Search Results - "Grollman, Arthur"

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease by Grollman, Arthur P.

“…This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper…”
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Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing by Hoang, Margaret L., Kinde, Isaac, Tomasetti, Cristian, McMahon, K. Wyatt, Rosenquist, Thomas A., Grollman, Arthur P., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas

“…We present the bottleneck sequencing system (BotSeqS), a next-generation sequencing method that simultaneously quantifies rare somatic point mutations across…”
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Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC) by Soria, Francesco, Shariat, Shahrokh F., Lerner, Seth P., Fritsche, Hans-Martin, Rink, Michael, Kassouf, Wassim, Spiess, Philippe E., Lotan, Yair, Ye, Dingwei, Fernández, Mario I., Kikuchi, Eiji, Chade, Daher C., Babjuk, Marko, Grollman, Arthur P., Thalmann, George N.

“…Purpose Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this…”
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Aristolochic acid-associated urothelial cancer in Taiwan by Chen, Chung-Hsin, Dickman, Kathleen G, Moriya, Masaaki, Zavadil, Jiri, Sidorenko, Viktoriya S, Edwards, Karen L, Gnatenko, Dmitri V, Wu, Lin, Turesky, Robert J, Wu, Xue-Ru, Pu, Yeong-Shiau, Grollman, Arthur P

“…Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC)…”
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Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature by Hassler, Melanie R., Bray, Freddie, Catto, James W.F., Grollman, Arthur P., Hartmann, Arndt, Margulis, Vitaly, Matin, Surena F., Roupret, Morgan, Sfakianos, John P., Shariat, Shahrokh F., Faltas, Bishoy M.

“…While upper tract urothelial carcinoma (UTUC) share histological appearance with bladder cancer (BC), the former has differences in etiology and clinical…”
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Mutational signature of aristolochic acid: Clue to the recognition of a global disease by Rosenquist, Thomas A., Grollman, Arthur P.

“…Mutational signatures associated with specific forms of DNA damage have been identified in several forms of human cancer. Such signatures provide information…”
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Role of environmental toxins in endemic (balkan) nephropathy by GROLLMAN, Arthur P, JELAKOVIC, Bojan

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Global hazards of herbal remedies: lessons from Aristolochia: The lesson from the health hazards of Aristolochia should lead to more research into the safety and efficacy of medicinal plants by Grollman, Arthur P, Marcus, Donald M

“…Graphical Abstract It took years of epidemiological and molecular research to demonstrate that Aristolochia , a widely used herbal remedy, causes cancer and…”
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Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing by Hoang, Margaret L, Chen, Chung-Hsin, Sidorenko, Viktoriya S, He, Jian, Dickman, Kathleen G, Yun, Byeong Hwa, Moriya, Masaaki, Niknafs, Noushin, Douville, Christopher, Karchin, Rachel, Turesky, Robert J, Pu, Yeong-Shiau, Vogelstein, Bert, Papadopoulos, Nickolas, Grollman, Arthur P, Kinzler, Kenneth W, Rosenquist, Thomas A

“…In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19…”
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Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy by Springer, Simeon U, Chen, Chung-Hsin, Rodriguez Pena, Maria Del Carmen, Li, Lu, Douville, Christopher, Wang, Yuxuan, Cohen, Joshua David, Taheri, Diana, Silliman, Natalie, Schaefer, Joy, Ptak, Janine, Dobbyn, Lisa, Papoli, Maria, Kinde, Isaac, Afsari, Bahman, Tregnago, Aline C, Bezerra, Stephania M, VandenBussche, Christopher, Fujita, Kazutoshi, Ertoy, Dilek, Cunha, Isabela W, Yu, Lijia, Bivalacqua, Trinity J, Grollman, Arthur P, Diaz, Luis A, Karchin, Rachel, Danilova, Ludmila, Huang, Chao-Yuan, Shun, Chia-Tung, Turesky, Robert J, Yun, Byeong Hwa, Rosenquist, Thomas A, Pu, Yeong-Shiau, Hruban, Ralph H, Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Ken W, Vogelstein, Bert, Dickman, Kathleen G, Netto, George J

“…Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from…”
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Is there a role for botanical medicines in the twenty‐first century?: Promotion of untested traditional therapies by the World Health Organization and China endangers global public health by Grollman, Arthur P, Marcus, Donald M

“…Graphical Abstract China and the WHO's promotion of herbal and traditional medicines, most of which were not tested for safety and efficacy, have raised public…”
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Aristolochia Herbs and Iatrogenic Disease: The Case of Portland's Powders by Tomlinson, Tristan, Fernandes, Andrea, Grollman, Arthur P

“…herbals have a 2500-year history of medicinal use. We focused this article on Portland's Powders, an 18 -century British gout medicine containing herbs. The…”
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal by Killela, Patrick J., Reitman, Zachary J., Jiao, Yuchen, Bettegowda, Chetan, Agrawal, Nishant, Diaz, Luis A., Friedman, Allan H., Friedman, Henry, Gallia, Gary L., Giovanella, Beppino C., Grollman, Arthur P., He, Tong-Chuan, He, Yiping, Hruban, Ralph H., Jallo, George I., Mandahl, Nils, Meeker, Alan K., Mertens, Fredrik, Netto, George J., Rasheed, B. Ahmed, Riggins, Gregory J., Rosenquist, Thomas A., Schiffman, Mark, Shih, Ie-Ming, Theodorescu, Dan, Torbenson, Michael S., Velculescu, Victor E., Wang, Tian-Li, Wentzensen, Nicolas, Wood, Laura D., Zhang, Ming, McLendon, Roger E., Bigner, Darell D., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Yan, Hai

“…Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have…”
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Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation by Romanov, Victor, Whyard, Terry C., Waltzer, Wayne C., Grollman, Arthur P., Rosenquist, Thomas

“…Ingestion of aristolochic acids (AAs) contained in herbal remedies results in a renal disease and, frequently, urothelial malignancy. The genotoxicity of AA in…”
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Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid by Jelaković, Bojan, Karanović, Sandra, Vuković-Lela, Ivana, Miller, Frederick, Edwards, Karen L, Nikolić, Jovan, Tomić, Karla, Slade, Neda, Brdar, Branko, Turesky, Robert J, Stipančić, Želimir, Dittrich, Damir, Grollman, Arthur P, Dickman, Kathleen G

“…Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently accompanied by urothelial cell carcinomas of the upper urinary tract. This…”
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Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review by Dickman, Kathleen G., Chen, Chung-Hsin, Grollman, Arthur P., Pu, Yeong-Shiau

“…Purpose The high incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan is largely due to exposure to aristolochic acid (AA), a principal…”
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Aristolochic Acid in the Etiology of Renal Cell Carcinoma by Hoang, Margaret L, Chen, Chung-Hsin, Chen, Pau-Chung, Roberts, Nicholas J, Dickman, Kathleen G, Yun, Byeong Hwa, Turesky, Robert J, Pu, Yeong-Shiau, Vogelstein, Bert, Papadopoulos, Nickolas, Grollman, Arthur P, Kinzler, Kenneth W, Rosenquist, Thomas A

“…Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human carcinogen contributing to…”
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Aristolochic acid and the etiology of endemic (Balkan) nephropathy by Grollman, Arthur P, Shibutani, Shinya, Moriya, Masaaki, Miller, Frederick, Wu, Lin, Moll, Ute, Suzuki, Naomi, Fernandes, Andrea, Rosenquist, Thomas, Medverec, Zvonimir, Jakovina, Krunoslav, Brdar, Branko, Slade, Neda, Turesky, Robert J, Goodenough, Angela K, Rieger, Robert, Vukelić, Mato, Jelaković, Bojan

“…Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia,…”
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Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin by Pomyalov, Sergei, Minetti, Conceição A., Remeta, David P., Bonala, Radha, Johnson, Francis, Zaitseva, Irina, Iden, Charles, Golebiewska, Urszula, Breslauer, Kenneth J., Shoham, Gil, Sidorenko, Viktoriya S., Grollman, Arthur P.

“…Aristolochic acids I and II (AA-I/II) are carcinogenic principles of Aristolochia plants, which have been employed in traditional medicinal practices and…”
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Aristolochic acid‐induced upper tract urothelial carcinoma in Taiwan: Clinical characteristics and outcomes by Chen, Chung‐Hsin, Dickman, Kathleen G., Huang, Chao‐Yuan, Moriya, Masaaki, Shun, Chia‐Tung, Tai, Huai‐Ching, Huang, Kuo‐How, Wang, Shuo‐Meng, Lee, Yuan‐Ju, Grollman, Arthur P., Pu, Yeong‐Shiau

“…Aristolochic acid (AA), a component of all Aristolochia‐based herbal medicines, is a potent nephrotoxin and human carcinogen associated with upper urinary…”
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