Search Results - "Groenke, Nicole"

Mechanism of Virus Attenuation by Codon Pair Deoptimization by Groenke, Nicole, Trimpert, Jakob, Merz, Sophie, Conradie, Andelé M., Wyler, Emanuel, Zhang, Hongwei, Hazapis, Orsalia-Georgia, Rausch, Sebastian, Landthaler, Markus, Osterrieder, Nikolaus, Kunec, Dusan

“…Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that leads to attenuation is unknown. The strategy involves synthetic…”
Get full text

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America by Trimpert, Jakob, Groenke, Nicole, Jenckel, Maria, He, Shulin, Kunec, Dusan, Szpara, Moriah L., Spatz, Stephen J., Osterrieder, Nikolaus, McMahon, Dino P.

“…Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of…”
Get full text

Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear by Dayaram, Anisha, Tsangaras, Kyriakos, Pavulraj, Selvaraj, Azab, Walid, Groenke, Nicole, Wibbelt, Gudrun, Sicks, Florian, Osterrieder, Nikolaus, Greenwood, Alex D

“…Polar bears in captivity can be exposed to opportunistic pathogens not present in their natural environments. A 4-month-old polar bear ( ) living in an…”
Get full text

Overexpression of cellular telomerase RNA enhances virus-induced cancer formation by Kheimar, Ahmed, Trimpert, Jakob, Groenke, Nicole, Kaufer, Benedikt B.

“…The telomerase RNA subunit (TR) is overexpressed in many tumors; however, the contribution of TR in cancer formation remains elusive. The most frequent…”
Get full text

Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content by Wiglenda, Thomas, Groenke, Nicole, Hoffmann, Waldemar, Manz, Christian, Diez, Lisa, Buntru, Alexander, Brusendorf, Lydia, Neuendorf, Nancy, Schnoegl, Sigrid, Haenig, Christian, Schmieder, Peter, Pagel, Kevin, Wanker, Erich E.

“…The self-assembly of the 42-residue amyloid-β peptide, Aβ42, into fibrillar aggregates is associated with neuronal dysfunction and toxicity in Alzheimer’s…”
Get full text

A proofreading-impaired herpesvirus generates populations with quasispecies-like structure by Trimpert, Jakob, Groenke, Nicole, Kunec, Dusan, Eschke, Kathrin, He, Shulin, McMahon, Dino P., Osterrieder, Nikolaus

“…RNA virus populations are composed of highly diverse individuals that form a cloud of related sequences commonly referred to as a ‘quasispecies’ 1 – 3 . This…”
Get full text

DEEPGENTM—A Novel Variant Calling Assay for Low Frequency Variants by Hermann, Bernd Timo, Pfeil, Sebastian, Groenke, Nicole, Schaible, Samuel, Kunze, Robert, Ris, Frédéric, Hagen, Monika Elisabeth, Bhakdi, Johannes

“…Detection of genetic variants in clinically relevant genomic hot-spot regions has become a promising application of next-generation sequencing technology in…”
Get full text

DEEPGEN TM -A Novel Variant Calling Assay for Low Frequency Variants by Hermann, Bernd Timo, Pfeil, Sebastian, Groenke, Nicole, Schaible, Samuel, Kunze, Robert, Ris, Frédéric, Hagen, Monika Elisabeth, Bhakdi, Johannes

“…Detection of genetic variants in clinically relevant genomic hot-spot regions has become a promising application of next-generation sequencing technology in…”
Get full text

Author Correction: A proofreading-impaired herpesvirus generates populations with quasispecies-like structure by Trimpert, Jakob, Groenke, Nicole, Kunec, Dusan, Eschke, Kathrin, He, Shulin, McMahon, Dino P., Osterrieder, Nikolaus

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text