Molecular and Clinical Profiles of Human Pegivirus Type 1 Infection in Individuals Living with HIV-1 in the Extreme South of Brazil

Human pegivirus type 1 (HPgV-1) infection has been associated with a beneficial effect on the prognosis of human immunodeficiency virus type 1 (HIV-1)-coinfected individuals. However, the mechanisms involved in this protection are not yet fully elucidated. To date, circulating HPgV-1 genotypes in HI...

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Published in:	BioMed research international Vol. 2019; no. 2019; pp. 1 - 11
Main Authors:	Groll, Andrea V., Silveira, Jussara M., Basso, Rossana P., Soares, Marcelo A., Martínez, Ana M. B., Chies, José Artur, Luquez, Karen Y. Sánchez, Gonçalves, Carla V., Nader, Maiba M., Germano, Fabiana N., Silva, Cláudio M., Finger-Jardim, Fabiana, Mota, Luísa D. Da, Hora, Vanusa P. Da
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01-01-2019 Hindawi John Wiley & Sons, Inc Hindawi Limited
Subjects:	Acquired immune deficiency syndrome Adult AIDS Antiretroviral agents Antiretroviral drugs B cells Brazil CD4 antigen CD4 Lymphocyte Count - methods Coinfection - virology Comorbidity Evolution Female GB virus C - genetics Genotype Genotype & phenotype Genotypes Genotyping Health aspects Hepatitis Highly active antiretroviral therapy HIV HIV (Viruses) HIV Infections - virology HIV patients HIV-1 - genetics Human immunodeficiency virus Humans Infection Infections Infectious diseases Laboratories Lymphocytes Lymphocytes T Male Patients Pilot Projects Prognosis Retrospective Studies Ribonucleic acid RNA RNA, Viral - genetics T cells Transcription Viral infections Viral Load - genetics Virology Viruses Brazil China
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Summary:	Human pegivirus type 1 (HPgV-1) infection has been associated with a beneficial effect on the prognosis of human immunodeficiency virus type 1 (HIV-1)-coinfected individuals. However, the mechanisms involved in this protection are not yet fully elucidated. To date, circulating HPgV-1 genotypes in HIV-1-infected individuals have not yet been identified in the extreme south of Brazil. The present study aimed to determine the genotypic circulation of HPgV-1 and the influence of HPgV-1 status and persistence time on the evolution of HIV-1 infection. A retrospective cohort of 110 coinfected individuals was analyzed. Samples were subjected to viral RNA extraction, cDNA synthesis, nested PCR, and genotyping. Genotypes 1 (2.8%), 2 (47.9% of subtype 2a and 42.3% of subtype 2b), and 3 (7%) were identified. In antiretroviral treatment-naïve subjects HPgV-1 subtype 2b was associated with lower HIV-1 viral load (VL) rates (p = 0.04) and higher CD4+ T-cell counts (p = 0.03) than was subtype 2a, and the positivity for HPgV-1 was associated with higher CD4+ T-cell counts (p = 0.02). However, there was no significant difference in HIV-1 VL between HPgV-1-positive and HPgV-1-negative subjects (p = 0.08). There was no significant association between the different groups in HPgV-1 persistence and median HIV-1 VL (p = 0.66) or CD4+ T-cell counts (p = 0.15). HPgV-1 subtype 2b is associated with better prognosis of HIV-1 infection. Although HPgV-1 infection is persistent, our data suggest that the time of infection does not influence HIV-1 VL or CD4+ T-cell counts in coinfected subjects.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Lucia Lopalco
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2019/8048670