Search Results - "Groom, Joanna R"

CXCR3 ligands: redundant, collaborative and antagonistic functions by Groom, Joanna R, Luster, Andrew D

“…CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation, and preferentially remains highly expressed on type‐1 helper…”
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CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation by Groom, Joanna R., Richmond, Jillian, Murooka, Thomas T., Sorensen, Elizabeth W., Sung, Jung Hwan, Bankert, Katherine, von Andrian, Ulrich H., Moon, James J., Mempel, Thorsten R., Luster, Andrew D.

“…Differentiation of naive CD4+ T cells into T helper (Th) cells is a defining event in adaptive immunity. The cytokines and transcription factors that control…”
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Type I interferon induces CXCL13 to support ectopic germinal center formation by Denton, Alice E, Innocentin, Silvia, Carr, Edward J, Bradford, Barry M, Lafouresse, Fanny, Mabbott, Neil A, Mörbe, Urs, Ludewig, Burkhard, Groom, Joanna R, Good-Jacobson, Kim L, Linterman, Michelle A

“…Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection,…”
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Nfil3 is required for the development of all innate lymphoid cell subsets by Seillet, Cyril, Rankin, Lucille C, Groom, Joanna R, Mielke, Lisa A, Tellier, Julie, Chopin, Michael, Huntington, Nicholas D, Belz, Gabrielle T, Carotta, Sebastian

“…Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is…”
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Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands by Duckworth, Brigette C., Lafouresse, Fanny, Wimmer, Verena C., Broomfield, Benjamin J., Dalit, Lennard, Alexandre, Yannick O., Sheikh, Amania A., Qin, Raymond Z., Alvarado, Carolina, Mielke, Lisa A., Pellegrini, Marc, Mueller, Scott N., Boudier, Thomas, Rogers, Kelly L., Groom, Joanna R.

“…T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to…”
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Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes by Sung, Jung Hwan, Zhang, Han, Moseman, E. Ashley, Alvarez, David, Iannacone, Matteo, Henrickson, Sarah E., de la Torre, Juan C., Groom, Joanna R., Luster, Andrew D., von Andrian, Ulrich H.

“…A defining feature of vertebrate immunity is the acquisition of immunological memory, which confers enhanced protection against pathogens by mechanisms that…”
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A Task Force Against Local Inflammation and Cancer: Lymphocyte Trafficking to and Within the Skin by Lafouresse, Fanny, Groom, Joanna R

“…The skin represents a specialized site for immune surveillance consisting of resident, inflammatory and memory populations of lymphocytes. The entry and…”
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The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses by Kealy, Liam, Di Pietro, Andrea, Hailes, Lauren, Scheer, Sebastian, Dalit, Lennard, Groom, Joanna R., Zaph, Colby, Good-Jacobson, Kim L.

“…Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The recruitment of the histone…”
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Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection by Sheikh, Amania A., Cooper, Lucy, Feng, Meiqi, Souza-Fonseca-Guimaraes, Fernando, Lafouresse, Fanny, Duckworth, Brigette C., Huntington, Nicholas D., Moon, James J., Pellegrini, Marc, Nutt, Stephen L., Belz, Gabrielle T., Good-Jacobson, Kim L., Groom, Joanna R.

“…Following infection, inflammatory cues upregulate core transcriptional programs to establish pathogen-specific protection. In viral infections, T follicular…”
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Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria by Ly, Ann, Liao, Yang, Pietrzak, Halina, Ioannidis, Lisa J., Sidwell, Tom, Gloury, Renee, Doerflinger, Marcel, Triglia, Tony, Qin, Raymond Z., Groom, Joanna R., Belz, Gabrielle T., Good-Jacobson, Kim L., Shi, Wei, Kallies, Axel, Hansen, Diana S.

“…Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully…”
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c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses by Piovesan, Dana, Tempany, Jessica, Di Pietro, Andrea, Baas, Inge, Yiannis, Callisthenis, O’Donnell, Kristy, Chen, Yunshun, Peperzak, Victor, Belz, Gabrielle T., Mackay, Charles R., Smyth, Gordon K., Groom, Joanna R., Tarlinton, David M., Good-Jacobson, Kim L.

“…Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to…”
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CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter by Prizant, Hen, Patil, Nilesh, Negatu, Seble, Bala, Noor, McGurk, Alexander, Leddon, Scott A., Hughson, Angela, McRae, Tristan D., Gao, Yu-Rong, Livingstone, Alexandra M., Groom, Joanna R., Luster, Andrew D., Fowell, Deborah J.

“…Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must…”
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Regulators of T‐cell fate: Integration of cell migration, differentiation and function by Groom, Joanna R.

“…Summary A fundamental question in immunology is how cells decide between distinct T helper, effector or memory differentiation fates. These decisions are…”
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Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses by Cooper, Lucy, Hailes, Lauren, Sheikh, Amania, Zaph, Colby, Belz, Gabrielle T, Groom, Joanna R, Good-Jacobson, Kim L

“…Successful T-dependent humoral responses require the production of antibody-secreting plasmablasts, as well as the formation of germinal centers which…”
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Tailoring Immune Responses toward Autoimmunity: Transcriptional Regulators That Drive the Creation and Collusion of Autoreactive Lymphocytes by Good-Jacobson, Kim L, Groom, Joanna R

“…T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby…”
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Diversity in science requires mentoring for all, by all by Groom, Joanna R.

“…If we believe immunology is for everyone, it is time to rethink who and how we mentor…”
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CXCR3 in T cell function by Groom, Joanna R., Luster, Andrew D.

“…CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an important role in T cell trafficking and function. CXCR3 is rapidly…”
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Macro-clusters: CD301b+ DCs prime Th2 responses by Abberger, Hanna, Groom, Joanna R

“…In this issue of JEM, Lyons-Cohen et al. (https://doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+…”
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Defining the niche for stem-like CD8+ T cell formation and function by Broomfield, Benjamin J, Groom, Joanna R

“…TCF-1+ CD8+ T cell populations have emerged as critical determinants for long-lived immunological memory. This cell population has stem-like properties and is…”
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Conversations that count: Cellular interactions that drive T cell fate by Duckworth, Brigette C., Groom, Joanna R.

“…The relationship between the extrinsic environment and the internal transcriptional network is circular. Naive T cells first engage with antigen‐presenting…”
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