Search Results - "Groneberg, Robert D"

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor by Bach, Peter, Boström, Jonas, Brickmann, Kay, van Giezen, J.J.J., Groneberg, Robert D., Harvey, Darren M., O'Sullivan, Michael, Zetterberg, Fredrik

“…The present paper describes the development of a new series of P2Y12 receptor antagonists based on our previously reported piperazinyl urea series 1 (IC50…”
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Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors by Eary, C. Todd, Jones, Zachary S., Groneberg, Robert D., Burgess, Laurence E., Mareska, David A., Drew, Mark D., Blake, James F., Laird, Ellen R., Balachari, Devan, O’Sullivan, Michael, Allen, Andrew, Marsh, Vivienne

“…The SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors is described from early lead to advanced analogs. Cholesteryl ester…”
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5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor by Bach, Peter, Boström, Jonas, Brickmann, Kay, Burgess, Laurence E, Clarke, David, Groneberg, Robert D, Harvey, Darren M, Laird, Ellen R, O'Sullivan, Michael, Zetterberg, Fredrik

“…Recently, we reported ethyl nicotinates as antagonists of the P2Y12 receptor, which is an important target in antiplatelet therapies. A potential liability of…”
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Identification of a Nonpeptidic and Conformationally Restricted Bradykinin B1 Receptor Antagonist with Anti-Inflammatory Activity by D'Amico, Derin C, Aya, Toshi, Human, Jason, Fotsch, Christopher, Chen, Jian Jeffrey, Biswas, Kaustav, Riahi, Bobby, Norman, Mark H, Willoughby, Christopher A, Hungate, Randall, Reider, Paul J, Biddlecome, Gloria, Lester-Zeiner, Dianna, Van Staden, Carlo, Johnson, Eileen, Kamassah, Augustus, Arik, Leyla, Wang, Judy, Viswanadhan, Vellarkad N, Groneberg, Robert D, Zhan, James, Suzuki, Hideo, Toro, Andras, Mareska, David A, Clarke, David E, Harvey, Darren M, Burgess, Laurence E, Laird, Ellen R, Askew, Benny, Ng, Gordon

“…We report the discovery of chroman 28, a potent and selective antagonist of human, nonhuman primate, rat, and rabbit bradykinin B1 receptors (0.4−17 nM). At 90…”
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Potent Nonpeptide Antagonists of the Bradykinin B1 Receptor:  Structure−Activity Relationship Studies with Novel Diaminochroman Carboxamides by Biswas, Kaustav, Li, Aiwen, Chen, Jian Jeffrey, D'Amico, Derin C, Fotsch, Christopher, Han, Nianhe, Human, Jason, Liu, Qingyian, Norman, Mark H, Riahi, Bobby, Yuan, Chester, Suzuki, Hideo, Mareska, David A, Zhan, James, Clarke, David E, Toro, Andras, Groneberg, Robert D, Burgess, Laurence E, Lester-Zeiner, Dianna, Biddlecome, Gloria, Manning, Barton H, Arik, Leyla, Dong, Hong, Huang, Ming, Kamassah, Augustus, Loeloff, Richard, Sun, Hong, Hsieh, Feng-Yin, Kumar, Gondi, Ng, Gordon Y, Hungate, Randall W, Askew, Benny C, Johnson, Eileen

“…The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for…”
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Nanomolar Inhibitors for Two Distinct Biological Target Families from a Single Synthetic Sequence: A Next Step in Combinatorial Library Design? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

“…One common synthetic route creates small‐molecule libraries directed toward two functionally distinct target families. The novel structural template 1 can…”
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A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core by Fotsch, Christopher, Biddlecome, Gloria, Biswas, Kaustav, Chen, Jian Jeff, D’Amico, Derin C., Groneberg, Robert D., Han, Nianhe Bruce, Hsieh, Feng-Yin, Kamassah, Augustus, Kumar, Gondi, Lester-Zeiner, Dianna, Liu, Qingyian, Mareska, David A., Riahi, Babak Bobby, Wang, Yueh-Ju Judy, Yang, Kevin, Zhan, James, Zhu, Joe, Johnson, Eileen, Ng, Gordon, Askew, Benny C.

“…Compound 1 was an early lead in our bradykinin 1 receptor antagonist program. By adding two conformational constraints to this compound and by exploring the…”
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Novel strategy for the construction of the oligosaccharide fragment of calichemicin .gamma.1.alpha.I. Synthesis of the ABC skeleton by Nicolaou, K. C, Groneberg, Robert D

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Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template by Groneberg, Robert D, Burns, Christopher J, Morrissette, Matthew M, Ullrich, John W, Morris, Robert L, Darnbrough, Shelley, Djuric, Stevan W, Condon, Stephen M, McGeehan, Gerard M, Labaudiniere, Richard, Neuenschwander, Kent, Scotese, Anthony C, Kline, Jane A

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Total synthesis of the oligosaccharide fragment of calicheamicin .gamma.1I by Nicolaou, K. C, Groneberg, Robert D, Miyazaki, T, Stylianides, N. A, Schulze, T. J, Stahl, W

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Novel strategy for the construction of the oligosaccharide fragment of calicheamicin γ1α synthesis of the ABC skeleton by NICOLAOU, K. C, GRONEBERG, R. D

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Synthesis of the calicheamicin gamma(1)(I) oligosaccharide by Groneberg, Robert D

“…The calicheamicin $\gamma\sb1\sp{\rm I}$ oligosaccharide represents one of the most complex and unique carbohydrates to be isolated to date. Thus, its…”
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Synthese von Inhibitoren für zwei Familien biologischer Targets in einer Sequenz: ein nächster Schritt beim Aufbau kombinatorischer Bibliotheken? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

“…Über nureinen Syntheseweg lassen sich Bibliotheken aus niedermolekularen Verbindungen aufbauen, die auf zwei Targetfamilien mit unterschiedlichen…”
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Synthese von Inhibitoren für zwei Familien biologischer Targets in einer Sequenz: ein nächster Schritt beim Aufbau kombinatorischer Bibliotheken? by Burns, Christopher J., Groneberg, Robert D., Salvino, Joseph M., McGeehan, Gerard, Condon, Stephen M., Morris, Robert, Morrissette, Matthew, Mathew, Rose, Darnbrough, Shelley, Neuenschwander, Kent, Scotese, Anthony, Djuric, Stevan W., Ullrich, John, Labaudiniere, Richard

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