Search Results - "Groenen, Patricia Jta"
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Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases
Published in Diagnostic pathology (01-07-2014)“…Epithelioid hemangioendothelioma is a malignant, often indolent vascular tumor which occurs at various anatomic sites. Based on a reciprocal translocation t…”
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Solitary fibrous tumor - clinicopathologic, immunohistochemical and molecular analysis of 28 cases
Published in Diagnostic pathology (29-11-2014)“…Solitary fibrous tumor is a mesenchymal tumor of fibroblastic type, which can affect any region of the body. Recently, a recurrent gene fusion NAB2-STAT6 has…”
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Diagnostic and prognostic molecular pathology of lymphoid malignancies
Published in Virchows Archiv : an international journal of pathology (01-02-2024)“…With the explosion in knowledge about the molecular landscape of lymphoid malignancies and the increasing availability of high throughput techniques, molecular…”
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High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges
Published in The Journal of immunology (1950) (15-05-2017)“…Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-throughput way have their limitations in terms of resolution, coverage,…”
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Appraisal of the PathoDiscovery: an interactive web‐based educational tool for teaching pathophysiology and histopathology
Published in APMIS : acta pathologica, microbiologica et immunologica Scandinavica (01-09-2023)“…Virtual pathology education has shown to enhance the students' learning experience. At the Radboud University, an E‐learning platform—called the…”
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EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing - a structured approach with the DEPART algorithm
Published in The Journal of molecular diagnostics : JMD (01-10-2023)“…Next generation sequencing (NGS)-based clonality analysis allows in-depth assessment of the clonal composition of a sample with a high sensitivity for…”
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Primary Melanocytic Tumors of the Central Nervous System: a Review with Focus on Molecular Aspects
Published in Brain pathology (Zurich, Switzerland) (01-03-2015)“…Primary melanocytic tumors of the central nervous system (CNS) represent a spectrum of rare tumors. They can be benign or malignant and occur in adults as well…”
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T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
Published in Cancer research (Chicago, Ill.) (15-06-2016)“…Tumor-infiltrating lymphocytes appear to be a predictor of survival in many cancers, including cutaneous melanoma. We applied automated multispectral imaging…”
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Soft tissue angiofibroma: Clinicopathologic, immunohistochemical and molecular analysis of 14 cases
Published in Genes chromosomes & cancer (01-10-2017)“…Soft tissue angiofibroma is rare and has characteristic histomorphological and genetic features. For diagnostic purposes, there are no specific antibodies…”
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Next generation sequencing of synovial sarcomas
Published in Journal of clinical oncology (20-05-2015)“…Abstract only…”
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Preparing pathology for personalized medicine: possibilities for improvement of the pre-analytical phase
Published in Histopathology (01-07-2011)“…Groenen P J T A, Blokx W A M, Diepenbroek C, Burgers L, Visinoni F, Wesseling P & van Krieken J H J M (2011) Histopathology59, 1–7 Preparing pathology for…”
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Next generation diagnostic molecular pathology: Critical appraisal of quality assurance in Europe
Published in Molecular oncology (01-06-2014)“…Tumor evaluation in pathology is more and more based on a combination of traditional histopathology and molecular analysis. Due to the rapid development of new…”
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Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis
Published in Acta neuropathologica (01-12-2010)“…The histological differential diagnosis between melanotic schwannoma, primary leptomeningeal melanocytic lesions and cellular blue nevus can be challenging…”
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Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor
Published in Acta neuropathologica communications (08-04-2014)“…Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple congenital melanocytic nevi (CMN) of the…”
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Whole-genome copy-number analysis identifies new leads for chromosomal aberrations involved in the oncogenesis and metastastic behavior of uveal melanomas
Published in Melanoma research (01-06-2015)“…To further elucidate the genetic underpinnings of uveal melanoma (UM) and identify new markers that correlate with disease outcome, archival formalin-fixed,…”
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Successive Development of T-Cell Acute Lymphoblastic Leukemia, Non-Langerhans-Cell Histiocytose and Histiocytic Sarcoma with a Common Origin: Evidence for Common Oncogenetic Transformation Before Full Lineage Commitment
Published in Blood (18-11-2011)“…Abstract 3470 Hematopoiesis is traditionally seen as the unidirectional maturation of stem cells into lineage committed cells. Recent data are suggestive for…”
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Identification of prognostic relevant chromosomal abnormalities in chronic lymphocytic leukemia using microarray-based genomic profiling
Published in Molecular cytogenetics (09-01-2014)“…Characteristic genomic abnormalities in patients with B cell chronic lymphocytic leukemia (CLL) have been shown to provide important prognostic information…”
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Pitfalls in TCR gene clonality testing: teaching cases
Published in Journal of hematopathology (01-09-2008)“…Clonality testing in T-lymphoproliferations has technically become relatively easy to perform in routine laboratories using standardized multiplex polymerase…”
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Integrated genomic and expression profiling in mantle cell lymphoma: identification of gene‐dosage regulated candidate genes
Published in British journal of haematology (01-10-2008)“…Summary Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation and several other cytogenetic aberrations, including heterozygous…”
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Microarray-based genomic profiling and in situ hybridization on fibrotic bone marrow biopsies for the identification of numerical chromosomal abnormalities in myelodysplastic syndrome
Published in Molecular cytogenetics (28-05-2015)“…Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological malignancies. In MDS patients with a fibrotic bone marrow the aspiration of…”
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