Search Results - "Gronemeyer, Hinrich"

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells by Shlyakhtina, Yelyzaveta, Pavet, Valeria, Gronemeyer, Hinrich

“…Besides its tumor-selective apoptotic activity, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes pro-survival, proliferative or…”
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Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids by Álvarez, Rosana, Vaz, Belén, Gronemeyer, Hinrich, de Lera, Ángel R

“…Alvarez et al investigated the functions, synthesis and uses of retinoids and carotenoids and detail how the knowledge gleaned from this research is being used…”
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Modulation of RXR function through ligand design by Pérez, Efrén, Bourguet, William, Gronemeyer, Hinrich, de Lera, Angel R.

“…As the promiscuous partner of heterodimeric associations, retinoid X receptors (RXRs) play a key role within the Nuclear Receptor (NR) superfamily. Some of the…”
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RAR and RXR modulation in cancer and metabolic disease by Gronemeyer, Hinrich, Altucci, Lucia, Leibowitz, Mark D, Ogilvie, Kathleen M, de Lera, Angel R

“…Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell…”
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The promise of retinoids to fight against cancer by Altucci, Lucia, Gronemeyer, Hinrich

“…Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive capacity. Cell biology and…”
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Design of selective nuclear receptor modulators: RAR and RXR as a case study by Gronemeyer, Hinrich, de Lera, Angel R, Bourguet, William, Altucci, Lucia

“…Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are members of the nuclear receptor superfamily whose effects on cell growth and survival can be…”
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The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer by Chaligné, Ronan, Popova, Tatiana, Mendoza-Parra, Marco-Antonio, Saleem, Mohamed-Ashick M, Gentien, David, Ban, Kristen, Piolot, Tristan, Leroy, Olivier, Mariani, Odette, Gronemeyer, Hinrich, Vincent-Salomon, Anne, Stern, Marc-Henri, Heard, Edith

“…Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and…”
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International Union of Pharmacology. LXIII. Retinoid X Receptors by Germain, Pierre, Chambon, Pierre, Eichele, Gregor, Evans, Ronald M, Lazar, Mitchell A, Leid, Mark, De Lera, Angel R, Lotan, Reuben, Mangelsdorf, David J, Gronemeyer, Hinrich

“…The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the…”
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The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation by Brier, Ann-Sofie B, Loft, Anne, Madsen, Jesper G S, Rosengren, Thomas, Nielsen, Ronni, Schmidt, Søren F, Liu, Zongzhi, Yan, Qin, Gronemeyer, Hinrich, Mandrup, Susanne

“…The KDM5 family of histone demethylases removes the H3K4 tri-methylation (H3K4me3) mark frequently found at promoter regions of actively transcribed genes and…”
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International Union of Pharmacology. LX. Retinoic Acid Receptors by Germain, Pierre, Chambon, Pierre, Eichele, Gregor, Evans, Ronald M, Lazar, Mitchell A, Leid, Mark, De Lera, Angel R, Lotan, Reuben, Mangelsdorf, David J, Gronemeyer, Hinrich

“…Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor…”
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Dissecting the retinoid‐induced differentiation of F9 embryonal stem cells by integrative genomics by Mendoza‐Parra, Marco A, Walia, Mannu, Sankar, Martial, Gronemeyer, Hinrich

“…Retinoic acid (RA) triggers physiological processes by activating heterodimeric transcription factors (TFs) comprising retinoic acid receptor (RARα, β, γ) and…”
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Single-tube linear DNA amplification (LinDA) for robust ChIP-seq by Shankaranarayanan, Pattabhiraman, Mendoza-Parra, Marco-Antonio, Walia, Mannu, Wang, Li, Li, Ning, Trindade, Luisa M, Gronemeyer, Hinrich

“…A linear, one-tube amplification procedure generates sufficient amounts of material from chromatin immunoprecipitation (ChIP) and reChIP experiments to allow…”
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The nuclear receptor ligand-binding domain: structure and function by Moras, Dino, Gronemeyer, Hinrich

“…In the past few years our understanding of nuclear receptor action has dramatically improved as a result of the elucidation of the crystal structures of the…”
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Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function by Fujii, Shinya, Mori, Shuichi, Kagechika, Hiroyuki, Mendoza Parra, Marco Antonio, Gronemeyer, Hinrich

“…[Display omitted] •Conjugate molecules of retinoid (Am580) and biotin were designed and synthesized.•One of the synthesized conjugates retained biological…”
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Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications by Bourguet, William, Germain, Pierre, Gronemeyer, Hinrich

“…Nuclear receptors are members of a large family of ligand-inducible transcription factors that regulate gene programs underlying a plethora of…”
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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells by Gronemeyer, Hinrich, Altucci, Lucia, Nebbioso, Angela, Clarke, Nicole, Voltz, Emilie, Germain, Emmanuelle, Ambrosino, Concetta, Bontempo, Paola, Alvarez, Rosana, Schiavone, Ettore M, Ferrara, Felicetto, Bresciani, Francesco, Weisz, Alessandro, de Lera, Angel R

“…Chromatin is a dynamic macromolecular structure epigenetically modified to regulate specific gene expression. Altered chromatin function can lead to aberrant…”
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Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes by Nebbioso, Angela, Manzo, Fabio, Miceli, Marco, Conte, Mariarosaria, Manente, Lucrezia, Baldi, Alfonso, De Luca, Antonio, Rotili, Dante, Valente, Sergio, Mai, Antonello, Usiello, Alessandro, Gronemeyer, Hinrich, Altucci, Lucia

“…Histone deacetylase (HDAC) inhibitors are promising new epi‐drugs, but the presence of both class I and class II enzymes in HDAC complexes precludes a detailed…”
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A quality control system for profiles obtained by ChIP sequencing by Mendoza-Parra, Marco-Antonio, Van Gool, Wouter, Mohamed Saleem, Mohamed Ashick, Ceschin, Danilo Guillermo, Gronemeyer, Hinrich

“…The absence of a quality control (QC) system is a major weakness for the comparative analysis of genome-wide profiles generated by next-generation sequencing…”
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Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity by PAVET, Valeria, BEYRATH, Julien, GUICHARD, Gilles, GRONEMEYER, Hinrich, PARDIN, Christophe, MORIZOT, Alexandre, LECHNER, Marie-Charlotte, BRIAND, Jean-Paul, WENDLAND, Miriam, MAISON, Wolfgang, FOURNEL, Sylvie, MICHEAU, Olivier

“…Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we…”
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Reconstructed cell fate-regulatory programs in stem cells reveal hierarchies and key factors of neurogenesis by Mendoza-Parra, Marco-Antonio, Malysheva, Valeriya, Mohamed Saleem, Mohamed Ashick, Lieb, Michele, Godel, Aurelie, Gronemeyer, Hinrich

“…Cell lineages, which shape the body architecture and specify cell functions, derive from the integration of a plethora of cell intrinsic and extrinsic signals…”
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