Monique E, Groot Koerkamp, Marian J A, van Leenen, Dik, Grinwis, Guy C M, Penning, Louis C, Wiemer, Erik A C, Rutteman, Gerard R

“…The determination of altered expression of genes in specific tumor types and their effect upon cellular processes may create insight in tumorigenesis and help…”
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A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions by Sameith, Katrin, Amini, Saman, Groot Koerkamp, Marian J A, van Leenen, Dik, Brok, Mariel, Brabers, Nathalie, Lijnzaad, Philip, van Hooff, Sander R, Benschop, Joris J, Lenstra, Tineke L, Apweiler, Eva, van Wageningen, Sake, Snel, Berend, Holstege, Frank C P, Kemmeren, Patrick

“…Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these…”
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Expression Profiling after Prolonged Experimental Febrile Seizures in Mice Suggests Structural Remodeling in the Hippocampus by Jongbloets, Bart C, van Gassen, Koen L I, Kan, Anne A, Olde Engberink, Anneke H O, de Wit, Marina, Wolterink-Donselaar, Inge G, Groot Koerkamp, Marian J A, van Nieuwenhuizen, Onno, Holstege, Frank C P, de Graan, Pierre N E

“…Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are…”
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The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression by Boerkamp, Kim M, van Steenbeek, Frank G, Penning, Louis C, Groot Koerkamp, Marian J A, van Leenen, Dik, Vos-Loohuis, Manon, Grinwis, Guy C M, Rutteman, Gerard R

“…Examination of gene functions in specific tumor types improves insight in tumorigenesis and helps design better treatments. Due to the rarity of…”
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Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors by Geest, Christian R., Buitenhuis, Miranda, Groot Koerkamp, Marian J.A., Holstege, Frank C.P., Vellenga, Edo, Coffer, Paul J.

“…A plethora of extracellular stimuli regulate growth, survival, and differentiation responses through activation of the MEK-ERK MAPK signaling module. Using…”
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Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells by Korzelius, Jerome, The, Inge, Ruijtenberg, Suzan, Prinsen, Martine B W, Portegijs, Vincent, Middelkoop, Teije C, Groot Koerkamp, Marian J, Holstege, Frank C P, Boxem, Mike, van den Heuvel, Sander

“…Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal…”
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Cell cycle population effects in perturbation studies by O'Duibhir, Eoghan, Lijnzaad, Philip, Benschop, Joris J, Lenstra, Tineke L, van Leenen, Dik, Groot Koerkamp, Marian JA, Margaritis, Thanasis, Brok, Mariel O, Kemmeren, Patrick, Holstege, Frank CP

“…Growth condition perturbation or gene function disruption are commonly used strategies to study cellular systems. Although it is widely appreciated that such…”
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Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice by Lesscher, Heidi M B, Houthuijzen, Julia M, Groot Koerkamp, Marian J, Holstege, Frank C P, Vanderschuren, Louk J M J

“…Alcoholism is a devastating brain disorder that affects millions of people worldwide. The development of alcoholism is caused by alcohol-induced maladaptive…”
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Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases by Snoeren, Nikol, van Hooff, Sander R, Adam, Rene, van Hillegersberg, Richard, Voest, Emile E, Guettier, Catherine, van Diest, Paul J, Nijkamp, Maarten W, Brok, Mariel O, van Leenen, Dik, Koerkamp, Marian J A Groot, Holstege, Frank C P, Rinkes, Inne H M Borel

“…This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for…”
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