Search Results - "Grojean, Stéphanie"
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Bilirubin Induces Apoptosis via Activation of NMDA Receptors in Developing Rat Brain Neurons
Published in Experimental neurology (01-12-2000)“…Increased amounts of bilirubin, the end product of heme degradation, are known to be detrimental to the central nervous system, especially in preterm newborns…”
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The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart ‘OMics’ in AGEing (HOMAGE) randomized clinical trial
Published in European heart journal (11-02-2021)“…Abstract Aims To investigate the effects of spironolactone on fibrosis and cardiac function in people at increased risk of developing heart failure. Methods…”
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3
Proteomic and Mechanistic Analysis of Spironolactone in Patients at Risk for HF
Published in JACC. Heart failure (01-04-2021)“…This study sought to further understand the mechanisms underlying effect of spironolactone and assessed its impact on multiple plasma protein biomarkers and…”
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4
Neonatal Hypoxia Triggers Transient Apoptosis Followed by Neurogenesis in the Rat CA1 Hippocampus
Published in Pediatric research (01-04-2004)Get full text
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The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart ‘OMics’ in AGEing (HOMAGE) randomized clinical trial
Published in European heart journal (07-02-2021)“…Abstract Aims To investigate the effects of spironolactone on fibrosis and cardiac function in people at increased risk of developing heart failure. Methods…”
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6
Histopathological alterations and functional brain deficits after transient hypoxia in the newborn rat pup: a long term follow-up
Published in Neurobiology of disease (01-11-2003)“…To assess temporal brain deficits consecutive to severe birth hypoxia, newborn rats were exposed for 20 min to 100% N 2. This treatment induced a long-term…”
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Bilirubin exerts additional toxic effects in hypoxic cultured neurons from the developing rat brain by the recruitment of glutamate neurotoxicity
Published in Pediatric research (01-04-2001)“…Both hypoxia and bilirubin are common risk factors in newborns, which may act synergistically to produce anatomical and functional disturbances of the CNS…”
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Neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat CA1 hippocampus
Published in Pediatric research (01-04-2004)“…Continuous generation of new neurons has been demonstrated in the adult mammalian brain, and this process was shown to be stimulated by various pathologic…”
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EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015
Published in The EPMA journal (09-05-2016)“…Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular…”
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Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial
Published in Heart (British Cardiac Society) (09-05-2024)“…Heart failure (HF) is characterised by collagen deposition. Urinary proteomic profiling (UPP) followed by peptide sequencing identifies parental proteins, for…”
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Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial
Published in Hypertension research (06-09-2024)“…None of the spironolactone trials in heart failure (HF) assessed the blood pressure (BP) responses to exercise, while conflicting results were reported for…”
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Differential neuronal fates in the CA1 hippocampus after hypoxia in newborn and 7-day-old rats: Effects of pre-treatment with MK-801
Published in Hippocampus (2003)“…The brain displays an age‐dependent sensitivity to ischemic insults. However, the consequences of oxygen deprivation per se in the developing brain remain…”
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13
Combined effects of bilirubin and hypoxia on cultured neurons from the developing rat forebrain
Published in Seminars in perinatology (01-12-2002)“…Hyperbilirubinemia and hypoxia are common causes of brain injury in the newborn. To determine the effects of free bilirubin associated with transient hypoxia…”
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