Search Results - "Groop, Leif"

Epigenetics: a molecular link between environmental factors and type 2 diabetes by Ling, Charlotte, Groop, Leif

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Genetics of diabetes – Are we missing the genes or the disease? by Groop, Leif, Pociot, Flemming

“…•Diabetes is a more heterogenous disease than a simple subdivision into type 1 and type 2 diabetes assumes.•Genetics has delivered – we have learnt more about…”
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Genetics of type 2 diabetes-pitfalls and possibilities by Prasad, Rashmi B, Groop, Leif

“…Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between genetic, epigenetic and environmental factors. While the major…”
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The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants by Fadista, João, Manning, Alisa K, Florez, Jose C, Groop, Leif

“…Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false…”
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The genetics of diabetic complications by Ahlqvist, Emma, van Zuydam, Natalie R., Groop, Leif C., McCarthy, Mark I.

“…Key Points The majority of the morbidity and mortality associated with diabetes mellitus is due to complications, such as diabetic kidney disease A limited…”
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The many faces of diabetes: a disease with increasing heterogeneity by Tuomi, Tiinamaija, MD, Santoro, Nicola, MD, Caprio, Sonia, Prof, Cai, Mengyin, MD, Weng, Jianping, Prof, Groop, Leif, Prof

“…Summary Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent…”
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LoFtool: a gene intolerance score based on loss-of-function variants in 60 706 individuals by Fadista, João, Oskolkov, Nikolay, Hansson, Ola, Groop, Leif

“…Depletion of loss-of-function (LoF) mutations may provide a rank of genic functional intolerance and consequently susceptibility to disease. Here we have…”
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100 YEARS OF INSULIN: Towards improved precision and a new classification of diabetes mellitus by Ahlqvist, Emma, Prasad, Rashmi B, Groop, Leif

“…Type 2 diabetes (T2D) is one of the fastest increasing diseases worldwide. Although it is defined by a single metabolite, glucose, it is increasingly…”
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes by Jaiswal, Siddhartha, Fontanillas, Pierre, Flannick, Jason, Manning, Alisa, Grauman, Peter V, Mar, Brenton G, Lindsley, R. Coleman, Mermel, Craig H, Burtt, Noel, Chavez, Alejandro, Higgins, John M, Moltchanov, Vladislav, Kuo, Frank C, Kluk, Michael J, Henderson, Brian, Kinnunen, Leena, Koistinen, Heikki A, Ladenvall, Claes, Getz, Gad, Correa, Adolfo, Banahan, Benjamin F, Gabriel, Stacey, Kathiresan, Sekar, Stringham, Heather M, McCarthy, Mark I, Boehnke, Michael, Tuomilehto, Jaakko, Haiman, Christopher, Groop, Leif, Atzmon, Gil, Wilson, James G, Neuberg, Donna, Altshuler, David, Ebert, Benjamin L

“…About 10% of people older than 70 years of age carry one or more mutations in their hematopoietic cells, and these persons have a higher relative risk of a…”
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Early metabolic markers identify potential targets for the prevention of type 2 diabetes by Peddinti, Gopal, Cobb, Jeff, Yengo, Loic, Froguel, Philippe, Kravić, Jasmina, Balkau, Beverley, Tuomi, Tiinamaija, Aittokallio, Tero, Groop, Leif

“…Aims/hypothesis The aims of this study were to evaluate systematically the predictive power of comprehensive metabolomics profiles in predicting the future…”
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Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis by Skyler, Jay S, Bakris, George L, Bonifacio, Ezio, Darsow, Tamara, Eckel, Robert H, Groop, Leif, Groop, Per-Henrik, Handelsman, Yehuda, Insel, Richard A, Mathieu, Chantal, McElvaine, Allison T, Palmer, Jerry P, Pugliese, Alberto, Schatz, Desmond A, Sosenko, Jay M, Wilding, John P H, Ratner, Robert E

“…The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened…”
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Prevalence and risk factors of gestational diabetes in Punjab, North India: results from a population screening program by Arora, Geeti P, Thaman, Richa G, Prasad, Rashmi B, Almgren, Peter, Brøns, Charlotte, Groop, Leif C, Vaag, Allan A

“…ObjectiveThe World Health Organization (WHO) has in 2013 changed the diagnostic criteria for gestational diabetes mellitus (GDM) to acknowledge the putative…”
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Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes by Bacos, Karl, Gillberg, Linn, Volkov, Petr, Olsson, Anders H, Hansen, Torben, Pedersen, Oluf, Gjesing, Anette Prior, Eiberg, Hans, Tuomi, Tiinamaija, Almgren, Peter, Groop, Leif, Eliasson, Lena, Vaag, Allan, Dayeh, Tasnim, Ling, Charlotte

“…Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes…”
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Genetics of type 2 diabetes by Ahlqvist, Emma, Ahluwalia, Tarunveer Singh, Groop, Leif

“…Type 2 diabetes (T2D) is a complex disorder that is affected by multiple genetic and environmental factors. Extensive efforts have been made to identify the…”
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A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes by Taira, Makiko, Imamura, Minako, Takahashi, Atsushi, Kamatani, Yoichiro, Yamauchi, Toshimasa, Araki, Shin-Ichi, Tanaka, Nobue, van Zuydam, Natalie R, Ahlqvist, Emma, Toyoda, Masao, Umezono, Tomoya, Kawai, Koichi, Imanishi, Masahito, Watada, Hirotaka, Suzuki, Daisuke, Maegawa, Hiroshi, Babazono, Tetsuya, Kaku, Kohei, Kawamori, Ryuzo, Groop, Leif C, McCarthy, Mark I, Kadowaki, Takashi, Maeda, Shiro

“…To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with…”
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A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue by Rönn, Tina, Volkov, Petr, Davegårdh, Cajsa, Dayeh, Tasnim, Hall, Elin, Olsson, Anders H, Nilsson, Emma, Tornberg, Asa, Dekker Nitert, Marloes, Eriksson, Karl-Fredrik, Jones, Helena A, Groop, Leif, Ling, Charlotte

“…Epigenetic mechanisms are implicated in gene regulation and the development of different diseases. The epigenome differs between cell types and has until now…”
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism by Fadista, João, Vikman, Petter, Laakso, Emilia Ottosson, Mollet, Inês Guerra, Esguerra, Jonathan Lou, Taneera, Jalal, Storm, Petter, Osmark, Peter, Ladenvall, Claes, Prasad, Rashmi B., Hansson, Karin B., Finotello, Francesca, Uvebrant, Kristina, Ofori, Jones K., Di Camillo, Barbara, Krus, Ulrika, Cilio, Corrado M., Hansson, Ola, Eliasson, Lena, Rosengren, Anders H., Renström, Erik, Wollheim, Claes B., Groop, Leif

“…Significance We provide a comprehensive catalog of novel genetic variants influencing gene expression and metabolic phenotypes in human pancreatic islets. The…”
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Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes by Lyssenko, Valeriya, Jonsson, Anna, Almgren, Peter, Pulizzi, Nicoló, Isomaa, Bo, Tuomi, Tiinamaija, Berglund, Göran, Altshuler, David, Nilsson, Peter, Groop, Leif

“…Sixteen SNPs were determined and clinical factors examined in two Scandinavian cohorts that were followed for a median of 23.5 years. Type 2 diabetes developed…”
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Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals by SAXENA, Richa, GIANNINY, Lauren, LINDBLAD, Ulf, DALY, Mark J, TUOMI, Tiinamaija, HIRSCHHORN, Joel N, ARDLIE, Kristin G, GROOP, Leif C, ALTSHULER, David, BURTT, Noël P, LYSSENKO, Valeriya, GIUDUCCI, Candace, SJÖGREN, Marketa, FLOREZ, Jose C, ALMGREN, Peter, ISOMAA, Bo, ORHO-MELANDER, Marju

“…Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic…”
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Identification of ten loci associated with height highlights new biological pathways in human growth by Hirschhorn, Joel N, Lettre, Guillaume, Jackson, Anne U, Gieger, Christian, Schumacher, Fredrick R, Berndt, Sonja I, Sanna, Serena, Eyheramendy, Susana, Voight, Benjamin F, Butler, Johannah L, Guiducci, Candace, Illig, Thomas, Hackett, Rachel, Heid, Iris M, Jacobs, Kevin B, Lyssenko, Valeriya, Uda, Manuela, Boehnke, Michael, Chanock, Stephen J, Groop, Leif C, Hu, Frank B, Isomaa, Bo, Kraft, Peter, Peltonen, Leena, Salomaa, Veikko, Schlessinger, David, Hunter, David J, Hayes, Richard B, Abecasis, Gonçalo R, Wichmann, H-Erich, Mohlke, Karen L

“…Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of…”
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