Search Results - "Grogan, JL"

Synergistic blockade of TIGIT and PD-L1 increases type-1 inflammation and improves parasite control during murine blood-stage Plasmodium yoelii non-lethal infection by Dookie, Rebecca S, Villegas-Mendez, Ana, Cheeseman, Antonn, Jones, Adam P, Barroso, Ruben, Barrett, Jordan R, Draper, Simon J, Janse, Chris J, Grogan, Jane L, MacDonald, Andrew S, Couper, Kevin N

“…Pro-inflammatory immune responses are rapidly suppressed during blood-stage malaria but the molecular mechanisms driving this regulation are still incompletely…”
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Early Transcription and Silencing of Cytokine Genes Underlie Polarization of T Helper Cell Subsets by Grogan, Jane L., Mohrs, Markus, Harmon, Brian, Lacy, Dee A., Sedat, John W., Locksley, Richard M.

“…Naive CD4 + T cells activated through TCR/CD28 under Th1 or Th2 conditions expressed canonical cytokine patterns irrespective of cell division. Only cells that…”
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T helper cell differentiation: on again, off again by Grogan, Jane L, Locksley, Richard M

“…Recent studies raise the possibility that T helper (Th) polarization may be attributable to generalized activation and regulated silencing rather than…”
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T1/ST2 is Preferentially Expressed on Murine Th2 Cells, Independent of Interleukin 4, Interleukin 5, and Interleukin 10, and Important for Th2 Effector Function by Lohning, Max, Stroehmann, Arne, Coyle, Anthony J., Grogan, Jane L., Lin, Steven, Gutierrez-Ramos, Jose-Carlos, Levinson, Douglas, Radbruch, Andreas, Kamradt, Thomas

“…T helper (Th) cells can be categorized according to their cytokine expression. The differential induction of Th cells expressing Th1 and/or Th2 cytokines is…”
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CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment by Bour-Jordan, Hélène, Grogan, Jane L, Tang, Qizhi, Auger, Julie A, Locksley, Richard M, Bluestone, Jeffrey A

“…The relative importance of the cytokine milieu versus cytolytic T lymphocyte-associated antigen 4 (CTLA-4) and T cell receptor signal strength on T cell…”
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Modulation of Blood Fluke Development in the Liver by Hepatic CD4+Lymphocytes by Davies, Stephen J., Grogan, Jane L., Blank, Rebecca B., Lim, K. C., Locksley, Richard M., McKerrow, James H.

“…We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immuno-deficient…”
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Human IgE response to the Schistosoma haematobium 22.6 kDa antigen by Fitzsimmons, C M, Stewart, T J, Hoffmann, Karl F, Grogan, Jane L, Yazdanbakhsh, Maria, Dunne, David W

“…In Schistosoma mansoni and S. japonicum infection, the 22.6 kDa tegumental antigens Sm22.6 and Sj22.6 are principal targets for the human IgE response, and…”
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Basal Chromatin Modification at the IL-4 Gene in Helper T Cells by Grogan, Jane L, Wang, Zhi-En, Stanley, Sarah, Harmon, Brian, Loots, Gaby G, Rubin, Edward M, Locksley, Richard M

“…Chromatin immunoprecipitations in naive CD4, but not CD8, T cells, demonstrated association of the IL-4 promoter with acetylated histone. Histone modifications…”
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Cross-Reactivity of Myelin Basic Protein-Specific T Cells with Multiple Microbial Peptides: Experimental Autoimmune Encephalomyelitis Induction in TCR Transgenic Mice by Grogan, Jane L, Kramer, Achim, Nogai, Axel, Dong, Liying, Ohde, Manuela, Schneider-Mergener, Jens, Kamradt, Thomas

“…Activation of autoreactive T cells is a crucial event in the pathogenesis of autoimmune diseases. Cross-reactivity between microbial and self Ags (molecular…”
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Antigen-Specific Proliferation and Interferon-γ and Interleukin-5 Production Are Down-Regulated during Schistosoma haematobium Infection by Grogan, Jane L., Kremsner, Peter G., Deelder, André M., Yazdanbakhsh, Maria

“…Antigen-specific cellular immune responses were examined in persons previously infected with Schistosoma haematobium and who were, 2 years after chemotherapy,…”
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Th2 cells: orchestrating barrier immunity by Stetson, Daniel B, Voehringer, David, Grogan, Jane L, Xu, Min, Reinhardt, R Lee, Scheu, Stefanie, Kelly, Ben L, Locksley, Richard M

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CD30 expression does not discriminate between human Th1- and Th2-type T cells by Hamann, D, Hilkens, CM, Grogan, JL, Lens, SM, Kapsenberg, ML, Yazdanbakhsh, M, van Lier, RA

“…CD30 is a member of the TNF receptor superfamily that is commonly used as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease. More recently, it…”
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T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo by Lohning, Max, Grogan, Jane L, Coyle, Anthony J, Yazdanbakhsh, Maria, Meisel, Christian, Gutierrez-Ramos, Jose-Carlos, Radbruch, Andreas, Kamradt, Thomas

“…Th cells are categorized into subsets based on the cytokine production of in vitro-differentiated Th populations. For in vivo-differentiated Th subsets, little…”
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Elevated proliferation and interleukin-4 release from CD4+ cells after chemotherapy in human Schistosoma haematobium infection by Grogan, J L, Kremsner, P G, Deelder, A M, Yazdanbakhsh, M

“…Cellular immune responses to schistosomal antigens were examined in 110 Schistosoma haematobium-infected individuals before and 5 weeks after treatment with…”
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Antischistosome IgG4 and IgE Responses Are Affected Differentially by Chemotherapy in Children versus Adults by Grogan, Jane L., Kremsner, Peter G., van Dam, Govert J., Metzger, Wolfram, Mordmüller, Benjamin, Deelder, André M., Yazdanbakhsh, Maria

“…Specific IgG4 and IgE responses and polyclonal cytokine profiles were studied in 110 Schistosoma haematobium-infected persons before and 5 weeks after…”
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Effect of localized cytokine dysregulation: Accelerated rejection of IL-2-expressing skin grafts by Blackburn, Cc, Grogan, Jl, Augustine, Cl, Miller, Jfap, Varigos, G, Morahan, G

“…Abstract only…”
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Chronic Schistosomiasis: Dendritic Cells Generated from Patients Can Overcome Antigen-Specific T Cell Hyporesponsiveness by van den Biggelaar, Anita H. J., Grogan, Jane L., Filié, Yvonne, Jordens, Reina, Kremsner, Peter G., Koning, Frits, Yazdanbakhsh, Maria

“…Chronic infection with helminths is associated with down-regulated antigen-specific T cell responses. In order to determine whether schistosome-specific T…”
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Anti-Schistosome IgG4 and IgE at 2 Years after Chemotherapy: Infected versus Uninfected Individuals by Grogan, Jane L., Kremsner, Peter G., Dam, Govert J. van, Deelder, André M., Yazdanbakhsh, Maria

“…Specific IgG4 and IgE responses to adult worm antigen (AWA) and soluble egg antigen (SEA) were examined in 37 subjects from an area in which schistosomiasis is…”
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Diesel particulate matter exposure to railroad train crews by Liukonen, Larry R, Grogan, John L, Myers, Warren

“…Exposure assessments were conducted aboard diesel locomotives. Results were evaluated to determine variables that affect exposure to DPM (diesel particulate…”
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Effect of localized cytokine dysregulation: Accelerated rejection of IL-2-expressing skin grafts by Blackburn, CC, Grogan, JL, Augustine, CL, Miller, JFAP, Varigos, G, Morahan, G

“…Transgenic mice were created in which a sheep keratin promoter directed the expression of IL‐2 into the dermis. These KIL‐2 transgenic mice were used to…”
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