Search Results - "Grokhovsky, S L"

Use of β Radiation to Localize the Binding Sites of Mercury Ions and Platinum-Containing Ligand in DNA by Grokhovsky, S. L.

“…Composite sequence-specific ligands with DNA-damaging groups may dramatically increase the efficacy of radiotherapy. The most promising damage sensitizers are…”
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Ultrasonic Footprinting by Grokhovsky, S. L.

“…Ligand binding influences the dynamics of the DNA helix in both the binding site and adjacent regions. This, in particular, is reflected in the changing…”
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Targeting Holliday junctions by origin DNA-binding protein of herpes simplex virus type 1 by Moiseeva, E.D., Bazhulina, N.P., Gursky, Y.G., Grokhovsky, S.L., Surovaya, A.N., Gursky, G.V.

“…In the present paper, the interactions of the origin binding protein (OBP) of herpes simplex virus type 1 (HSV1) with synthetic four-way Holliday junctions…”
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Sequence-Specific Minor Groove Binding Ligands as Potential Regulators of Gene Expression in Xenopus Laevis Oocytes by Belikov, S. V., Grokhovsky, S. L., Isaguliants, M. G., Surovaya, A. N., Gursky, G. V.

“…The mouse mammary tumor virus (MMTV) promoter is induced by glucocorticoid hormone. A robust hormone- and receptor-dependent gene activation could be…”
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DNA sequence recognition by bis-linked netropsin and distamycin derivatives by Grokhovsky, S.L, Surovaya, A.N, Burckhardt, G, Pismensky, V.F, Chernov, B.K, Zimmer, Ch, Gursky, G.V

“…We studied the interaction of cis-diammine Pt(II)-bridged bis-netropsin, cis-diammine Pt(II)-bridged bis-distamycin and oligomethylene-bridged bis-netropsin…”
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Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs by Bazhulina, N.P., Surovaya, A.N., Gursky, Y.G., Andronova, V.L., Moiseeva, E.D., Nikitin, А.M., Golovkin, M.V., Galegov, G.А., Grokhovsky, S.L., Gursky, G.V.

“…The herpes simplex virus type 1 origin-binding protein, OBP, is a DNA helicase encoded by the UL9 gene. The protein binds in a sequence-specific manner to the…”
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Specificity of DNA cleavage by ultrasound by Grokhovsky, S L

“…Cleavage of double-stranded DNA fragments with known nucleotide sequences upon sonication at 22 and 44 kHz was studied by PAGE. The cleavage rate was shown to…”
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Ultrasonic Cleavage of Nicked DNA by Il'icheva, I. A., Nechipurenko, D. Yu, Grokhovsky, S. L.

“…Structural properties of nicked dsDNA have been an object of numerous studies due to their special role in reparation processes. Here we report experimental…”
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Effect of dimeric netropsin analogue 15Lys-bis-Nt and acyclovir on the reproduction of herpes simplex virus type 1. The search for variants of herpes virus with drug resistance to 15Lys-bis-Nt and acyclovir by Andronova, V. L., Grokhovsky, S. L., Surovaya, A. N., Gursky, G. V., Galegov, G. A.

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DNA Sequence-Specific Ligands: XII. Synthesis and Cytological Studies of Dimeric Hoechst 33258 Molecules by Gromyko, A. V., Popov, K. V., Mosoleva, A. P., Streltsov, S. A., Grokhovsky, S. L., Oleinikov, V. A., Zhuze, A. L.

“…We synthesized dimeric Hoechst dye molecules composed of two moieties of Hoechst 33258 fluorescent dye with the phenolic hydroxy groups tethered via…”
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Binding of Bis-linked Netropsin Derivatives in the Parallel-Stranded Hairpin Form to DNA by Surovaya, A. N., Burckhardt, G., Grokhovsky, S. L., Birch-Hirschfeld, E., Nikitin, A. M., Fritzsche, H., Zimmer, Ch, Gursky, G. V.

“…Cis-diammine Pt(II)- bridged bis-netropsin and oligomethylene-bridged bis-netropsin in which two monomers are linked in a tail-to-tail manner bind to the DNA…”
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Sequence-specific cleavage of double-stranded DNA caused by X-ray ionization of the platinum atom in the Pt-Bis-netropsin : DNA complex by GROKHOVSKY, S. L, ZUBAREV, V. E

“…An analog of the antibiotic netropsin containing two netropsin-like fragments linked covalently via a platinum atom has been synthesized. DNase I and hydroxyl…”
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Interaction of Topotecan, DNA Topoisomerase I Inhibitor, with Double-Stranded Polydeoxyribonucleotides. 5. Topotecan is Capable of Producing Single- and Double-Strand Breaks in Circular Supercoiled DNA in the Absence of the Enzyme by Grokhovsky, S. L., Strel'tsov, S. A., Zhuze, A. L.

“…A study was made of the temperature, concentration, and time dependences for the emergence of breaks in the sugar-phosphate backbone of a circular supercoiled…”
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Use of β Radiation to Localize the Binding Sites of Mercury Ions and Platinum-Containing Ligand in DNA by Grokhovsky, S L

“…Composite sequence-specific ligands with DNA-damaging groups may dramatically increase the efficacy of radiotherapy. The most promising damage sensitizers are…”
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Effect of DNA Local Conformation on the Affinity and Binding Specificity of bis-Netropsins to DNA by Surovaya, A N, Grokhovsky, S L, Burckhardt, G, Fritzsche, H, Zimmer, Ch, Gursky, G V

“…The interaction of short nucleotide duplexes with bis-netropsins, in which netropsin fragments are linked tail-to-tail via cis-diammineplatinum group ([arrow…”
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Interaction of Topotecan, DNA Topoisomerase I Inhibitor, with Double-stranded Polydeoxyribonucleotides. 4. Topotecan Binds Preferably to the GC Base Pairs of DNA by Strel'tsov, S A, Mikheikin, A L, Grokhovsky, S L, Oleinikov, V A, Kudelina, I A, Zhuze, A L

“…Interaction of topotecan (TPT) with synthetic double-stranded polydeoxyribonucleotides has been studied in solutions of low ionic strength at pH 6.8 by linear…”
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Interaction of Topotecan, DNA Topoisomerase I Inhibitor, with Double-stranded Polydeoxyribonucleotides. 3. Binding at the Minor Groove by Strel'tsov, S A, Mikheikin, A L, Grokhovsky, S L, Oleinikov, V A, Zhuze, A L

“…Interaction of topotecan (TPT) with calf thymus DNA, coliphage T4 DNA, and poly(dGdC) · poly(dG-dC) was studied by optical (linear flow dichroism, UV-vis…”
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Design of sequence-specific DNA binding ligands that use a two-stranded peptide motif for DNA sequence recognition by Nikolaev, V A, Grokhovsky, S L, Surovaya, A N, Leinsoo, T A, Sidorova NYu, Zasedatelev, A S, Zhuze, A L, Strahan, G A, Shafer, R H, Gursky, G V

“…The design and DNA binding activity of beta-structure-forming peptides and netropsin-peptide conjugates are reported. It is found that a pair of…”
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Antiviral and cytotoxic activity of netropsin derivatives in vero cells infected with vaccinia virus and herpes simplex virus type I by Andronova, V. L., Grokhovsky, S. L., Surovaya, A. N., Arkhipova, V. S., Gursky, G. V., Galegov, G. A.

“…A study examined the antiviral activity of a series of new netropsin derivatives in Vero E6 cells infected with vaccinia virus and herpes simplex virus type I…”
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The antiviral activity of the combinations of netropsin derivatives with modified nucleosides and phosphonoacetic acid as estimated in the model of herpesvirus type 1 in a vero cell culture by Andronova, V L, Grokhovsky, S L, Surovaya, A N, Gursky, G V, Galegov, G A

“…(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]…”
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