Search Results - "Groffen, J."

Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons by Bourgeois-Jaarsma, Quentin, Miaja Hernandez, Pablo, Groffen, Alexander J.

“…Presynaptic neurotransmitter release is strictly regulated by SNARE proteins, Ca2+ and a number of Ca2+ sensors including synaptotagmins (Syts) and Double C2…”
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Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes by Meijer, Marieke, Öttl, Miriam, Yang, Jie, Subkhangulova, Aygul, Kumar, Avinash, Feng, Zicheng, van Voorst, Torben W., Groffen, Alexander J., van Weering, Jan R. T., Zhang, Yongli, Verhage, Matthijs

“…Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against…”
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Doc2b Is a High-Affinity Ca²⁺ Sensor for Spontaneous Neurotransmitter Release by Groffen, Alexander J, Martens, Sascha, Arazola, Rocío Díez, Cornelisse, L. Niels, Lozovaya, Natalia, de Jong, Arthur P.H, Goriounova, Natalia A, Habets, Ron L.P, Takai, Yoshimi, Borst, J. Gerard, Brose, Nils, McMahon, Harvey T, Verhage, Matthijs

“…Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action…”
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Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs by Houy, Sébastien, Groffen, Alexander J, Ziomkiewicz, Iwona, Verhage, Matthijs, Pinheiro, Paulo S, Sørensen, Jakob Balslev

“…Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca and SNAREs…”
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DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake by Li, Jia, Cantley, James, Burchfield, James G., Meoli, Christopher C., Stöckli, Jacqueline, Whitworth, P. Tess, Pant, Himani, Chaudhuri, Rima, Groffen, Alexander J. A., Verhage, Matthijs, James, David E.

“…Aims/hypothesis Glucose-stimulated insulin secretion (GSIS) and insulin-stimulated glucose uptake are processes that rely on regulated intracellular vesicle…”
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Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics by Deurloo, M H S, Eide, S, Turlova, E, Li, Q, Spijker, S, Sun, H-S, Groffen, A J A, Feng, Z-P

“…Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation…”
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Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist by Parameswaran, R, Yu, M, Lim, M, Groffen, J, Heisterkamp, N

“…The bone marrow (BM) stromal niche can protect acute lymphoblastic leukemia (ALL) cells against the cytotoxicity of chemotherapeutic agents and is a possible…”
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Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains by Geerts, Cornelia J, Mancini, Roberta, Chen, Ning, Koopmans, Frank T W, Li, Ka Wan, Smit, August B, van Weering, Jan R T, Verhage, Matthijs, Groffen, Alexander J A

“…The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. Tomosyn contributes to synapse function…”
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TRIM3 regulates the motility of the kinesin motor protein KIF21B by Labonté, Dorthe, Thies, Edda, Pechmann, Yvonne, Groffen, Alexander J, Verhage, Matthijs, Smit, August B, van Kesteren, Ronald E, Kneussel, Matthias

“…Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is…”
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Identification of a Dutch founder mutation in MUSK causing fetal akinesia deformation sequence by Tan-Sindhunata, M Brigita, Mathijssen, Inge B, Smit, Margriet, Baas, Frank, de Vries, Johanna I, van der Voorn, J Patrick, Kluijt, Irma, Hagen, Marleen A, Blom, Eveline W, Sistermans, Erik, Meijers-Heijboer, Hanne, Waisfisz, Quinten, Weiss, Marjan M, Groffen, Alexander J

“…Fetal akinesia deformation sequence (FADS) refers to a clinically and genetically heterogeneous group of disorders with congenital malformations related to…”
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Galectin-3 in pre-B acute lymphoblastic leukemia by Fei, F, Abdel-Azim, H, Lim, M, Arutyunyan, A, von Itzstein, M, Groffen, J, Heisterkamp, N

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Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity by RAMALINGAM, Latha, OH, Eunjin, YODER, Stephanie M, BROZINICK, Joseph T, KALWAT, Michael A, GROFFEN, Alexander J, VERHAGE, Matthijs, THURMOND, Debbie C

“…Exocytosis of intracellular vesicles, such as insulin granules, is carried out by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)…”
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Development of resistance to dasatinib in Bcr Abl-positive acute lymphoblastic leukemia by Fei, F, Stoddart, S, Müschen, M, Kim, Y-m, Groffen, J, Heisterkamp, N

“…Dasatinib is a potent dual Abl/Src inhibitor approved for treatment of Philadelphia chromosome-positive (Ph-positive) leukemias. At a once-daily dose and a…”
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Genetic and phenotypic heterogeneity in sporadic and familial forms of paroxysmal dyskinesia by Groffen, Alexander J. A., Klapwijk, Thom, van Rootselaar, Anne-Fleur, Groen, Justus L., Tijssen, Marina A. J.

“…Paroxysmal dyskinesia (PxD) is a group of movement disorders characterized by recurrent episodes of involuntary movements. Familial paroxysmal kinesigenic…”
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Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells by Fei, F, Lim, M, George, A A, Kirzner, J, Lee, D, Seeger, R, Groffen, J, Abdel-Azim, H, Heisterkamp, N

“…Precursor B-lineage acute lymphoblastic leukemia (pre-B ALL) affects hematopoietic development and therefore is associated with immune deficiencies that can be…”
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Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates by Geerts, Cornelia J., Plomp, Jaap J., Koopmans, Bastijn, Loos, Maarten, van der Pijl, Elizabeth M., van der Valk, Martin A., Verhage, Matthijs, Groffen, Alexander J. A.

“…Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in…”
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Tomosyn interacts with the SUMO E3 ligase PIASγ by Geerts, Cornelia J, Jacobsen, Linda, van de Bospoort, Rhea, Verhage, Matthijs, Groffen, Alexander J A

“…Protein modification by Small Ubiquitin-like MOdifier (SUMO) entities is involved in a number of neuronal functions, including synaptogenesis and synaptic…”
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Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons by Subkhangulova, Aygul, Gonzalez-Lozano, Miguel A, Groffen, Alexander JA, van Weering, Jan RT, Smit, August B, Toonen, Ruud F, Verhage, Matthijs

“…Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the…”
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Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality by Dudok, Jacobus J, Groffen, Alexander J A, Toonen, Ruud F T, Verhage, Matthijs

“…The serotonin (5-HT) system densely innervates many brain areas and is important for proper brain development. To specifically ablate the 5-HT system we…”
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DOC2B Acts as a Calcium Switch and Enhances Vesicle Fusion by Friedrich, Reut, Groffen, Alexander J, Connell, Emma, van Weering, Jan R. T, Gutman, Orit, Henis, Yoav I, Davletov, Bazbek, Ashery, Uri

“…Calcium-dependent exocytosis is regulated by a vast number of proteins. DOC2B is a synaptic protein that translocates to the plasma membrane (PM) after small…”
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