Search Results - "Grohn, Olli"

Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury by van Vliet, Erwin A., Ndode-Ekane, Xavier Ekolle, Lehto, Lauri J., Gorter, Jan A., Andrade, Pedro, Aronica, Eleonora, Gröhn, Olli, Pitkänen, Asla

“…Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We…”
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Advances in the development of biomarkers for epilepsy by Pitkänen, Asla, Prof, Löscher, Wolfgang, Prof, Vezzani, Annamaria, Prof, Becker, Albert J, Prof, Simonato, Michele, Prof, Lukasiuk, Katarzyna, Prof, Gröhn, Olli, Prof, Bankstahl, Jens P, PhD, Friedman, Alon, Prof, Aronica, Eleonora, Prof, Gorter, Jan A, Prof, Ravizza, Teresa, PhD, Sisodiya, Sanjay M, Prof, Kokaia, Merab, Prof, Beck, Heinz, Prof

“…Summary Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of…”
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Axon fiber orientation as the source of T1 relaxation anisotropy in white matter: A study on corpus callosum in vivo and ex vivo by Kauppinen, Risto A., Thothard, Jeromy, Leskinen, Henri P. P., Pisharady, Pramod K., Manninen, Eppu, Kettunen, Mikko, Lenglet, Christophe, Gröhn, Olli H. J., Garwood, Michael, Nissi, Mikko J.

“…Purpose Recent studies indicate that T1 in white matter (WM) is influenced by fiber orientation in B0. The purpose of the study was to investigate the…”
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Automated joint skull-stripping and segmentation with Multi-Task U-Net in large mouse brain MRI databases by De Feo, Riccardo, Shatillo, Artem, Sierra, Alejandra, Valverde, Juan Miguel, Gröhn, Olli, Giove, Federico, Tohka, Jussi

“…•We present convolutional neural network (MU-Net) for segmentation of mouse brain MRI.•MU-Net yielded an excellent performance when tested on 1782 mouse MRI…”
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Relaxation anisotropy of quantitative MRI parameters in biological tissues by Hänninen, Nina Elina, Liimatainen, Timo, Hanni, Matti, Gröhn, Olli, Nieminen, Miika Tapio, Nissi, Mikko Johannes

“…Quantitative MR relaxation parameters vary in the sensitivity to the orientation of the tissue in the magnetic field. In this study, the orientation dependence…”
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Quantification of anisotropy and orientation in 3D electron microscopy and diffusion tensor imaging in injured rat brain by Salo, Raimo A., Belevich, Ilya, Manninen, Eppu, Jokitalo, Eija, Gröhn, Olli, Sierra, Alejandra

“…Diffusion tensor imaging (DTI) reveals microstructural features of grey and white matter non-invasively. The contrast produced by DTI, however, is not fully…”
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From traumatic brain injury to posttraumatic epilepsy: What animal models tell us about the process and treatment options by Pitkänen, Asla, Immonen, Riikka J., Gröhn, Olli H.J., Kharatishvili, Irina

“…Summary A large number of animal models of traumatic brain injury (TBI) are already available for studies on mechanisms and experimental treatments of TBI…”
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Post-injury ventricular enlargement associates with iron in choroid plexus but not with seizure susceptibility nor lesion atrophy—6-month MRI follow-up after experimental traumatic brain injury by Yasmin, Amna, Pitkänen, Asla, Andrade, Pedro, Paananen, Tomi, Gröhn, Olli, Immonen, Riikka

“…Ventricular enlargement is one long-term consequence of a traumatic brain injury, and a risk factor for memory disorders and epilepsy. One underlying…”
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Isoflurane affects brain functional connectivity in rats 1 month after exposure by Stenroos, Petteri, Pirttimäki, Tiina, Paasonen, Jaakko, Paasonen, Ekaterina, Salo, Raimo A, Koivisto, Hennariikka, Natunen, Teemu, Mäkinen, Petra, Kuulasmaa, Teemu, Hiltunen, Mikko, Tanila, Heikki, Gröhn, Olli

“…Isoflurane, the most commonly used preclinical anesthetic, induces brain plasticity and long-term cellular and molecular changes leading to behavioral and/or…”
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Early maternal alcohol consumption alters hippocampal DNA methylation, gene expression and volume in a mouse model by Marjonen, Heidi, Sierra, Alejandra, Nyman, Anna, Rogojin, Vladimir, Gröhn, Olli, Linden, Anni-Maija, Hautaniemi, Sampsa, Kaminen-Ahola, Nina

“…The adverse effects of alcohol consumption during pregnancy are known, but the molecular events that lead to the phenotypic characteristics are unclear. To…”
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Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents by Sirmpilatze, Nikoloz, Mylius, Judith, Ortiz-Rios, Michael, Baudewig, Jürgen, Paasonen, Jaakko, Golkowski, Daniel, Ranft, Andreas, Ilg, Rüdiger, Gröhn, Olli, Boretius, Susann

“…During deep anesthesia, the electroencephalographic (EEG) signal of the brain alternates between bursts of activity and periods of relative silence…”
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Quantitative MRI predicts long-term structural and functional outcome after experimental traumatic brain injury by Immonen, Riikka J., Kharatishvili, Irina, Gröhn, Heidi, Pitkänen, Asla, Gröhn, Olli H.J.

“…In traumatic brain injury (TBI) the initial impact causes both immediate damage and also launches a cascade of slowly progressive secondary damage. The chronic…”
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Awake Rat Brain Functional Magnetic Resonance Imaging Using Standard Radio Frequency Coils and a 3D Printed Restraint Kit by Stenroos, Petteri, Paasonen, Jaakko, Salo, Raimo A, Jokivarsi, Kimmo, Shatillo, Artem, Tanila, Heikki, Gröhn, Olli

“…Functional magnetic resonance imaging (fMRI) is a powerful noninvasive tool for studying spontaneous resting state functional connectivity (RSFC) in laboratory…”
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Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat by Paasonen, Jaakko, Laakso, Hanne, Pirttimäki, Tiina, Stenroos, Petteri, Salo, Raimo A., Zhurakovskaya, Ekaterina, Lehto, Lauri J., Tanila, Heikki, Garwood, Michael, Michaeli, Shalom, Idiyatullin, Djaudat, Mangia, Silvia, Gröhn, Olli

“…Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially…”
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Spontaneous BOLD waves – A novel hemodynamic activity in Sprague-Dawley rat brain detected by functional magnetic resonance imaging by Shatillo, Artem, Lipponen, Arto, Salo, Raimo A, Tanila, Heikki, Verkhratsky, Alexei, Giniatullin, Rashid, Gröhn, Olli H

“…We report spontaneous hemodynamic activity termed “Spontaneous BOLD Waves” (SBWs) detected by BOLD fMRI in Sprague-Dawley rats under medetomidine anesthesia…”
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Brain fMRI during orientation selective epidural spinal cord stimulation by Canna, Antonietta, Lehto, Lauri J., Wu, Lin, Sang, Sheng, Laakso, Hanne, Ma, Jun, Filip, Pavel, Zhang, Yuan, Gröhn, Olli, Esposito, Fabrizio, Chen, Clark C., Lavrov, Igor, Michaeli, Shalom, Mangia, Silvia

“…Epidural spinal cord stimulation (ESCS) is widely used for chronic pain treatment, and is also a promising tool for restoring motor function after spinal cord…”
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Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI by Paasonen, Jaakko, Stenroos, Petteri, Laakso, Hanne, Pirttimäki, Tiina, Paasonen, Ekaterina, Salo, Raimo A., Tanila, Heikki, Idiyatullin, Djaudat, Garwood, Michael, Michaeli, Shalom, Mangia, Silvia, Gröhn, Olli

“…•MB-SWIFT fMRI allows imaging of head-fixed spontaneously behaving rats.•Anatomically relevant functional parcellation was obtained.•Brain activity in relevant…”
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Distinct MRI pattern in lesional and perilesional area after traumatic brain injury in rat — 11 months follow-up by Immonen, Riikka J., Kharatishvili, Irina, Niskanen, Juha-Pekka, Gröhn, Heidi, Pitkänen, Asla, Gröhn, Olli H.J.

“…To understand the dynamics of progressive brain damage after lateral fluid-percussion induced traumatic brain injury (TBI) in rat, which is the most widely…”
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A spatiotemporal theory for MRI T2 relaxation time and apparent diffusion coefficient in the brain during acute ischaemia: Application and validation in a rat acute stroke model by Knight, Michael J, McGarry, Bryony L, Rogers, Harriet J, Jokivarsi, Kimmo T, Gröhn, Olli HJ, Kauppinen, Risto A

“…The objective of this study is to present a mathematical model which can describe the spatiotemporal progression of cerebral ischaemia and predict magnetic…”
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Plasma Neurofilament Light Chain (NF-L) Is a Prognostic Biomarker for Cortical Damage Evolution but Not for Cognitive Impairment or Epileptogenesis Following Experimental TBI by Heiskanen, Mette, Jääskeläinen, Olli, Manninen, Eppu, Das Gupta, Shalini, Andrade, Pedro, Ciszek, Robert, Gröhn, Olli, Herukka, Sanna-Kaisa, Puhakka, Noora, Pitkänen, Asla

“…Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for traumatic brain injury (TBI) and as a prognostic biomarker for…”
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