Search Results - "Groom, R C"

A review of methods for the calculation of solution free energies and the modelling of systems in solution by Skyner, R E, McDonagh, J L, Groom, C R, van Mourik, T, Mitchell, J B O

“…Over the past decade, pharmaceutical companies have seen a decline in the number of drug candidates successfully passing through clinical trials, though…”
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The druggable genome by Groom, Colin R, Hopkins, Andrew L

“…An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic…”
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High or low hematocrits during cardiopulmonary bypass for patients undergoing coronary artery bypass graft surgery? An evidence-based approach to the question by Groom, Robert C

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Parallel replacement of the oxygenator that is not transferring oxygen: the PRONTO procedure by Groom, R C, Forest, R J, Cormack, J E, Niimi, K S, Morton, J

“…We present here a technique to replace a failed oxygenator by inserting a second oxygenator in parallel (PRONTO) within the cardiopulmonary bypass (CPB)…”
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Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography by Böcskei, Zsolt, Groom, Colin R, Flower, Darren R, Wright, Charles E, Phillips, Simon E. V, Cavaggioni, Andrea, Findlay, John B. C, North, Anthony C. T

“…The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well…”
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Trimethoprim binds in a bacterial mode to the wild-type and E30D mutant of mouse dihydrofolate reductase by GROOM, C. R, THILLET, J, NORTH, A. C.T, PICTET, R, GEDDES, A. J

“…Previous crystallographic studies of the antibacterial trimethoprim in complexes with bacterial and avian dihydrofolate reductases have shown substantial…”
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Alternative method of ultrafiltration after cardiopulmonary bypass by Groom, Robert C., Akl, Bechara F., Albus, Robert A., Hill, Aaron, Munoz, Ruben, Lefrak, Edward A.

“…A revised circuit design for modified ultrafiltration is presented rendering the technique more convenient for use after cardiopulmonary bypass when blood…”
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Locating interaction sites on proteins: The crystal structure of thermolysin soaked in 2% to 100% isopropanol by English, Andrew C., Done, Sarah H., Caves, Leo S.D., Groom, Colin R., Hubbard, Roderick E.

“…Multiple‐solvent crystal structure determination (MSCS) allows the position and orientation of bound solvent fragments to be identified by determining the…”
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Experimental and computational mapping of the binding surface of a crystalline protein by English, Andrew C., Groom, Colin R., Hubbard, Roderick E.

“…Multiple Solvent Crystal Structures (MSCS) is a crystallographic technique to identify energetically favorable positions and orientations of small organic…”
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Crystallization and initial X-ray analysis of the C2-subunit of crustacyanin by Wright, C E, Rafferty, J B, Flower, D R, Groom, C R, Findlay, J B, North, A C, Phillips, S E, Zagalsky, P F

“…Crystals of the C2-subunit of crustacyanin have been grown from solutions containing ammonium sulphate and 2-methyl-2,4-pentanediol as co-precipitants. The…”
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Target analysis: a priori assessment of druggability by Hopkins, A L, Groom, C R

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Cannula length and arch flow erosion by Groom, Robert C., Hill, Aaron G., Akl, Bechara F., Speir, Alan M., Massimiano, Paul S., Lefrak, Edward A., Muehrcke, Derek D., Cosgrove, Delos M.

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Pediatric cardiopulmonary bypass: a review of current practice by Groom, R C, Akl, B F, Albus, R, Lefrak, E A

“…Devices and techniques used for pediatric cardiopulmonary bypass are ever changing. There are frequently reports in the literature about new techniques and new…”
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Cardiac assist devices by Hill, A G, Groom, R C, Burton, N A, Lefrak, E A

“…The two primary goals of mechanical circulatory support are to provide adequate perfusion of the vital organs and to decrease cardiac work. The support of the…”
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Size makes a difference: use of a low-prime cardiopulmonary bypass circuit and autologous priming in small adults by Cormack, John E, Forest, Richard J, Groom, Robert C, Morton, Jeremy

“…Low hematocrit (Hct < 20) during cardiopulmonary bypass (CPB) is associated with higher mortality and other adverse outcomes. More frequently, low Hct is…”
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Repair of hypoplastic left heart syndrome of a 4.25-kg Jehovah’s witness by Forest, Richard J, Groom, Robert C, Quinn, Reed, Donnelly, Jon, Clark, Cantwell

“…The care of patients who refuse homologous transfusions has challenged cardiac surgery teams to refine blood conservation techniques and question standard…”
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A model for cardiopulmonary bypass redesign by Groom, R C, Likosky, D S, Forest, R J, O’Connor, G T, Morton, J R, Ross, C S, Clark, C, Kramer, R

“…Introduction: A portion of patients undergoing cardiac surgery may develop focal and/or subtle brain injuries secondary to cardiac surgery. There is evidence…”
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Ligand efficiency: a useful metric for lead selection by Hopkins, Andrew L., Groom, Colin R., Alex, Alexander

“…Potency is not the only consideration when selecting a lead compound for further optimization into a drug, but it does hold a powerful attraction to the…”
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Three-dimensional structure of diferric bovine lactoferrin at 2.8 Å resolution by Moore, Stanley A, Anderson, Bryan F, Groom, Colin R, Haridas, M, Baker, Edward N

“…The three-dimensional structure of diferric bovine lactoferrin (bLf) has been determined by X-ray crystallography in order to investigate the factors that…”
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Rapid cooling: a potentially dangerous practice by Groom, R C, Hill, A G, Akl, B, Lefrak, E A, Kurusz, M

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