Search Results - "Grondona, Jesús M."

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis by Fernández-Arjona, María Del Mar, Grondona, Jesús M, Granados-Durán, Pablo, Fernández-Llebrez, Pedro, López-Ávalos, María D

“…It is known that microglia morphology and function are closely related, but only few studies have objectively described different morphological subtypes. To…”
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Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors by Fernández-Arjona, María Del Mar, Grondona, Jesús M, Fernández-Llebrez, Pedro, López-Ávalos, María Dolores

“…Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved…”
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Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes by Fernández-Arjona, María del Mar, Grondona, Jesús M., Fernández-Llebrez, Pedro, López-Ávalos, María D.

“…Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia have been described: one considered as a resting/surveillant state…”
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Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase by León-Rodríguez, Ana, Fernández-Arjona, María del Mar, Grondona, Jesús M., Pedraza, Carmen, López-Ávalos, María D.

“…Short-term behavioral alterations are associated with infection and aid the recovery from sickness. However, concerns have raised that sustained behavioral…”
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Long-term reprogramming of primed microglia after moderate inhibition of CSF1R signaling by León-Rodríguez, Ana, Grondona, Jesús M, Marín-Wong, Sonia, López-Aranda, Manuel F, López-Ávalos, María D

“…In acute neuroinflammation, microglia activate transiently, and return to a resting state later on. However, they may retain immune memory of such event,…”
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Long‐term priming of hypothalamic microglia is associated with energy balance disturbances under diet‐induced obesity by Fernández‐Arjona, María del Mar, León‐Rodríguez, Ana, Grondona, Jesús M., López‐Ávalos, María D.

“…Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to…”
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Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus by Rivera, Patricia, Pérez-Martín, Margarita, Pavón, Francisco J, Serrano, Antonia, Crespillo, Ana, Cifuentes, Manuel, López-Ávalos, María-Dolores, Grondona, Jesús M, Vida, Margarita, Fernández-Llebrez, Pedro, de Fonseca, Fernando Rodríguez, Suárez, Juan

“…Soy extracts have been claimed to be neuroprotective against brain insults, an effect related to the estrogenic properties of isoflavones. However, the effects…”
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Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure by Rivera, Patricia, Fernández-Arjona, María del Mar, Silva-Peña, Daniel, Blanco, Eduardo, Vargas, Antonio, López-Ávalos, María Dolores, Grondona, Jesús M., Serrano, Antonia, Pavón, Francisco Javier, Rodríguez de Fonseca, Fernando, Suárez, Juan

“…[Display omitted] Changes in endogenous cannabinoid homeostasis are associated with both ethanol-related neuroinflammation and memory decline. Extensive…”
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Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain by Fernández-Arjona, María del Mar, León-Rodríguez, Ana, Grondona, Jesús M., López-Ávalos, María Dolores

“…Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses…”
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Microglia activated by microbial neuraminidase contributes to ependymal cell death by Fernández-Arjona, María Del Mar, León-Rodríguez, Ana, López-Ávalos, María Dolores, Grondona, Jesús M

“…The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal…”
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Complement system activation contributes to the ependymal damage induced by microbial neuraminidase by Granados-Durán, Pablo, López-Ávalos, María Dolores, Hughes, Timothy R, Johnson, Krista, Morgan, B Paul, Tamburini, Paul P, Fernández-Llebrez, Pedro, Grondona, Jesús M

“…In the rat brain, a single intracerebroventricular injection of neuraminidase from Clostridium perfringens induces ependymal detachment and death. This injury…”
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Diet-dependent modulation of hippocampal expression of endocannabinoid signaling-related proteins in cannabinoid antagonist-treated obese rats by Rivera, Patricia, Luque-Rojas, María Jesús, Pastor, Antoni, Blanco, Eduardo, Pavón, Francisco J., Serrano, Antonia, Crespillo, Ana, Vida, Margarita, Grondona, Jesús M., Cifuentes, Manuel, Bermúdez-Silva, Francisco J., de la Torre, Rafael, de Fonseca, Fernando Rodríguez, Suárez, Juan

“…Diet‐induced obesity produces changes in endocannabinoid signaling (ECS), influencing the regulation of energy homeostasis. Recently, we demonstrated that, in…”
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Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca2+-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus by Rivera, Patricia, Arrabal, Sergio, Cifuentes, Manuel, Grondona, Jesús M., Pérez-Martín, Margarita, Rubio, Leticia, Vargas, Antonio, Serrano, Antonia, Pavón, Francisco J., Suárez, Juan, Rodríguez de Fonseca, Fernando

“…The retrograde suppression of the synaptic transmission by the endocannabinoid sn-2-arachidonoylglycerol (2-AG) is mediated by the cannabinoid CB1 receptors…”
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Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation by Granados-Durán, Pablo, López-Ávalos, María Dolores, Cifuentes, Manuel, Pérez-Martín, Margarita, Fernández-Arjona, María Del Mar, Hughes, Timothy R, Johnson, Krista, Morgan, B Paul, Fernández-Llebrez, Pedro, Grondona, Jesús M

“…Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA…”
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The Subcommissural Organ and the Development of the Posterior Commissure by Grondona, Jesús M., Hoyo-Becerra, Carolina, Visser, Rick, Fernández-Llebrez, Pedro, López-Ávalos, María Dolores

“…Growing axons navigate through the developing brain by means of axon guidance molecules. Intermediate targets producing such signal molecules are used as…”
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Neuroinflammation induced by intracerebroventricular injection of microbial neuraminidase by Granados-Durán, Pablo, López-Ávalos, María D, Grondona, Jesús M, Gómez-Roldán, María Del Carmen, Cifuentes, Manuel, Pérez-Martín, Margarita, Alvarez, Martina, Rodríguez de Fonseca, Fernando, Fernández-Llebrez, Pedro

“…In the present paper, we describe the facts that took place in the rat brain after a single injection of the enzyme neuraminidase from Clostridium perfringens…”
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Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus by Rivera, Patricia, Arrabal, Sergio, Cifuentes, Manuel, Grondona, Jesús M, Pérez-Martín, Margarita, Rubio, Leticia, Vargas, Antonio, Serrano, Antonia, Pavón, Francisco J, Suárez, Juan, Rodríguez de Fonseca, Fernando

“…The retrograde suppression of the synaptic transmission by the endocannabinoid sn-2-arachidonoylglycerol (2-AG) is mediated by the cannabinoid CB1 receptors…”
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The central nervous system of sea cucumbers (Echinodermata: Holothuroidea) shows positive immunostaining for a chordate glial secretion by Mashanov, Vladimir S, Zueva, Olga R, Heinzeller, Thomas, Aschauer, Beate, Naumann, Wilfried W, Grondona, Jesus M, Cifuentes, Manuel, Garcia-Arraras, Jose E

“…Echinoderms and chordates belong to the same monophyletic taxon, the Deuterostomia. In spite of significant differences in body plan organization, the two…”
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Retinal dysplasia and degeneration in RARβ2/RARγ2 compound mutant mice by Grondona, Jesús M., Kastner, Philippe, Gansmuller, Anne, Décimo, Didier, Chambon, Pierre, Mark, Manuel

“…The eye is the organ whose development is the most frequently altered in response to maternal vitamin A deficiency [VAD; Warkany, J. and Schraffenberger, S…”
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subcommissural organ and the development of the posterior commissure in chick embryos by Hoyo-Becerra, Carolina, López-Ávalos, Maria Dolores, Cifuentes, Manuel, Visser, Rick, Fernández-Llebrez, Pedro, Grondona, Jesus M

“…The subcommissural organ (SCO) is an ependymal differentiation located in the diencephalon under the posterior commissure (PC). SCO-spondin, a glycoprotein…”
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