Search Results - "Grollman, F."

Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE by Philp, N J, Yoon, H, Grollman, E F

“…The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier and regulates the movement of nutrients, water, and ions between the choroidal blood…”
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Determination of Transport Kinetics of Chick MCT3 Monocarboxylate Transporter from Retinal Pigment Epithelium by Expression in Genetically Modified Yeast by Grollman, Evelyn F, Philp, Nancy J, McPhie, Peter, Ward, Rita D, Sauer, Brian

“…Monocarboxylate transporters (MCTs) comprise a group of highly homologous proteins that reside in the plasma membrane of almost all cells and which mediate the…”
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Identification of a Unique Monocarboxylate Transporter (MCT3) in Retinal Pigment Epithelium by Yoon, Heeyong, Fanelli, Albertina, Grollman, Evelyn F., Philp, Nancy J.

“…The retinal pigment epithelium transports lactate between two tissue compartments, the interphotoreceptor matrix and the choriocapillaris. In this report we…”
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MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells by Fanelli, Albertina, Grollman, Evelyn F, Wang, Dian, Philp, Nancy J

“…In thyroid cells, basal and TSH-stimulated glycolysis is associated with lactic acid efflux. In this report, we address whether monocarboxylate transporters…”
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Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients by Dahut, W, Harold, N, Takimoto, C, Allegra, C, Chen, A, Hamilton, J M, Arbuck, S, Sorensen, M, Grollman, F, Nakashima, H, Lieberman, R, Liang, M, Corse, W, Grem, J

“…To conduct a phase I and pharmacologic study of the new topoisomerase I inhibitor, 9-aminocamptothecin (9-AC). A 72-hour infusion of 9-AC was administered…”
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Iodide transport in a continuous line of cultured cells from rat thyroid by Weiss, S J, Philp, N J, Grollman, E F

“…The properties of TSH-dependent iodide (I-) uptake are defined for a cloned, continuously growing, functioning rat thyroid cell line (FRTL-5 cells). Since…”
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A TSH/Dibutyryl cAMP Activated Cl−/I− Channel in FRTL-5 Cells by Yoshida, Akio, Hattori, Kimihiko, Hisatome, Ichiro, Taniguchi, Shinichi, Ueta, Yoshihiko, Hukui, Hiroko, Santo, Yuka, Igawa, Osamu, Shigemasa, Chiaki, Kosugi, Shinji, Grollman, Evelyn F.

“…An iodide (I) and chloride (Cl) channel has been identified in the continuously cultured FRTL-5 thyroid cell line using a cell attached patch clamp technique…”
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Thyrotropin-stimulated iodide transport mediated by adenosine 3',5'-monophosphate and dependent on protein synthesis by Weiss, S J, Philp, N J, Ambesi-Impiombato, F S, Grollman, E F

“…Iodide (I-) uptake by FRTL-5 cells, a functioning rat thyroid cell line, is TSH dependent. The effects of TSH withdrawal are not apparent until 1 day; 1 week…”
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Regulation of prostaglandin synthesis by thyrotropin, insulin or insulin-like growth factor-I, and serum in FRTL-5 rat thyroid cells by Tahara, K, Grollman, E F, Saji, M, Kohn, L D

“…The present report shows that thyrotropin (TSH) regulates all three steps involved in prostaglandin synthesis in FRTL-5 rat thyroid cells, i.e. arachidonic…”
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Thyrotropin regulation of sialic acid expression in rat thyroid cells by GROLLMAN, E. F, SAJI, M, SHIMURA, Y, LAU, J. T. Y, ASHWELL, G

“…The present study, utilizing the hormone-responsive rat thyroid cell line FRTL-5, presents evidence establishing the regulatory role of thyrotropin in…”
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N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma by Grem, J. L., Yee, L. K., Schuler, B., Hamilton, J. M., Chen, A. P., Chabuk, C., Grollman, F., Grabenc, M., Allegra, C. J., Takimoto, C. H.

“…Summary Background- We have reported that N-(phosphonacetyl)-L-aspartic acid (PALA) 1266 mg/m2 can safely be given 24 hours prior to the start of a 72-hour…”
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Hyposialylated thyroglobulin in a patient with congenital goiter and hypothyroidism by Grollman, E F, Doi, S Q, Weiss, P, Ashwell, G, Wajchenberg, B L, Medeiros-Neto, G

“…A large family (14 children) with congenital goiter whose parents are first cousins was studied. Thyroid tissue was obtained, after 125I in vivo labeling, from…”
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Norepinephrine and thyroid-stimulating hormone induce inositol phosphate accumulation in FRTL-5 cells by Bone, E A, Alling, D W, Grollman, E F

“…3H-Labeled inositol phosphate accumulation is observed when prelabeled FRTL-5 cells (a rat thyroid cell line) are exposed to norepinephrine (NE) or TSH. The…”
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Norepinephrine and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of arachidonic acid and is associated with the iodination of thyroglobulin by Marcocci, C, Luini, A, Santisteban, P, Grollman, E F

“…Ca2+-dependent and TSH-, norepinephrine (NE)-, and A23187-induced iodide (I-) efflux from FRTL-5 rat thyroid cells is inhibited by quinacrine and…”
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Phase I and Pharmacologic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients With Solid Tumors by GREM, Jean L, MORRISON, Geraldine, NECKERS, Len, WILSON, Richard H, GUO, Xiao-Du, AGNEW, Elizabeth, TAKIMOTO, Chris H, THOMAS, Rebecca, SZABO, Eva, GROCHOW, Louise, GROLLMAN, Frank, HAMILTON, J. Michael

“…To determine the clinical toxicities of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) given as a 1-hour infusion daily for 5 days every 3 weeks. Nineteen…”
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Antibodies that promote thyroid growth. A distinct population of thyroid-stimulating autoantibodies by Valente, W A, Vitti, P, Rotella, C M, Vaughan, M M, Aloj, S M, Grollman, E F, Ambesi-Impiombato, F S, Kohn, L D

“…We used a strain of differentiated rat-thyroid cells in continuous culture (the FRTL-5 strain) to detect the presence of growth-promoting antibodies in serum…”
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Monoclonal Antibodies to the Thyrotropin Receptor: Stimulating and Blocking Antibodies Derived from the Lymphocytes of Patients with Graves Disease by Valente, William A., Vitti, Paolo, Yavin, Ziva, Yavin, Ephraim, Rotella, Carlo M., Grollman, Evelyn F., Toccafondi, Roberto S., Kohn, Leonard D.

“…Human monoclonal antibodies have been generated from heterohybridomas obtained by fusing mouse myeloma cells with peripheral lymphocytes from patients with…”
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Calcium transport mechanisms in membrane vesicles from guinea pig brain synaptosomes by Gill, D L, Grollman, E F, Kohn, L D

“…Ca2+ transport mechanisms were investigated using membrane vesicles prepared from guinea pig brain synaptosomes by hypotonic lysis. Two major mechanisms of…”
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Characteristics of a lysosomal membrane transport system for tyrosine and other neutral amino acids in rat thyroid cells by Bernar, J, Tietze, F, Kohn, L D, Bernardini, I, Harper, G S, Grollman, E F, Gahl, W A

“…Tyrosine countertransport was used to demonstrate the existence of a carrier system for neutral amino acids in the lysosomal membrane of FRTL-5 thyroid cells…”
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Characterization of the optimal stimulatory effects of graves' monoclonal and serum immunoglobulin G on adenosine 3',5'-monophosphate production in fRTL-5 thyroid cells: a potential clinical assay by Vitti, P, Rotella, C M, Valente, W A, Cohen, J, Aloj, S M, Laccetti, P, Ambesi-Impiombato, F S, Grollman, E F, Pinchera, A, Toccafondi, R, Kohn, L D

“…Immunoglobulin G (IgG) preparations derived from the sera of patients with hyperthyroidism due to Graves' disease (TSAb) as well as a monoclonal IgG derived…”
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