Search Results - "Groom, Harriet C. T."

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase by Goldstone, David C., Ennis-Adeniran, Valerie, Hedden, Joseph J., Groom, Harriet C. T., Rice, Gillian I., Christodoulou, Evangelos, Walker, Philip A., Kelly, Geoff, Haire, Lesley F., Yap, Melvyn W., de Carvalho, Luiz Pedro S., Stoye, Jonathan P., Crow, Yanick J., Taylor, Ian A., Webb, Michelle

“…Antiretroviral role for SAMHD1 protein Mutations in SAMHD1 protein are associated with the human autoimmune disease Aicardi–Goutières syndrome, and SAMHD1 was…”
Get full text

Structural basis of lentiviral subversion of a cellular protein degradation pathway by Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.

“…The crystal structure of a ternary complex of the lentiviral accessory protein Vpx with the E3 ligase substrate adaptor DCAF1 and the HIV-1 restriction factor…”
Get full text

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells by Tsai, Ming-Han C, Caswell, Sarah J, Morris, Elizabeth R, Mann, Melanie C, Pennell, Simon, Kelly, Geoff, Groom, Harriet C T, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and…”
Get full text

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors by Groom, Harriet C.T, Yap, Melvyn W, Galão, Rui Pedro, Neil, Stuart J.D, Bishop, Kate N

“…Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic fatigue…”
Get full text

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome by Groom, Harriet C T, Boucherit, Virginie C, Makinson, Kerry, Randal, Edward, Baptista, Sarah, Hagan, Suzanne, Gow, John W, Mattes, Frank M, Breuer, Judith, Kerr, Jonathan R, Stoye, Jonathan P, Bishop, Kate N

“…Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome…”
Get full text

No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses by Groom, Harriet C T, Warren, Anne Y, Neal, David E, Bishop, Kate N

“…The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of…”
Get full text

Rev regulates translation of human immunodeficiency virus type 1 RNAs by Groom, Harriet C. T, Anderson, Emma C, Dangerfield, John A, Lever, Andrew M. L

“…1 Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK 2 Department of Biological Sciences, University of Warwick, Warwick CV4 7AL, UK 3…”
Get full text

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction by Arnold, Laurence H, Groom, Harriet C T, Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J, Ordonez, Paula, Mann, Melanie C, Rueschenbaum, Sabrina, Goldstone, David C, Pennell, Simon, Howell, Steven A, Stoye, Jonathan P, Webb, Michelle, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase…”
Get full text

tale of xenotropic murine leukemia virus-related virus by Groom, Harriet C. T, Bishop, Kate N

“…In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially…”
Get full text

Duplex formation between the template and the nascent strand in the transcription-regulating sequences is associated with the site of template switching in SARS - CoV-2 by D'Souza, Aaron R., Buckingham, Amanda B., Salasc, Fanny, Ingemarsdotter, Carin K., Iaconis, Gennaro, Jarvis, Isobel, Groom, Harriet C. T., Kenyon, Julia C., Lever, Andrew M. L.

“…Recently published transcriptomic data of the SARS-CoV-2 coronavirus show that there is a large variation in the frequency and steady state levels of…”
Get full text

SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells by Ordonez, Paula, Kunzelmann, Simone, Groom, Harriet C. T., Yap, Melvyn W., Weising, Simon, Meier, Chris, Bishop, Kate N., Taylor, Ian A., Stoye, Jonathan P.

“…SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate. In…”
Get full text

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction: e1005194 by Arnold, Laurence H, Groom, Harriet CT, Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J, Ordonez, Paula, Mann, Melanie C, Rueschenbaum, Sabrina, Goldstone, David C, Pennell, Simon, Howell, Steven A, Stoye, Jonathan P, Webb, Michelle, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase…”
Get full text