Search Results - "Groen, Albert K."

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism by den Besten, Gijs, van Eunen, Karen, Groen, Albert K., Venema, Koen, Reijngoud, Dirk-Jan, Bakker, Barbara M.

“…Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the anaerobic intestinal microbiota, have been shown to exert multiple…”
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Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction by Bouter, Kristien E, van Raalte, Daniël H, Groen, Albert K, Nieuwdorp, Max

“…The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. As such, the…”
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Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells by Thedieck, Kathrin, Holzwarth, Birgit, Prentzell, Mirja Tamara, Boehlke, Christopher, Kläsener, Kathrin, Ruf, Stefanie, Sonntag, Annika Gwendolin, Maerz, Lars, Grellscheid, Sushma-Nagaraja, Kremmer, Elisabeth, Nitschke, Roland, Kuehn, E. Wolfgang, Jonker, Johan W., Groen, Albert K., Reth, Michael, Hall, Michael N., Baumeister, Ralf

“…Mammalian target of rapamycin complex 1 (mTORC1) controls growth and survival in response to metabolic cues. Oxidative stress affects mTORC1 via inhibitory and…”
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VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications by Robciuc, Marius R., Kivelä, Riikka, Williams, Ian M., de Boer, Jan Freark, van Dijk, Theo H., Elamaa, Harri, Tigistu-Sahle, Feven, Molotkov, Dmitry, Leppänen, Veli-Matti, Käkelä, Reijo, Eklund, Lauri, Wasserman, David H., Groen, Albert K., Alitalo, Kari

“…Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, we report the…”
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Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance by Lee, Sunjae, Zhang, Cheng, Kilicarslan, Murat, Piening, Brian D., Bjornson, Elias, Hallström, Björn M., Groen, Albert K., Ferrannini, Ele, Laakso, Markku, Snyder, Michael, Blüher, Matthias, Uhlen, Mathias, Nielsen, Jens, Smith, Ulf, Serlie, Mireille J., Boren, Jan, Mardinoglu, Adil

“…To investigate the biological processes that are altered in obese subjects, we generated cell-specific integrated networks (INs) by merging genome-scale…”
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Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation by Schnitzler, Johan G., Hoogeveen, Renate M., Ali, Lubna, Prange, Koen H.M., Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C., Versloot, Miranda, Borrelli, Matthew J., Yeang, Calvin, De Kleijn, Dominique P.V., Houtkooper, Riekelt H., Koschinsky, Marlys L., de Winther, Menno P.J., Groen, Albert K., Witztum, Joseph L., Tsimikas, Sotirios, Stroes, Erik S.G., Kroon, Jeffrey

“…Patients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission…”
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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy by van Stee, Mariël F, de Graaf, Albert A, Groen, Albert K

“…Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug…”
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Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial by Reijnders, Dorien, Goossens, Gijs H., Hermes, Gerben D.A., Neis, Evelien P.J.G., van der Beek, Christina M., Most, Jasper, Holst, Jens J., Lenaerts, Kaatje, Kootte, Ruud S., Nieuwdorp, Max, Groen, Albert K., Olde Damink, Steven W.M., Boekschoten, Mark V., Smidt, Hauke, Zoetendal, Erwin G., Dejong, Cornelis H.C., Blaak, Ellen E.

“…The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota…”
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Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion by Jakulj, Lily, van Dijk, Theo H., de Boer, Jan Freark, Kootte, Ruud S., Schonewille, Marleen, Paalvast, Yared, Boer, Theo, Bloks, Vincent W., Boverhof, Renze, Nieuwdorp, Max, Beuers, Ulrich H.W., Stroes, Erik S.G., Groen, Albert K.

“…Except for conversion to bile salts, there is no major cholesterol degradation pathway in mammals. Efficient excretion from the body is therefore a crucial…”
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Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction by van Zutphen, Tim, Ciapaite, Jolita, Bloks, Vincent W, Ackereley, Cameron, Gerding, Albert, Jurdzinski, Angelika, de Moraes, Roberta Allgayer, Zhang, Ling, Wolters, Justina C, Bischoff, Rainer, Wanders, Ronald J, Houten, Sander M, Bronte-Tinkew, Dana, Shatseva, Tatiana, Lewis, Gary F, Groen, Albert K, Reijngoud, Dirk-Jan, Bakker, Barbara M, Jonker, Johan W, Kim, Peter K, Bandsma, Robert H.J

“…Graphical abstract…”
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Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences by Hijmans, Brenda S., Grefhorst, Aldo, Oosterveer, Maaike H., Groen, Albert K.

“…The liver is generally considered as a relatively homogeneous organ containing four different cell types. It is however well-known that the liver is not…”
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Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice by Schonewille, Marleen, Freark de Boer, Jan, Mele, Laura, Wolters, Henk, Bloks, Vincent W., Wolters, Justina C., Kuivenhoven, Jan A., Tietge, Uwe J.F., Brufau, Gemma, Groen, Albert K.

“…Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but…”
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Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus by van Olden, Casper, Msc, Groen, Albert K., PhD, Nieuwdorp, Max, MD, PhD

“…Abstract Purpose The contribution of intestinal bacterial strains (gut microbiota) in human metabolism and obesity is being increasingly recognized. The goal…”
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CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL by Bartuzi, Paulina, Billadeau, Daniel D., Favier, Robert, Rong, Shunxing, Dekker, Daphne, Fedoseienko, Alina, Fieten, Hille, Wijers, Melinde, Levels, Johannes H., Huijkman, Nicolette, Kloosterhuis, Niels, van der Molen, Henk, Brufau, Gemma, Groen, Albert K., Elliott, Alison M., Kuivenhoven, Jan Albert, Plecko, Barbara, Grangl, Gernot, McGaughran, Julie, Horton, Jay D., Burstein, Ezra, Hofker, Marten H., van de Sluis, Bart

“…The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show…”
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Transintestinal cholesterol excretion in humans by Reeskamp, Laurens F, Meessen, Emma C E, Groen, Albert K

“…To discuss recent insights into the measurement and cellular basis of transintestinal cholesterol excretion (TICE) in humans and to explore TICE as a…”
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Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype by Vaz, Frédéric M., Paulusma, Coen C., Huidekoper, Hidde, de Ru, Minke, Lim, Cynthia, Koster, Janet, Ho‐Mok, Kam, Bootsma, Albert H., Groen, Albert K., Schaap, Frank G., Oude Elferink, Ronald P. J., Waterham, Hans R., Wanders, Ronald J.A.

“…The enterohepatic circulation of bile salts is an important physiological route to recycle bile salts and ensure intestinal absorption of dietary lipids. The…”
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Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content by Chen, Lianmin, van den Munckhof, Inge C.L., Schraa, Kiki, ter Horst, Rob, Koehorst, Martijn, van Faassen, Martijn, van der Ley, Claude, Doestzada, Marwah, Zhernakova, Daria V., Kurilshikov, Alexander, Bloks, Vincent W., Groen, Albert K., Riksen, Niels P., Rutten, Joost H.W., Joosten, Leo A.B., Wijmenga, Cisca, Zhernakova, Alexandra, Netea, Mihai G., Fu, Jingyuan, Kuipers, Folkert

“…Bile acids (BAs) are implicated in the etiology of obesity-related conditions such as non-alcoholic fatty liver disease. Differently structured BA species…”
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Human microbiome as therapeutic intervention target to reduce cardiovascular disease risk by Koopen, Annefleur M., Groen, Albert K., Nieuwdorp, Max

“…The absolute burden of cardiovascular risk remains high despite currently available preventive and therapeutic options. In search for novel therapeutic leads,…”
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An evaluation of the therapeutic potential of fecal microbiota transplantation to treat infectious and metabolic diseases by Groen, Albert K, Nieuwdorp, Max

“…Fecal microbiota transplantation (FMT) has had a long history in medicine for treating a number of human diseases. As early as during the 4 th century BC, FMT…”
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Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1 by Kaur, Achint, Patankar, Jay V, de Haan, Willeke, Ruddle, Piers, Wijesekara, Nadeeja, Groen, Albert K, Verchere, C Bruce, Singaraja, Roshni R, Hayden, Michael R

“…Besides their role in facilitating lipid absorption, bile acids are increasingly being recognized as signaling molecules that activate cell-signaling…”
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