Association of Postprandial Serum Triglyceride Concentration and Serum Canine Pancreatic Lipase Immunoreactivity in Overweight and Obese Dogs

Association of Postprandial Serum Triglyceride Concentration and Serum Canine Pancreatic Lipase Immunoreactivity in Overweight and Obese Dogs

Background Hypertriglyceridemia has been proposed to contribute to the risk of developing pancreatitis in dogs. Objectives To determine associations between postprandial serum triglyceride concentrations and canine pancreatic lipase immunoreactivity (cPLI) concentrations or pancreatic disease. Anima...

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Bibliographic Details
Published in:Journal of veterinary internal medicine Vol. 26; no. 1; pp. 46 - 53
Main Authors: Verkest, K.R., Fleeman, L.M., Morton, J.M., Groen, S.J., Suchodolski, J.S., Steiner, J.M., Rand, J.S.
Format: Journal Article
Language:English
Published: United States 01-01-2012
Subjects:
Animals
Cross-Sectional Studies
Dog Diseases - blood
Dog Diseases - enzymology
Dogs
Follow-Up Studies
Hypertriglyceridemia
Hypertriglyceridemia - blood
Hypertriglyceridemia - enzymology
Hypertriglyceridemia - veterinary
Lipase - blood
Lipid
Logistic Models
Obesity - enzymology
Obesity - metabolism
Obesity - veterinary
Pancreatitis
Pancreatitis - blood
Pancreatitis - enzymology
Pancreatitis - veterinary
Postprandial Period
Prospective Studies
Triglycerides - blood
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Summary:Background Hypertriglyceridemia has been proposed to contribute to the risk of developing pancreatitis in dogs. Objectives To determine associations between postprandial serum triglyceride concentrations and canine pancreatic lipase immunoreactivity (cPLI) concentrations or pancreatic disease. Animals Thirty‐five client‐owned overweight (n = 25) or obese (n = 10) dogs weighing >10 kg. Methods Healthy dogs were prospectively recruited for a cross‐sectional study. Serum triglyceride concentrations were measured before and hourly for 12 hours after a meal. Fasting cPLI and canine trypsin‐like immunoreactivity (cTLI) concentrations were assayed. Cut‐off values for hypertriglyceridemia were set a priori for fasting (≥88, ≥177, ≥354, ≥885 mg/dL) and peak postprandial (≥133, ≥442, ≥885 mg/dL) triglyceride concentrations. The association between hypertriglyceridemia and high cPLI concentrations was assessed by exact logistic regression. Follow‐up was performed 4 years later to determine the incidence of pancreatic disease. Results Eight dogs had peak postprandial triglycerides >442 mg/dL and 3 dogs had fasting serum cPLI concentrations ≥400 μg/L. Odds of high cPLI concentrations were 16.7 times higher in dogs with peak postprandial triglyceride concentrations ≥442 mg/dL relative to other dogs (P < .001). Fasting triglyceride concentration was not significantly associated with cPLI concentrations. None of the dogs with high triglyceride concentrations and one of the dogs with low fasting and peak postprandial triglyceride concentrations developed clinically important pancreatic disease. Conclusions and Clinical Importance Overweight and obese dogs with peak serum postprandial triglyceride concentrations ≥442 mg/dL after a standard meal are more likely to have serum cPLI concentrations ≥400 μg/L, but did not develop clinically important pancreatic disease.
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ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2011.00844.x