Search Results - "Groll, Nicola"

Application of HC-AFW1 Hepatocarcinoma Cells for Mechanistic Studies: Regulation of Cytochrome P450 2B6 Expression by Dimethyl Sulfoxide and Early Growth Response 1 by Petzuch, Barbara, Groll, Nicola, Schwarz, Michael, Braeuning, Albert

“…Various exogenous compounds, for example, the drugs bupropione and propofol, but also various cytostatics, are metabolized in the liver by the enzyme…”
Get full text

A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib by Sinnberg, Tobias, Makino, Elena, Krueger, Marcel A., Velic, Ana, Macek, Boris, Rothbauer, Ulrich, Groll, Nicola, Pötz, Oliver, Czemmel, Stefan, Niessner, Heike, Meier, Friedegund, Ikenberg, Kristian, Garbe, Claus, Schittek, Birgit

“…Acquired resistance to second generation BRAF inhibitors (BRAFis), like vemurafenib is limiting the benefits of long term targeted therapy for patients with…”
Get full text

Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells by Groll, Nicola, Kollotzek, Ferdinand, Goepfert, Jens, Joos, Thomas O, Schwarz, Michael, Braeuning, Albert

“…The antiepileptic drug phenobarbital (PB) exerts hepatic effects related to cell proliferation and tumorigenesis which are closely linked to the Wnt/β-catenin…”
Get more information

Towards multiplexed protein–protein interaction analysis using protein tag-specific nanobodies by Groll, Nicola, Emele, Felix, Poetz, Oliver, Rothbauer, Ulrich

“…Dynamic protein–protein interactions (PPIs) are an integral part of cellular processes. The discovery of modulators that disrupt or stabilize such interactions…”
Get full text

Coordinate regulation of Cyp2e1 by β-catenin- and hepatocyte nuclear factor 1α-dependent signaling by Groll, Nicola, Petrikat, Tamara, Vetter, Silvia, Colnot, Sabine, Weiss, Frederik, Poetz, Oliver, Joos, Thomas O, Rothbauer, Ulrich, Schwarz, Michael, Braeuning, Albert

“…Abstract Depending on their position within the liver lobule, hepatocytes fulfill different metabolic functions. Cytochrome P450 (CYP) 2E1 is a…”
Get full text

Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro by Groll, Nicola, Petrikat, Tamara, Vetter, Silvia, Wenz, Christine, Dengjel, Joern, Gretzmeier, Christine, Weiss, Frederik, Poetz, Oliver, Joos, Thomas O, Schwarz, Michael, Braeuning, Albert

“…Abstract The antiepileptic drug phenobarbital (PB) exerts hepatic effect based on indirect activation of the constitutive androstane receptor (CAR) via…”
Get full text

A bead-based multiplex sandwich immunoassay to assess the abundance and posttranslational modification state of β-catenin by Groll, Nicola, Sommersdorf, Cornelia, Joos, Thomas O, Poetz, Oliver

“…A system-wide analysis of cell signaling involves detecting and quantifying a range of proteins and their posttranslational modification states in the same…”
Get more information