Search Results - "Grolla, Ambra A."

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy by Galli, Ubaldina, Colombo, Giorgia, Travelli, Cristina, Tron, Gian Cesare, Genazzani, Armando A., Grolla, Ambra A.

“…Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g.,…”
Get full text

Pericytes: jack-of-all-trades in cancer-related inflammation by Moro, Marianna, Balestrero, Federica Carolina, Grolla, Ambra A

“…Pericytes, recognized as mural cells, have long been described as components involved in blood vessel formation, playing a mere supporting role for endothelial…”
Get full text

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB by Lim, Dmitry, Iyer, Anand, Ronco, Virginia, Grolla, Ambra A., Canonico, Pier Luigi, Aronica, Eleonora, Genazzani, Armando A.

“…The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is an initiator of a cascade of events eventually leading to…”
Get full text

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids by Mola, Silvia, Pinton, Giulia, Erreni, Marco, Corazzari, Marco, De Andrea, Marco, Grolla, Ambra A, Martini, Veronica, Moro, Laura, Porta, Chiara

“…Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a long latency period and dismal prognosis. Recently, tazemetostat (EPZ-6438), an…”
Get full text

Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma by Grolla, Ambra A., Torretta, Simone, Gnemmi, Ilaria, Amoruso, Angela, Orsomando, Giuseppe, Gatti, Marco, Caldarelli, Antonio, Lim, Dmitry, Penengo, Lorenza, Brunelleschi, Sandra, Genazzani, Armando A., Travelli, Cristina

“…Summary High plasma levels of nicotinamide phosphoribosyltransferase (NAMPT), traditionally considered an intracellular enzyme with a key role in NAD…”
Get full text

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction by Tapella, Laura, Dematteis, Giulia, Moro, Marianna, Pistolato, Beatrice, Tonelli, Elisa, Vanella, Virginia Vita, Giustina, Daniele, La Forgia, Aleida, Restelli, Elena, Barberis, Elettra, Cali, Tito, Brini, Marisa, Villani, Salvatore, Del Grosso, Erika, Grilli, Mariagrazia, Manfredi, Marcello, Corazzari, Marco, Grolla, Ambra A., Genazzani, Armando A., Lim, Dmitry

“…Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR) have been reported in astrocytes. However, the relationships between…”
Get full text

OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression by Masi, Mirco, Garattini, Enrico, Bolis, Marco, Di Marino, Daniele, Maraccani, Luisa, Morelli, Elena, Grolla, Ambra A., Fagiani, Francesca, Corsini, Emanuela, Travelli, Cristina, Govoni, Stefano, Racchi, Marco, Buoso, Erica

“…Recent data indicate that receptor for activated C kinase 1 (RACK1) is a putative prognostic marker and drug target in breast cancer (BC). High RACK1…”
Get full text

Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases by Amici, Adolfo, Grolla, Ambra A, Del Grosso, Erika, Bellini, Roberta, Bianchi, Michele, Travelli, Cristina, Garavaglia, Silvia, Sorci, Leonardo, Raffaelli, Nadia, Ruggieri, Silverio, Genazzani, Armando A, Orsomando, Giuseppe

“…Adenosine 5'-tetraphosphate (Ap4) is a ubiquitous metabolite involved in cell signaling in mammals. Its full physiological significance remains unknown. Here…”
Get more information

The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5) by Torretta, Simone, Colombo, Giorgia, Travelli, Cristina, Boumya, Sara, Lim, Dmitry, Genazzani, Armando A, Grolla, Ambra A

“…(1) Background: Extracellular nicotinamide phosphoribosyltrasferase (eNAMPT) is released by various cell types with pro-tumoral and pro-inflammatory…”
Get full text

Triazole-curcuminoids: A new class of derivatives for ‘tuning’ curcumin bioactivities? by Caprioglio, Diego, Torretta, Simone, Ferrari, Maila, Travelli, Cristina, Grolla, Ambra A., Condorelli, Fabrizio, Genazzani, Armando A., Minassi, Alberto

“…[Display omitted] Curcumin is a unique blend of pharmacophores responsible for the pleiotropy of this natural pigment. In the present study we have replaced…”
Get full text

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer by Travelli, Cristina, Colombo, Giorgia, Aliotta, Martina, Fagiani, Francesca, Fava, Natalia, De Sanctis, Rita, Grolla, Ambra A, Garcia, Joe G N, Clemente, Nausicaa, Portararo, Paola, Costanza, Massimo, Condorelli, Fabrizio, Colombo, Mario Paolo, Sangaletti, Sabina, Genazzani, Armando A

“…BackgroundNicotinamide phosphoribosyltransferase (NAMPT) is a key intracellular enzyme that participates in nicotinamide adenine dinucleotide (NAD) homeostasis…”
Get full text

Editorial: Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response by Ravegnini, Gloria, Del Re, Marzia, Grolla, Ambra A., van Schaik, Ron H. N., Angelini, Sabrina

Get full text

Characterization of NAD Uptake in Mammalian Cells by Billington, Richard A., Travelli, Cristina, Ercolano, Emanuela, Galli, Ubaldina, Roman, Cintia Blasi, Grolla, Ambra A., Canonico, Pier Luigi, Condorelli, Fabrizio, Genazzani, Armando A.

“…Recent evidence has shown that NAD(P) plays a variety of roles in cell-signaling processes. Surprisingly, the presence of NAD(P) utilizing ectoenzymes suggests…”
Get full text

Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine by Grolla, Ambra A, Travelli, Cristina, Genazzani, Armando A, Sethi, Jaswinder K

“…In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre‐B cell…”
Get full text

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway by Fakhfouri, Gohar, Ahmadiani, Abolhasan, Rahimian, Reza, Grolla, Ambra A., Moradi, Fatemeh, Haeri, Ali

“…Cannabinoids have been shown to exert neuroprotective effects in a plethora of neurodegenerative conditions. Over the past decade, some studies demonstrate…”
Get full text

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells by Travelli, Cristina, Consonni, Francesca Maria, Sangaletti, Sabina, Storto, Mariangela, Morlacchi, Sara, Grolla, Ambra A, Galli, Ubaldina, Tron, Gian Cesare, Portararo, Paola, Rimassa, Lorenza, Pressiani, Tiziana, Mazzone, Massimiliano, Trovato, Rosalinda, Ugel, Stefano, Bronte, Vincenzo, Tripodo, Claudio, Colombo, Mario P, Genazzani, Armando A, Sica, Antonio

“…Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates…”
Get full text

Functionalization of β-cyclodextrin with a urea-based PSMA ligand and preliminary studies on targeting prostate cancer cells by Imperio, Daniela, Grolla, Ambra A., Moro, Marianna, Bortolotto, Valeria, Del Grosso, Erika, Genazzani, Armando A., Panza, Luigi

“…[Display omitted] Targeted delivery of drugs into specific cancer cells is an effective way to enhance the efficacy and minimize the side effects of therapy…”
Get full text

Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS by Ronco, Virginia, Grolla, Ambra A, Glasnov, Toma N, Canonico, Pier Luigi, Verkhratsky, Alexei, Genazzani, Armando A, Lim, Dmitry

“…Abstract In Alzheimer's disease (AD), astrocytes undergo complex morphological and functional changes that include early atrophy, reactive activation and Ca2+…”
Get full text

Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction by Foroutan, Arash, Corazzari, Marco, Grolla, Ambra A, Colombo, Giorgia, Travelli, Cristina, Genazzani, Armando A, Theeramunkong, Sewan, Galli, Ubaldina, Tron, Gian Cesare

“…Despite novel biological targets emerging at an impressive rate for anticancer therapy, antitubulin drugs remain the backbone of numerous oncological protocols…”
Get full text

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity by Travelli, Cristina, Aprile, Silvio, Rahimian, Reza, Grolla, Ambra A, Rogati, Federica, Bertolotti, Mattia, Malagnino, Floriana, di Paola, Rosanna, Impellizzeri, Daniela, Fusco, Roberta, Mercalli, Valentina, Massarotti, Alberto, Stortini, Giorgio, Terrazzino, Salvatore, Del Grosso, Erika, Fakhfouri, Gohar, Troiani, Maria Pia, Alisi, Maria Alessandra, Grosa, Giorgio, Sorba, Giovanni, Canonico, Pier Luigi, Orsomando, Giuseppe, Cuzzocrea, Salvatore, Genazzani, Armando A, Galli, Ubaldina, Tron, Gian Cesare

“…Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside the cells. It…”
Get full text