Search Results - "Groemer, Teja W"

Identification of novel functional inhibitors of acid sphingomyelinase by Kornhuber, Johannes, Muehlbacher, Markus, Trapp, Stefan, Pechmann, Stefanie, Friedl, Astrid, Reichel, Martin, Mühle, Christiane, Terfloth, Lothar, Groemer, Teja W, Spitzer, Gudrun M, Liedl, Klaus R, Gulbins, Erich, Tripal, Philipp

“…We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named…”
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Amyloid precursor protein is trafficked and secreted via synaptic vesicles by Groemer, Teja W, Thiel, Cora S, Holt, Matthew, Riedel, Dietmar, Hua, Yunfeng, Hüve, Jana, Wilhelm, Benjamin G, Klingauf, Jürgen

“…A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal…”
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Use-Dependent Inhibition of Synaptic Transmission by the Secretion of Intravesicularly Accumulated Antipsychotic Drugs by Tischbirek, Carsten H., Wenzel, Eva M., Zheng, Fang, Huth, Tobias, Amato, Davide, Trapp, Stefan, Denker, Annette, Welzel, Oliver, Lueke, Katharina, Svetlitchny, Alexei, Rauh, Manfred, Deusser, Janina, Schwab, Annemarie, Rizzoli, Silvio O., Henkel, Andreas W., Müller, Christian P., Alzheimer, Christian, Kornhuber, Johannes, Groemer, Teja W.

“…Antipsychotic drugs are effective for the treatment of schizophrenia. However, the functional consequences and subcellular sites of their accumulation in…”
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Depression, Anxiety, Resilience and Coping Pre and Post Kidney Transplantation - Initial Findings from the Psychiatric Impairments in Kidney Transplantation (PI-KT)-Study by Müller, Helge H, Englbrecht, Matthias, Wiesener, Michael S, Titze, Stephanie, Heller, Katharina, Groemer, Teja W, Schett, Georg, Eckardt, Kai-Uwe, Kornhuber, Johannes, Maler, Juan Manuel

“…Depression/anxiety, impaired Health-Related Quality of Life (HRQoL) and coping and resilience structures, are associated with increased mortality/poor outcome…”
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Key physiological parameters dictate triggering of activity-dependent bulk endocytosis in hippocampal synapses by Wenzel, Eva M, Morton, Andrew, Ebert, Katrin, Welzel, Oliver, Kornhuber, Johannes, Cousin, Michael A, Groemer, Teja W

“…To maintain neurotransmission in central neurons, several mechanisms are employed to retrieve synaptically exocytosed membrane. The two major modes of synaptic…”
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Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system by Kornhuber, Johannes, Henkel, Andreas W., Groemer, Teja W., Städtler, Sven, Welzel, Oliver, Tripal, Philipp, Rotter, Andrea, Bleich, Stefan, Trapp, Stefan

“…Lysosomes accumulate many drugs several fold higher compared to their extracellular concentration. This mechanism is believed to be responsible for many…”
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Dynamic properties of the alkaline vesicle population at hippocampal synapses by Röther, Mareike, Brauner, Jan M, Ebert, Katrin, Welzel, Oliver, Jung, Jasmin, Bauereiss, Anna, Kornhuber, Johannes, Groemer, Teja W

“…In compensatory endocytosis, scission of vesicles from the plasma membrane to the cytoplasm is a prerequisite for intravesicular reacidification and…”
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Synapse clusters are preferentially formed by synapses with large recycling pool sizes by Welzel, Oliver, Tischbirek, Carsten H, Jung, Jasmin, Kohler, Eva M, Svetlitchny, Alexei, Henkel, Andreas W, Kornhuber, Johannes, Groemer, Teja W

“…Synapses are distributed heterogeneously in neural networks. The relationship between the spatial arrangement of synapses and an individual synapse's…”
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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies by Prots, Iryna, Grosch, Janina, Brazdis, Razvan-Marius, Simmnacher, Katrin, Veber, Vanesa, Havlicek, Steven, Hannappel, Christian, Krach, Florian, Krumbiegel, Mandy, Schütz, Oliver, Reis, André, Wrasidlo, Wolfgang, Galasko, Douglas R., Groemer, Teja W., Masliah, Eliezer, Schlötzer-Schrehardt, Ursula, Xiang, Wei, Winkler, Jürgen, Winner, Beate

“…α-Synuclein (α-Syn) aggregation, proceeding fromoligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are…”
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iPad-assisted measurements of duration estimation in psychiatric patients and healthy control subjects by Preuschoff, Irene, Müller, Helge H, Sperling, Wolfgang, Biermann, Teresa, Bergner, Matthias, Kornhuber, Johannes, Groemer, Teja W

“…Handheld devices with touchscreen controls have become widespread in the general population. In this study, we examined the duration estimates (explicit…”
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A fast and robust method for automated analysis of axonal transport by Welzel, Oliver, Knörr, Jutta, Stroebel, Armin M., Kornhuber, Johannes, Groemer, Teja W.

“…Cargo movement along axons and dendrites is indispensable for the survival and maintenance of neuronal networks. Key parameters of this transport such as…”
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Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool by Klingauf, Jurgen, Groemer, Teja W

“…Recently, it has been claimed that vesicles recycling spontaneously and during activity belong to different pools. Here we simultaneously measured, using…”
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Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs by Gulbins, Erich, Palmada, Monica, Reichel, Martin, Lüth, Anja, Böhmer, Christoph, Amato, Davide, Müller, Christian P, Tischbirek, Carsten H, Groemer, Teja W, Tabatabai, Ghazaleh, Becker, Katrin A, Tripal, Philipp, Staedtler, Sven, Ackermann, Teresa F, van Brederode, Johannes, Alzheimer, Christian, Weller, Michael, Lang, Undine E, Kleuser, Burkhard, Grassmé, Heike, Kornhuber, Johannes

“…Depression is a debilitating condition for which new treatments are sorely needed. Now, Erich Gulbins and his colleagues report that reducing ceramide levels…”
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Aptamers as potential tools for super-resolution microscopy by Opazo, Felipe, Levy, Matthew, Byrom, Michelle, Schäfer, Christina, Geisler, Claudia, Groemer, Teja W, Ellington, Andrew D, Rizzoli, Silvio O

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Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications by Kornhuber, Johannes, Tripal, Philipp, Reichel, Martin, Mühle, Christiane, Rhein, Cosima, Muehlbacher, Markus, Groemer, Teja W., Gulbins, Erich

“…Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further…”
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Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia by Pérez-Brangulí, Francesc, Mishra, Himanshu K, Prots, Iryna, Havlicek, Steven, Kohl, Zacharias, Saul, Domenica, Rummel, Christine, Dorca-Arevalo, Jonatan, Regensburger, Martin, Graef, Daniela, Sock, Elisabeth, Blasi, Juan, Groemer, Teja W, Schlötzer-Schrehardt, Ursula, Winkler, Jürgen, Winner, Beate

“…Hereditary spastic paraplegias are a group of inherited motor neuron diseases characterized by progressive paraparesis and spasticity. Mutations in the spastic…”
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Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients’ neurons by Havlicek, Steven, Kohl, Zacharias, Mishra, Himanshu K., Prots, Iryna, Eberhardt, Esther, Denguir, Naime, Wend, Holger, Plötz, Sonja, Boyer, Leah, Marchetto, Maria C.N., Aigner, Stefan, Sticht, Heinrich, Groemer, Teja W., Hehr, Ute, Lampert, Angelika, Schlötzer-Schrehardt, Ursula, Winkler, Jürgen, Gage, Fred H., Winner, Beate

“…The hereditary spastic paraplegias (HSPs) are a heterogeneous group of motorneuron diseases characterized by progressive spasticity and paresis of the lower…”
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The same synaptic vesicles drive active and spontaneous release by Rizzoli, Silvio O, Wilhelm, Benjamin G, Groemer, Teja W

“…Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both…”
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Functional Viability: Measurement of Synaptic Vesicle Pool Sizes by Wrosch, Jana K, Groemer, Teja W

“…Neurons and their function of conveying information across a chemical synapse are highly regulated systems. Impacts on their functional viability can occur…”
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BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs ) by Agsten, Marianne, Hessler, Sabine, Lehnert, Sandra, Volk, Tilmann, Rittger, Andrea, Hartmann, Stephanie, Raab, Christian, Kim, Doo Yeon, Groemer, Teja W, Schwake, Michael, Alzheimer, Christian, Huth, Tobias

“…Abstract KCNQ1 (Kv7.1) proteins form a homotetrameric channel, which produces a voltage-dependent K+ current. Co-assembly of KCNQ1 with the auxiliary β-subunit…”
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