Search Results - "Grolleman, Judith"

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer by Drost, Jarno, van Boxtel, Ruben, Blokzijl, Francis, Mizutani, Tomohiro, Sasaki, Nobuo, Sasselli, Valentina, de Ligt, Joep, Behjati, Sam, Grolleman, Judith E., van Wezel, Tom, Nik-Zainal, Serena, Kuiper, Roland P., Cuppen, Edwin, Clevers, Hans

“…Mutational processes underlie cancer initiation and progression. Signatures of these processes in cancer genomes may explain cancer etiology and could hold…”
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Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer by Elsayed, Fadwa A., Grolleman, Judith E., Ragunathan, Abiramy, Boot, Arnoud, Stojovska, Marija Staninova, Mahmood, Khalid, Clendenning, Mark, de Miranda, Noel, Dymerska, Dagmara, Egmond, Demi van, Gallinger, Steven, Georgeson, Peter, Hoogerbrugge, Nicoline, Hopper, John L., Jansen, Erik A.M., Jenkins, Mark A., Joo, Jihoon E., Kuiper, Roland P., Ligtenberg, Marjolijn J.L., Lubinski, Jan, Macrae, Finlay A., Morreau, Hans, Newcomb, Polly, Nielsen, Maartje, Palles, Claire, Park, Daniel J., Pope, Bernard J., Rosty, Christophe, Ruiz Ponte, Clara, Schackert, Hans K., Sijmons, Rolf H., Tomlinson, Ian P., Tops, Carli M.J., Vreede, Lilian, Walker, Romy, Win, Aung K., Buchanan, Daniel D., van Wezel, Tom, de Voer, Richarda M.

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Somatic mutational signatures in polyposis and colorectal cancer by Grolleman, Judith E., Díaz-Gay, Marcos, Franch-Expósito, Sebastià, Castellví-Bel, Sergi, de Voer, Richarda M.

“…The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing…”
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The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans by Maxeiner, Sabrina, Grolleman, Judith, Schmid, Tobias, Kammenga, Jan, Hajnal, Alex

“…Animals need to adjust many cellular functions to oxygen availability to adapt to changing environmental conditions. We have used the nematode as a model to…”
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Contribution of New Adenomatous Polyposis Predisposition Genes in an Unexplained Attenuated Spanish Cohort by Multigene Panel Testing by Lorca, Víctor, Rueda, Daniel, Martín-Morales, Lorena, Fernández-Aceñero, María Jesús, Grolleman, Judith, Poves, Carmen, Llovet, Patricia, Tapial, Sandra, García-Barberán, Vanesa, Sanz, Julián, Pérez-Segura, Pedro, de Voer, Richarda M., Díaz-Rubio, Eduardo, de la Hoya, Miguel, Caldés, Trinidad, Garre, Pilar

“…Attenuated adenomatous polyposis (AAP) is a heterogeneous syndrome in terms of clinical manifestations, heritability and etiology of the disease. Genetic…”
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